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Palm oil consumption and its repercussion on endogenous fatty acids distribution

The consumption of saturated lipids in combination with a sedentary lifestyle increases the risk of obesity and metabolic syndrome. However, the distribution of endogenous fatty acids (FA) after the consumption of saturated lipids and the connection between FA distribution and lipid metabolism-relat...

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Main Authors: Li, Rui Zhi, Chen Cao, ., Zheng, Zhao Jun, Yang, Xiao Yan, Tan, Chin Ping, Xu, Yong Jiang, Liu, Yuan Fa
Format: Article
Published: Royal Society of Chemistry 2021
Online Access:http://psasir.upm.edu.my/id/eprint/94496/
https://pubs.rsc.org/en/content/articlelanding/2021/fo/d0fo02511a
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spelling my.upm.eprints.944962022-11-29T04:07:32Z http://psasir.upm.edu.my/id/eprint/94496/ Palm oil consumption and its repercussion on endogenous fatty acids distribution Li, Rui Zhi Chen Cao, . Zheng, Zhao Jun Yang, Xiao Yan Tan, Chin Ping Xu, Yong Jiang Liu, Yuan Fa The consumption of saturated lipids in combination with a sedentary lifestyle increases the risk of obesity and metabolic syndrome. However, the distribution of endogenous fatty acids (FA) after the consumption of saturated lipids and the connection between FA distribution and lipid metabolism-related genes relative expression have not been fully elucidated to date. In this study, we characterized FA profiles in the liver and visceral fats of Sprague Dawley (SD) rats fed with a high-palm-oil diet. The investigation showed that the levels of C16:0 and C18:1 (n-9) increased significantly (P < 0.05) in the liver of the high-palm-oil group (POG), while C16:1 (n-7) and C18:2 (n-6) accumulated markedly (P < 0.05) in the visceral fats of the control group (CN). A correlation analysis indicated a negative correlation between C16:0 and C16:1 (n-7) in the epididymal fat of POG. Our study also demonstrated that the intake of saturated lipids caused changes in lipid metabolism-related gene expression, especially stearoyl-CoA desaturase (SCD), which was upregulated at the third week but was inhibited in the subsequent weeks in the POG liver and perirenal fat. The SCD had a notable positive correlation with C16:1 (n-7) in the POG liver and perirenal fat but a significant negative correlation with C16:0 in the POG epididymal fat. In conclusion, the results of this study indicate that a high-C16:0 diet may result in adaptive SCD expression, and these findings may help to elucidate the effects of dietary fat on lipid metabolism. Royal Society of Chemistry 2021-01 Article PeerReviewed Li, Rui Zhi and Chen Cao, . and Zheng, Zhao Jun and Yang, Xiao Yan and Tan, Chin Ping and Xu, Yong Jiang and Liu, Yuan Fa (2021) Palm oil consumption and its repercussion on endogenous fatty acids distribution. Food & Function, 12 (5). 2020 - 2031. ISSN 2042-650X (Submitted) https://pubs.rsc.org/en/content/articlelanding/2021/fo/d0fo02511a 10.1039/D0FO02511A
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The consumption of saturated lipids in combination with a sedentary lifestyle increases the risk of obesity and metabolic syndrome. However, the distribution of endogenous fatty acids (FA) after the consumption of saturated lipids and the connection between FA distribution and lipid metabolism-related genes relative expression have not been fully elucidated to date. In this study, we characterized FA profiles in the liver and visceral fats of Sprague Dawley (SD) rats fed with a high-palm-oil diet. The investigation showed that the levels of C16:0 and C18:1 (n-9) increased significantly (P < 0.05) in the liver of the high-palm-oil group (POG), while C16:1 (n-7) and C18:2 (n-6) accumulated markedly (P < 0.05) in the visceral fats of the control group (CN). A correlation analysis indicated a negative correlation between C16:0 and C16:1 (n-7) in the epididymal fat of POG. Our study also demonstrated that the intake of saturated lipids caused changes in lipid metabolism-related gene expression, especially stearoyl-CoA desaturase (SCD), which was upregulated at the third week but was inhibited in the subsequent weeks in the POG liver and perirenal fat. The SCD had a notable positive correlation with C16:1 (n-7) in the POG liver and perirenal fat but a significant negative correlation with C16:0 in the POG epididymal fat. In conclusion, the results of this study indicate that a high-C16:0 diet may result in adaptive SCD expression, and these findings may help to elucidate the effects of dietary fat on lipid metabolism.
format Article
author Li, Rui Zhi
Chen Cao, .
Zheng, Zhao Jun
Yang, Xiao Yan
Tan, Chin Ping
Xu, Yong Jiang
Liu, Yuan Fa
spellingShingle Li, Rui Zhi
Chen Cao, .
Zheng, Zhao Jun
Yang, Xiao Yan
Tan, Chin Ping
Xu, Yong Jiang
Liu, Yuan Fa
Palm oil consumption and its repercussion on endogenous fatty acids distribution
author_facet Li, Rui Zhi
Chen Cao, .
Zheng, Zhao Jun
Yang, Xiao Yan
Tan, Chin Ping
Xu, Yong Jiang
Liu, Yuan Fa
author_sort Li, Rui Zhi
title Palm oil consumption and its repercussion on endogenous fatty acids distribution
title_short Palm oil consumption and its repercussion on endogenous fatty acids distribution
title_full Palm oil consumption and its repercussion on endogenous fatty acids distribution
title_fullStr Palm oil consumption and its repercussion on endogenous fatty acids distribution
title_full_unstemmed Palm oil consumption and its repercussion on endogenous fatty acids distribution
title_sort palm oil consumption and its repercussion on endogenous fatty acids distribution
publisher Royal Society of Chemistry
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/94496/
https://pubs.rsc.org/en/content/articlelanding/2021/fo/d0fo02511a
_version_ 1751538232846188544
score 13.211869

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