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The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system

Background: Cannabis and its extracts are now being explored due to their huge health benefits. Although, the effect they elicit, whether on humans or rodents, may vary based on the age of the animal/subject and or the time in which the extract is administered. However, several debates exist concern...

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Main Authors: Mahdi, Onesimus, Baharuldin, Mohamad Taufik Hidayat, M. Nor, Nurul Huda, Chiroma, Samaila Musa, Jagadeesan, Saravanan, Mohd Moklas, Mohamad Aris
Format: Article
Language:English
Published: Bentham Science Publishers 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95542/1/The%20neuroprotective%20properties%2C%20functions.pdf
http://psasir.upm.edu.my/id/eprint/95542/
https://www.eurekaselect.com/article/113707
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spelling my.upm.eprints.955422022-12-19T08:51:12Z http://psasir.upm.edu.my/id/eprint/95542/ The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system Mahdi, Onesimus Baharuldin, Mohamad Taufik Hidayat M. Nor, Nurul Huda Chiroma, Samaila Musa Jagadeesan, Saravanan Mohd Moklas, Mohamad Aris Background: Cannabis and its extracts are now being explored due to their huge health benefits. Although, the effect they elicit, whether on humans or rodents, may vary based on the age of the animal/subject and or the time in which the extract is administered. However, several debates exist concerning the various medical applications of these compounds. Nonetheless, their applicability as therapeutics should not be clouded based on their perceived negative biological actions. Methods: Articles from reliable databases such as Science Direct, PubMed, Google Scholar, Scopus, and Ovid were searched. Specific search methods were employed using multiple keywords: ''Medicinal Cannabis; endocannabinoid system; cannabinoids receptors; cannabinoids and cognition; brain disorders; neurodegenerative diseases''. For the inclusion/exclusion criteria, only relevant articles related to medicinal Cannabis and its various compounds were considered. Results: The current review highlights the role, effects, and involvement of Cannabis, cannabinoids, and endocannabinoids in preventing selected neurodegenerative diseases and possible amelioration of cognitive impairments. Furthermore, it also focuses on Cannabis utilization in many disease conditions such as Alzheimer's and Parkinson's disease among others. Conclusion: In conclusion, the usage of Cannabis should be further explored as accumulating evidence suggests that it could be effective and somewhat safe, especially when adhered to the recommended dosage. Furthermore, in-depth studies should be conducted in order to unravel the specific mechanism underpinning the involvement of cannabinoids at the cellular level and their therapeutic applications. Bentham Science Publishers 2021-01-27 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95542/1/The%20neuroprotective%20properties%2C%20functions.pdf Mahdi, Onesimus and Baharuldin, Mohamad Taufik Hidayat and M. Nor, Nurul Huda and Chiroma, Samaila Musa and Jagadeesan, Saravanan and Mohd Moklas, Mohamad Aris (2021) The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system. Central Nervous System Agents in Medicinal Chemistry, 21 (1). pp. 20-38. ISSN 1871-5249; ESSN: 1875-6166 https://www.eurekaselect.com/article/113707 10.2174/1871524921666210127110028
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: Cannabis and its extracts are now being explored due to their huge health benefits. Although, the effect they elicit, whether on humans or rodents, may vary based on the age of the animal/subject and or the time in which the extract is administered. However, several debates exist concerning the various medical applications of these compounds. Nonetheless, their applicability as therapeutics should not be clouded based on their perceived negative biological actions. Methods: Articles from reliable databases such as Science Direct, PubMed, Google Scholar, Scopus, and Ovid were searched. Specific search methods were employed using multiple keywords: ''Medicinal Cannabis; endocannabinoid system; cannabinoids receptors; cannabinoids and cognition; brain disorders; neurodegenerative diseases''. For the inclusion/exclusion criteria, only relevant articles related to medicinal Cannabis and its various compounds were considered. Results: The current review highlights the role, effects, and involvement of Cannabis, cannabinoids, and endocannabinoids in preventing selected neurodegenerative diseases and possible amelioration of cognitive impairments. Furthermore, it also focuses on Cannabis utilization in many disease conditions such as Alzheimer's and Parkinson's disease among others. Conclusion: In conclusion, the usage of Cannabis should be further explored as accumulating evidence suggests that it could be effective and somewhat safe, especially when adhered to the recommended dosage. Furthermore, in-depth studies should be conducted in order to unravel the specific mechanism underpinning the involvement of cannabinoids at the cellular level and their therapeutic applications.
format Article
author Mahdi, Onesimus
Baharuldin, Mohamad Taufik Hidayat
M. Nor, Nurul Huda
Chiroma, Samaila Musa
Jagadeesan, Saravanan
Mohd Moklas, Mohamad Aris
spellingShingle Mahdi, Onesimus
Baharuldin, Mohamad Taufik Hidayat
M. Nor, Nurul Huda
Chiroma, Samaila Musa
Jagadeesan, Saravanan
Mohd Moklas, Mohamad Aris
The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
author_facet Mahdi, Onesimus
Baharuldin, Mohamad Taufik Hidayat
M. Nor, Nurul Huda
Chiroma, Samaila Musa
Jagadeesan, Saravanan
Mohd Moklas, Mohamad Aris
author_sort Mahdi, Onesimus
title The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
title_short The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
title_full The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
title_fullStr The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
title_full_unstemmed The neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
title_sort neuroprotective properties, functions and roles of cannabis sativa in selected diseases related to the nervous system
publisher Bentham Science Publishers
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95542/1/The%20neuroprotective%20properties%2C%20functions.pdf
http://psasir.upm.edu.my/id/eprint/95542/
https://www.eurekaselect.com/article/113707
_version_ 1753789934074855424
score 13.211869

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