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An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies

This paper proposes a novel idea to enhance the sensitivity and selectivity of surface plasmon resonance (SPR) optical sensor for detection of dengue virus type-2 envelope proteins (DENV-2 E-proteins) using polyamidoamine (PAMAM) dendrimer biopolymer-based nanocomposite thin film. For this purpose,...

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Main Authors: Omar, Nur Alia Sheh, Yap, Wing Fen, Ramli, Irmawati, Sadrolhosseini, Amir Reza, Abdullah, Jaafar, Yusof, Nor Azah, Mustapha Kamil, Yasmin, Mahdi, Mohd Adzir
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Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95871/
https://www.mdpi.com/2073-4360/13/5/762
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spelling my.upm.eprints.958712023-03-22T08:10:49Z http://psasir.upm.edu.my/id/eprint/95871/ An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies Omar, Nur Alia Sheh Yap, Wing Fen Ramli, Irmawati Sadrolhosseini, Amir Reza Abdullah, Jaafar Yusof, Nor Azah Mustapha Kamil, Yasmin Mahdi, Mohd Adzir This paper proposes a novel idea to enhance the sensitivity and selectivity of surface plasmon resonance (SPR) optical sensor for detection of dengue virus type-2 envelope proteins (DENV-2 E-proteins) using polyamidoamine (PAMAM) dendrimer biopolymer-based nanocomposite thin film. For this purpose, two ranges of DENV-2 E-protein concentrations, i.e., 0.000008–0.0001 nM and 0.00008–0.005 nM were evaluated, and the lowest detectable concentration was achieved at 0.00008 nM. The incorporation of PAMAM dendrimer-based nanocomposite thin film with an SPR sensor exhibited a significant increase in sensitivity and binding affinity to a lower range DENV-2 E-protein concentrations. Moreover, the proposed sensor displayed good selectivity towards DENV-2 E-proteins and have an average recovery of 80–120%. The findings of this study demonstrated that PAMAM dendrimer-based nanocomposite thin film combined with SPR sensor is a promising diagnostic tool for sensitive and selective detection of DENV-2 E-proteins. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Omar, Nur Alia Sheh and Yap, Wing Fen and Ramli, Irmawati and Sadrolhosseini, Amir Reza and Abdullah, Jaafar and Yusof, Nor Azah and Mustapha Kamil, Yasmin and Mahdi, Mohd Adzir (2021) An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies. Polymers, 13 (5). art. no. 762. pp. 1-14. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/5/762 10.3390/polym13050762
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description This paper proposes a novel idea to enhance the sensitivity and selectivity of surface plasmon resonance (SPR) optical sensor for detection of dengue virus type-2 envelope proteins (DENV-2 E-proteins) using polyamidoamine (PAMAM) dendrimer biopolymer-based nanocomposite thin film. For this purpose, two ranges of DENV-2 E-protein concentrations, i.e., 0.000008–0.0001 nM and 0.00008–0.005 nM were evaluated, and the lowest detectable concentration was achieved at 0.00008 nM. The incorporation of PAMAM dendrimer-based nanocomposite thin film with an SPR sensor exhibited a significant increase in sensitivity and binding affinity to a lower range DENV-2 E-protein concentrations. Moreover, the proposed sensor displayed good selectivity towards DENV-2 E-proteins and have an average recovery of 80–120%. The findings of this study demonstrated that PAMAM dendrimer-based nanocomposite thin film combined with SPR sensor is a promising diagnostic tool for sensitive and selective detection of DENV-2 E-proteins.
format Article
author Omar, Nur Alia Sheh
Yap, Wing Fen
Ramli, Irmawati
Sadrolhosseini, Amir Reza
Abdullah, Jaafar
Yusof, Nor Azah
Mustapha Kamil, Yasmin
Mahdi, Mohd Adzir
spellingShingle Omar, Nur Alia Sheh
Yap, Wing Fen
Ramli, Irmawati
Sadrolhosseini, Amir Reza
Abdullah, Jaafar
Yusof, Nor Azah
Mustapha Kamil, Yasmin
Mahdi, Mohd Adzir
An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
author_facet Omar, Nur Alia Sheh
Yap, Wing Fen
Ramli, Irmawati
Sadrolhosseini, Amir Reza
Abdullah, Jaafar
Yusof, Nor Azah
Mustapha Kamil, Yasmin
Mahdi, Mohd Adzir
author_sort Omar, Nur Alia Sheh
title An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
title_short An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
title_full An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
title_fullStr An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
title_full_unstemmed An optical sensor for dengue envelope proteins using Polyamidoamine Dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
title_sort optical sensor for dengue envelope proteins using polyamidoamine dendrimer biopolymer-based nanocomposite thin film: enhanced sensitivity, selectivity, and recovery studies
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95871/
https://www.mdpi.com/2073-4360/13/5/762
_version_ 1761620395420549120
score 13.211869

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