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CD44: A multifunctional mediator of cancer progression

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to...

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Main Authors: Malak Hassn, Mesrati, Syafruddin, Saiful Effendi, Mohtar, M. Aiman, Syahir, Amir
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/96309/
https://www.mdpi.com/2218-273X/11/12/1850
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spelling my.upm.eprints.963092023-02-13T02:35:33Z http://psasir.upm.edu.my/id/eprint/96309/ CD44: A multifunctional mediator of cancer progression Malak Hassn, Mesrati Syafruddin, Saiful Effendi Mohtar, M. Aiman Syahir, Amir CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and radiotherapy. The CD44 gene regularly undergoes alternative splicing, resulting in the standard (CD44s) and variant (CD44v) isoforms. The interaction of such isoforms with ligands, particularly hyaluronic acid (HA), osteopontin (OPN) and matrix metalloproteinases (MMPs), drive numerous cancer-associated signalling. However, there are contradictory results regarding whether high or low CD44 expression is associated with worsening clinicopathological features, such as a higher tumour histological grade, advanced tumour stage and poorer survival rates. Nonetheless, high CD44 expression significantly contributes to enhanced tumourigenic mechanisms, such as cell proliferation, metastasis, invasion, migration and stemness; hence, CD44 is an important clinical target. This review summarises current research regarding the different CD44 isoform structures and their roles and functions in supporting tumourigenesis and discusses CD44 expression regulation, CD44-signalling pathways and interactions involved in cancer development. The clinical significance and prognostic value of CD44 and the potential of CD44 as a therapeutic target in cancer are also addressed. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Malak Hassn, Mesrati and Syafruddin, Saiful Effendi and Mohtar, M. Aiman and Syahir, Amir (2021) CD44: A multifunctional mediator of cancer progression. Biomolecules, 11 (12). art. no. 1850. pp. 1-32. ISSN 2218-273X https://www.mdpi.com/2218-273X/11/12/1850 10.3390/biom11121850
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and radiotherapy. The CD44 gene regularly undergoes alternative splicing, resulting in the standard (CD44s) and variant (CD44v) isoforms. The interaction of such isoforms with ligands, particularly hyaluronic acid (HA), osteopontin (OPN) and matrix metalloproteinases (MMPs), drive numerous cancer-associated signalling. However, there are contradictory results regarding whether high or low CD44 expression is associated with worsening clinicopathological features, such as a higher tumour histological grade, advanced tumour stage and poorer survival rates. Nonetheless, high CD44 expression significantly contributes to enhanced tumourigenic mechanisms, such as cell proliferation, metastasis, invasion, migration and stemness; hence, CD44 is an important clinical target. This review summarises current research regarding the different CD44 isoform structures and their roles and functions in supporting tumourigenesis and discusses CD44 expression regulation, CD44-signalling pathways and interactions involved in cancer development. The clinical significance and prognostic value of CD44 and the potential of CD44 as a therapeutic target in cancer are also addressed.
format Article
author Malak Hassn, Mesrati
Syafruddin, Saiful Effendi
Mohtar, M. Aiman
Syahir, Amir
spellingShingle Malak Hassn, Mesrati
Syafruddin, Saiful Effendi
Mohtar, M. Aiman
Syahir, Amir
CD44: A multifunctional mediator of cancer progression
author_facet Malak Hassn, Mesrati
Syafruddin, Saiful Effendi
Mohtar, M. Aiman
Syahir, Amir
author_sort Malak Hassn, Mesrati
title CD44: A multifunctional mediator of cancer progression
title_short CD44: A multifunctional mediator of cancer progression
title_full CD44: A multifunctional mediator of cancer progression
title_fullStr CD44: A multifunctional mediator of cancer progression
title_full_unstemmed CD44: A multifunctional mediator of cancer progression
title_sort cd44: a multifunctional mediator of cancer progression
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/96309/
https://www.mdpi.com/2218-273X/11/12/1850
_version_ 1758579860291190784
score 13.211869

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