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Roles of Rho-associated kinase in lung cancer review

Lung cancer is one of the most lethal forms of cancer known to man, affecting millions of individuals worldwide. Despite advancements being made in lung cancer treatments, the prognosis of patients with the disease remains poor, particularly among patients with late‑stage lung cancer. The elucidatio...

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Main Authors: Zakaria, Muhammad Asyaari, Rajab, Nor Fadilah, Eng, Wee Chua, Selvarajah, Gayathri Thevi, Masre, Siti Fathiah
Format: Article
Published: Spandidos Publications 2020
Online Access:http://psasir.upm.edu.my/id/eprint/94996/
https://www.spandidos-publications.com/10.3892/ijo.2020.5164#
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spelling my.upm.eprints.949962023-01-09T03:20:14Z http://psasir.upm.edu.my/id/eprint/94996/ Roles of Rho-associated kinase in lung cancer review Zakaria, Muhammad Asyaari Rajab, Nor Fadilah Eng, Wee Chua Selvarajah, Gayathri Thevi Masre, Siti Fathiah Lung cancer is one of the most lethal forms of cancer known to man, affecting millions of individuals worldwide. Despite advancements being made in lung cancer treatments, the prognosis of patients with the disease remains poor, particularly among patients with late‑stage lung cancer. The elucidation of the signaling pathways involved in lung cancer is a critical approach for the treatment of the disease. Over the past decades, accumulating evidence has revealed that Rho‑associated kinase (ROCK) is overexpressed in lung cancer and is associated with tumor growth. The present review discusses recent findings of ROCK signaling in the pathogenesis of lung cancer that were conducted in pre‑clinical studies. The significant role of ROCK in cancer cell apoptosis, proliferation, migration, invasion and angiogenesis is discussed. The present review also suggests the use of ROCK as a potential target for the development of lung cancer therapies, as ROCK inhibition can reduce multiple hallmarks of cancer, particularly by decreasing cancer cell migration, which is an initial step of metastasis. Spandidos Publications 2020-12-24 Article PeerReviewed Zakaria, Muhammad Asyaari and Rajab, Nor Fadilah and Eng, Wee Chua and Selvarajah, Gayathri Thevi and Masre, Siti Fathiah (2020) Roles of Rho-associated kinase in lung cancer review. International Journal of Oncology, 58. 185 - 198. ISSN 1019-6439; ESSN: 1791-2423 https://www.spandidos-publications.com/10.3892/ijo.2020.5164# 10.3892/ijo.2020.5164
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Lung cancer is one of the most lethal forms of cancer known to man, affecting millions of individuals worldwide. Despite advancements being made in lung cancer treatments, the prognosis of patients with the disease remains poor, particularly among patients with late‑stage lung cancer. The elucidation of the signaling pathways involved in lung cancer is a critical approach for the treatment of the disease. Over the past decades, accumulating evidence has revealed that Rho‑associated kinase (ROCK) is overexpressed in lung cancer and is associated with tumor growth. The present review discusses recent findings of ROCK signaling in the pathogenesis of lung cancer that were conducted in pre‑clinical studies. The significant role of ROCK in cancer cell apoptosis, proliferation, migration, invasion and angiogenesis is discussed. The present review also suggests the use of ROCK as a potential target for the development of lung cancer therapies, as ROCK inhibition can reduce multiple hallmarks of cancer, particularly by decreasing cancer cell migration, which is an initial step of metastasis.
format Article
author Zakaria, Muhammad Asyaari
Rajab, Nor Fadilah
Eng, Wee Chua
Selvarajah, Gayathri Thevi
Masre, Siti Fathiah
spellingShingle Zakaria, Muhammad Asyaari
Rajab, Nor Fadilah
Eng, Wee Chua
Selvarajah, Gayathri Thevi
Masre, Siti Fathiah
Roles of Rho-associated kinase in lung cancer review
author_facet Zakaria, Muhammad Asyaari
Rajab, Nor Fadilah
Eng, Wee Chua
Selvarajah, Gayathri Thevi
Masre, Siti Fathiah
author_sort Zakaria, Muhammad Asyaari
title Roles of Rho-associated kinase in lung cancer review
title_short Roles of Rho-associated kinase in lung cancer review
title_full Roles of Rho-associated kinase in lung cancer review
title_fullStr Roles of Rho-associated kinase in lung cancer review
title_full_unstemmed Roles of Rho-associated kinase in lung cancer review
title_sort roles of rho-associated kinase in lung cancer review
publisher Spandidos Publications
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/94996/
https://www.spandidos-publications.com/10.3892/ijo.2020.5164#
_version_ 1754531205023268864
score 13.211869

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