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An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials

Cancer is one of the leading causes of death worldwide, with a mortality rate of more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance is still a major problem especially in metastatic disease. Targeted anti-cancer the...

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Main Authors: Abdullah, Nurul Akmaryanti, Md Hashim, Nur Fariesha, Ammar, Aula, Muhamad Zakuan, Noraina
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95859/
https://www.mdpi.com/1420-3049/26/4/775
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spelling my.upm.eprints.958592023-03-28T08:00:48Z http://psasir.upm.edu.my/id/eprint/95859/ An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials Abdullah, Nurul Akmaryanti Md Hashim, Nur Fariesha Ammar, Aula Muhamad Zakuan, Noraina Cancer is one of the leading causes of death worldwide, with a mortality rate of more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance is still a major problem especially in metastatic disease. Targeted anti-cancer therapy is increasingly used with conventional therapy to improve patients’ outcomes in advanced and metastatic tumors. However, due to the complexity of cancer biology and metastasis, it is urgent to develop new agents and evaluate the anti-cancer efficacy of available treatments. Many phytochemicals from medicinal plants have been reported to possess anti-cancer properties. One such compound is known as oridonin, a bioactive component of Rabdosia rubescens. Several studies have demonstrated that oridonin inhibits angiogenesis in various types of cancer, including breast, pancreatic, lung, colon and skin cancer. Oridonin’s anti-cancer effects are mediated through the modulation of several signaling pathways which include upregulation of oncogenes and pro-angiogenic growth factors. Furthermore, oridonin also inhibits cell migration, invasion and metastasis via suppressing epithelial-to-mesenchymal transition and blocking downstream signaling targets in the cancer metastasis process. This review summarizes the recent applications of oridonin as an anti-angiogenic and anti-metastatic drug both in vitro and in vivo, and its potential mechanisms of action. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Abdullah, Nurul Akmaryanti and Md Hashim, Nur Fariesha and Ammar, Aula and Muhamad Zakuan, Noraina (2021) An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials. Molecules, 26 (4). art. no. 775. pp. 1-17. ISSN 1420-3049 https://www.mdpi.com/1420-3049/26/4/775 10.3390/molecules26040775
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Cancer is one of the leading causes of death worldwide, with a mortality rate of more than 9 million deaths reported in 2018. Conventional anti-cancer therapy can greatly improve survival however treatment resistance is still a major problem especially in metastatic disease. Targeted anti-cancer therapy is increasingly used with conventional therapy to improve patients’ outcomes in advanced and metastatic tumors. However, due to the complexity of cancer biology and metastasis, it is urgent to develop new agents and evaluate the anti-cancer efficacy of available treatments. Many phytochemicals from medicinal plants have been reported to possess anti-cancer properties. One such compound is known as oridonin, a bioactive component of Rabdosia rubescens. Several studies have demonstrated that oridonin inhibits angiogenesis in various types of cancer, including breast, pancreatic, lung, colon and skin cancer. Oridonin’s anti-cancer effects are mediated through the modulation of several signaling pathways which include upregulation of oncogenes and pro-angiogenic growth factors. Furthermore, oridonin also inhibits cell migration, invasion and metastasis via suppressing epithelial-to-mesenchymal transition and blocking downstream signaling targets in the cancer metastasis process. This review summarizes the recent applications of oridonin as an anti-angiogenic and anti-metastatic drug both in vitro and in vivo, and its potential mechanisms of action.
format Article
author Abdullah, Nurul Akmaryanti
Md Hashim, Nur Fariesha
Ammar, Aula
Muhamad Zakuan, Noraina
spellingShingle Abdullah, Nurul Akmaryanti
Md Hashim, Nur Fariesha
Ammar, Aula
Muhamad Zakuan, Noraina
An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
author_facet Abdullah, Nurul Akmaryanti
Md Hashim, Nur Fariesha
Ammar, Aula
Muhamad Zakuan, Noraina
author_sort Abdullah, Nurul Akmaryanti
title An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
title_short An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
title_full An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
title_fullStr An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
title_full_unstemmed An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
title_sort insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95859/
https://www.mdpi.com/1420-3049/26/4/775
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score 13.211869

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