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Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding

This study was designed to characterize telomere length and its regulatory genes and to evaluate their potential as well-being biomarkers. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and performances, organ weight, plasma CORT levels, telomere lengths and regulatory genes w...

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Main Authors: Badmus, Kazeem Ajasa, Idrus, Zulkifli, Goh, Yong Meng, Sazili, Awis Qurni, Mamat Hamidi, Kamalludin
Format: Article
Published: MDPI AG 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95310/
https://www.mdpi.com/2076-2615/11/10/2759
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spelling my.upm.eprints.953102023-04-11T08:29:18Z http://psasir.upm.edu.my/id/eprint/95310/ Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding Badmus, Kazeem Ajasa Idrus, Zulkifli Goh, Yong Meng Sazili, Awis Qurni Mamat Hamidi, Kamalludin This study was designed to characterize telomere length and its regulatory genes and to evaluate their potential as well-being biomarkers. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and performances, organ weight, plasma CORT levels, telomere lengths and regulatory genes were measured and recorded. Body weights of CORT-fed chickens were significantly suppressed (p < 0.05), and organ weights and circulating CORT plasma levels (p < 0.05) were altered. Interaction effect of CORT and duration was significant (p < 0.05) on heart and liver telomere length. CORT significantly (p < 0.05) shortened the telomere length of the whole blood, muscle, liver and heart. The TRF1, chTERT, TELO2 and HSF1 were significantly (p < 0.05) upregulated in the liver and heart at week 4 although these genes and TERRA were downregulated in the muscles at weeks 2 and 4. Therefore, telomere lengths and their regulators are associated and diverse, so they can be used as novel biomarkers of stress in broiler chickens fed with CORT. MDPI AG 2021-09-22 Article PeerReviewed Badmus, Kazeem Ajasa and Idrus, Zulkifli and Goh, Yong Meng and Sazili, Awis Qurni and Mamat Hamidi, Kamalludin (2021) Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding. Animals, 11 (10). art. no. 2759. pp. 1-18. ISSN 2076-2615 https://www.mdpi.com/2076-2615/11/10/2759 10.3390/ani11102759
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description This study was designed to characterize telomere length and its regulatory genes and to evaluate their potential as well-being biomarkers. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and performances, organ weight, plasma CORT levels, telomere lengths and regulatory genes were measured and recorded. Body weights of CORT-fed chickens were significantly suppressed (p < 0.05), and organ weights and circulating CORT plasma levels (p < 0.05) were altered. Interaction effect of CORT and duration was significant (p < 0.05) on heart and liver telomere length. CORT significantly (p < 0.05) shortened the telomere length of the whole blood, muscle, liver and heart. The TRF1, chTERT, TELO2 and HSF1 were significantly (p < 0.05) upregulated in the liver and heart at week 4 although these genes and TERRA were downregulated in the muscles at weeks 2 and 4. Therefore, telomere lengths and their regulators are associated and diverse, so they can be used as novel biomarkers of stress in broiler chickens fed with CORT.
format Article
author Badmus, Kazeem Ajasa
Idrus, Zulkifli
Goh, Yong Meng
Sazili, Awis Qurni
Mamat Hamidi, Kamalludin
spellingShingle Badmus, Kazeem Ajasa
Idrus, Zulkifli
Goh, Yong Meng
Sazili, Awis Qurni
Mamat Hamidi, Kamalludin
Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
author_facet Badmus, Kazeem Ajasa
Idrus, Zulkifli
Goh, Yong Meng
Sazili, Awis Qurni
Mamat Hamidi, Kamalludin
author_sort Badmus, Kazeem Ajasa
title Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
title_short Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
title_full Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
title_fullStr Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
title_full_unstemmed Telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
title_sort telomere length and regulatory genes as novel stress biomarkers and their diversities in broiler chickens (gallus gallus domesticus) subjected to corticosterone feeding
publisher MDPI AG
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95310/
https://www.mdpi.com/2076-2615/11/10/2759
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score 13.211869

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