Cover Image

Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury

Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored...

Full description

Saved in:
Bibliographic Details
Main Authors: Sakinah, S., Priya, Sivan Padma, Mok, Pooi Ling, Munisvaradass, Rusheni, Teh, Seoh Wei, Sun, Zhong, Chee, Hui-Yee, Hamat, Rukman Awang, Joseph, Narcisse, Tong, Jia Bei, Kumar, S. Suresh
Format: Article
Published: Frontiers Research Foundation 2021
Online Access:http://psasir.upm.edu.my/id/eprint/95158/
https://www.frontiersin.org/articles/10.3389/fcell.2021.637270/full
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.95158
record_format eprints
spelling my.upm.eprints.951582024-08-05T07:24:19Z http://psasir.upm.edu.my/id/eprint/95158/ Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury Sakinah, S. Priya, Sivan Padma Mok, Pooi Ling Munisvaradass, Rusheni Teh, Seoh Wei Sun, Zhong Chee, Hui-Yee Hamat, Rukman Awang Joseph, Narcisse Tong, Jia Bei Kumar, S. Suresh Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged tissues. In addition, the regime can regulate endothelial proliferation and permeability, modulate inflammatory reactions, enhance extracellular matrix production and angiogenesis, and secrete an array of growth factors to create an enhanced milieu for cell reparation. No previous study has been published on the treatment of dengue infection using stem cells combination. In conclusion, dengue-induced liver damage was rescued by administration of stem cell therapy, with less apoptosis and improved repair and regeneration in the dengue mouse model. Frontiers Research Foundation 2021 Article PeerReviewed Sakinah, S. and Priya, Sivan Padma and Mok, Pooi Ling and Munisvaradass, Rusheni and Teh, Seoh Wei and Sun, Zhong and Chee, Hui-Yee and Hamat, Rukman Awang and Joseph, Narcisse and Tong, Jia Bei and Kumar, S. Suresh (2021) Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury. Frontiers in Cell and Developmental Biology, 9. pp. 1-15. ISSN 2296-634X https://www.frontiersin.org/articles/10.3389/fcell.2021.637270/full 10.3389/fcell.2021.637270
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged tissues. In addition, the regime can regulate endothelial proliferation and permeability, modulate inflammatory reactions, enhance extracellular matrix production and angiogenesis, and secrete an array of growth factors to create an enhanced milieu for cell reparation. No previous study has been published on the treatment of dengue infection using stem cells combination. In conclusion, dengue-induced liver damage was rescued by administration of stem cell therapy, with less apoptosis and improved repair and regeneration in the dengue mouse model.
format Article
author Sakinah, S.
Priya, Sivan Padma
Mok, Pooi Ling
Munisvaradass, Rusheni
Teh, Seoh Wei
Sun, Zhong
Chee, Hui-Yee
Hamat, Rukman Awang
Joseph, Narcisse
Tong, Jia Bei
Kumar, S. Suresh
spellingShingle Sakinah, S.
Priya, Sivan Padma
Mok, Pooi Ling
Munisvaradass, Rusheni
Teh, Seoh Wei
Sun, Zhong
Chee, Hui-Yee
Hamat, Rukman Awang
Joseph, Narcisse
Tong, Jia Bei
Kumar, S. Suresh
Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
author_facet Sakinah, S.
Priya, Sivan Padma
Mok, Pooi Ling
Munisvaradass, Rusheni
Teh, Seoh Wei
Sun, Zhong
Chee, Hui-Yee
Hamat, Rukman Awang
Joseph, Narcisse
Tong, Jia Bei
Kumar, S. Suresh
author_sort Sakinah, S.
title Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
title_short Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
title_full Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
title_fullStr Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
title_full_unstemmed Stem cell therapy in dengue virus-infected BALB/C Mice improves hepatic injury
title_sort stem cell therapy in dengue virus-infected balb/c mice improves hepatic injury
publisher Frontiers Research Foundation
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/95158/
https://www.frontiersin.org/articles/10.3389/fcell.2021.637270/full
_version_ 1806690490154745856
score 13.211869

Similar Items