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An overview of breast cancer: classification and related signaling pathways

The burden of cancer continues to grow in developed and developing countries, with about 70% of all cancer mortality in low- and middle-income countries. Among different cancer types, breast cancer is recognized as one of the five most common causes of death in cancer in women worldwide, right after...

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Main Authors: Chan, Pit Foong, Abd Hamid @ Abdul Razak, Roslida
Format: Article
Published: HH Publisher 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95879/
https://journals.hh-publisher.com/index.php/pmmb/article/view/458
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spelling my.upm.eprints.958792023-03-23T03:33:49Z http://psasir.upm.edu.my/id/eprint/95879/ An overview of breast cancer: classification and related signaling pathways Chan, Pit Foong Abd Hamid @ Abdul Razak, Roslida The burden of cancer continues to grow in developed and developing countries, with about 70% of all cancer mortality in low- and middle-income countries. Among different cancer types, breast cancer is recognized as one of the five most common causes of death in cancer in women worldwide, right after lung cancer. Histological classification divides breast tumors into different categories based on their behavior and clinical outcome. However, the histological classification system has some limitations, thus molecular subtype classification has been studied extensively to improve the classification system for breast cancer. Like any other cancers, several signaling pathways that enhance the proliferation, survival, invasion, and metastasis capability of tumor cells have been observed in breast cancer. These crucial signaling pathways contributing to the etiology of breast cancer include breast tumor kinase (BRK) pathway, Notch signaling, Nuclear Factor-kappaB (NF-κB) pathway, and human epidermal growth factor receptor (HER) pathway. In the present review article, we summarize our current understanding of breast cancer and its signaling pathways, which serve as basic information on tumor formation, maintenance, and expansion that could help form better breast cancer management in patients. HH Publisher 2021 Article PeerReviewed Chan, Pit Foong and Abd Hamid @ Abdul Razak, Roslida (2021) An overview of breast cancer: classification and related signaling pathways. Progress in Microbes and Molecular Biology, 4 (1). pp. 1-14. ISSN 2637-1049 https://journals.hh-publisher.com/index.php/pmmb/article/view/458 10.36877/pmmb.a0000194
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The burden of cancer continues to grow in developed and developing countries, with about 70% of all cancer mortality in low- and middle-income countries. Among different cancer types, breast cancer is recognized as one of the five most common causes of death in cancer in women worldwide, right after lung cancer. Histological classification divides breast tumors into different categories based on their behavior and clinical outcome. However, the histological classification system has some limitations, thus molecular subtype classification has been studied extensively to improve the classification system for breast cancer. Like any other cancers, several signaling pathways that enhance the proliferation, survival, invasion, and metastasis capability of tumor cells have been observed in breast cancer. These crucial signaling pathways contributing to the etiology of breast cancer include breast tumor kinase (BRK) pathway, Notch signaling, Nuclear Factor-kappaB (NF-κB) pathway, and human epidermal growth factor receptor (HER) pathway. In the present review article, we summarize our current understanding of breast cancer and its signaling pathways, which serve as basic information on tumor formation, maintenance, and expansion that could help form better breast cancer management in patients.
format Article
author Chan, Pit Foong
Abd Hamid @ Abdul Razak, Roslida
spellingShingle Chan, Pit Foong
Abd Hamid @ Abdul Razak, Roslida
An overview of breast cancer: classification and related signaling pathways
author_facet Chan, Pit Foong
Abd Hamid @ Abdul Razak, Roslida
author_sort Chan, Pit Foong
title An overview of breast cancer: classification and related signaling pathways
title_short An overview of breast cancer: classification and related signaling pathways
title_full An overview of breast cancer: classification and related signaling pathways
title_fullStr An overview of breast cancer: classification and related signaling pathways
title_full_unstemmed An overview of breast cancer: classification and related signaling pathways
title_sort overview of breast cancer: classification and related signaling pathways
publisher HH Publisher
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95879/
https://journals.hh-publisher.com/index.php/pmmb/article/view/458
_version_ 1761620396075909120
score 13.211869

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