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The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder

The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits i...

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Main Authors: Nurul Iman, Ismail, Mohd Yusof, Nurul Aiman, Talib, Ummi Nasrah, Ahmad, Nur Aimi Zawami, Norazit, Anwar, Kumar, Jaya, Mehat, Muhammad Zulfadli, Jayabalan, Nanthini, Muthuraju, Sangu, Stefaniuk, Marzena, Kaczmarek, Leszek, Muzaimi, Mustapha
Format: Article
Language:English
Published: Frontiers Research Foundation 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf
http://psasir.upm.edu.my/id/eprint/95505/
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.683780/full
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spelling my.upm.eprints.955052022-12-28T08:37:23Z http://psasir.upm.edu.my/id/eprint/95505/ The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder Nurul Iman, Ismail Mohd Yusof, Nurul Aiman Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model. Frontiers Research Foundation 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf Nurul Iman, Ismail and Mohd Yusof, Nurul Aiman and Talib, Ummi Nasrah and Ahmad, Nur Aimi Zawami and Norazit, Anwar and Kumar, Jaya and Mehat, Muhammad Zulfadli and Jayabalan, Nanthini and Muthuraju, Sangu and Stefaniuk, Marzena and Kaczmarek, Leszek and Muzaimi, Mustapha (2021) The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder. Frontiers in Behavioral Neuroscience, 15 (-). pp. 1-13. ISSN ESSN:1662-5153 https://www.frontiersin.org/articles/10.3389/fnbeh.2021.683780/full 10.3389/fnbeh.2021.683780
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
format Article
author Nurul Iman, Ismail
Mohd Yusof, Nurul Aiman
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
spellingShingle Nurul Iman, Ismail
Mohd Yusof, Nurul Aiman
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
author_facet Nurul Iman, Ismail
Mohd Yusof, Nurul Aiman
Talib, Ummi Nasrah
Ahmad, Nur Aimi Zawami
Norazit, Anwar
Kumar, Jaya
Mehat, Muhammad Zulfadli
Jayabalan, Nanthini
Muthuraju, Sangu
Stefaniuk, Marzena
Kaczmarek, Leszek
Muzaimi, Mustapha
author_sort Nurul Iman, Ismail
title The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_short The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_full The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_fullStr The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_full_unstemmed The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
title_sort intellicage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
publisher Frontiers Research Foundation
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf
http://psasir.upm.edu.my/id/eprint/95505/
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.683780/full
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score 13.211869

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