N-Arylation of protected and unprotected 5-Bromo-2-aminobenzimidazole as organic material: Non-Linear Optical (NLO) properties and structural feature determination through computational approach
The interest in the NLO response of organic compounds is growing rapidly, due to the ease of synthesis, availability, and low loss. Here, in this study, Cu(II)-catalyzed selective N-arylation of 2-aminobenzimidazoles derivatives were achieved in the presence of different bases Et3N/TMEDA, solvent...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
MDPI
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94333/ https://www.mdpi.com/1420-3049/26/22/6920 |
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| Summary: | The interest in the NLO response of organic compounds is growing rapidly, due to the ease
of synthesis, availability, and low loss. Here, in this study, Cu(II)-catalyzed selective N-arylation of
2-aminobenzimidazoles derivatives were achieved in the presence of different bases Et3N/TMEDA,
solvents DCM/MeOH/H2O, and various aryl boronic acids under open atmospheric conditions.
Two different copper-catalyzed pathways were selected for N-arylation in the presence of active
nucleophilic sites, providing a unique tool for the preparation of NLO materials, C-NH (aryl) derivatives of 2-aminobenzimidazoles with protection and without protection of NH2 group. In addition to
NMR analysis, all synthesized derivatives (1a–1f and 2a–2f) of 5-bromo-2-aminobenzimidazole (1)
were computed for their non-linear optical (NLO) properties and reactivity descriptor parameters.
Frontier molecular orbital (FMO) analysis was performed to get information about the electronic
properties and reactivity of synthesized compounds. |
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