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A focused review of synthetic applications of Lawesson’s reagent in organic synthesis

Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exempl...

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Main Authors: Khatoon, Hena, Abdulmalek, Emilia
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95739/
https://www.mdpi.com/1420-3049/26/22/6937
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spelling my.upm.eprints.957392023-04-06T07:56:53Z http://psasir.upm.edu.my/id/eprint/95739/ A focused review of synthetic applications of Lawesson’s reagent in organic synthesis Khatoon, Hena Abdulmalek, Emilia Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson’s reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds. The ease of availability and the convenient usage of LR as a thionating agent made us compile a review on the new diverse applications on some common functional groups, such as ketones, esters, amides, alcohols, and carboxylic acids, with biological applications. Since the applications of LR are now diverse, we have also included some new classes of heterocycles such as thiazepines, phosphine sulfides, thiophenes, and organothiophosphorus compounds. Thionation of some biologically essential steroids and terpenoids has also been compiled. This review discusses the recent insights into and synthetic applications of this famous reagent from 2009 to January 2021. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Khatoon, Hena and Abdulmalek, Emilia (2021) A focused review of synthetic applications of Lawesson’s reagent in organic synthesis. Molecules, 26 (22). art. no. 6937. pp. 1-45. ISSN 1420-3049 https://www.mdpi.com/1420-3049/26/22/6937 10.3390/molecules26226937
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson’s reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds. The ease of availability and the convenient usage of LR as a thionating agent made us compile a review on the new diverse applications on some common functional groups, such as ketones, esters, amides, alcohols, and carboxylic acids, with biological applications. Since the applications of LR are now diverse, we have also included some new classes of heterocycles such as thiazepines, phosphine sulfides, thiophenes, and organothiophosphorus compounds. Thionation of some biologically essential steroids and terpenoids has also been compiled. This review discusses the recent insights into and synthetic applications of this famous reagent from 2009 to January 2021.
format Article
author Khatoon, Hena
Abdulmalek, Emilia
spellingShingle Khatoon, Hena
Abdulmalek, Emilia
A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
author_facet Khatoon, Hena
Abdulmalek, Emilia
author_sort Khatoon, Hena
title A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
title_short A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
title_full A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
title_fullStr A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
title_full_unstemmed A focused review of synthetic applications of Lawesson’s reagent in organic synthesis
title_sort focused review of synthetic applications of lawesson’s reagent in organic synthesis
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95739/
https://www.mdpi.com/1420-3049/26/22/6937
_version_ 1762839469988249600
score 13.211869

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