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Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds

Obesity is growing at an alarming rate, which is characterized by increased adipose tissue. It increases the probability of many health complications, such as diabetes, arthritis, cardiac disease, and cancer. In modern society, with a growing population of obese patients, several individuals have in...

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Main Authors: Guru, Ajay, Issac, Praveen Kumar, Velayutham, Manikandan, Saraswathi, N. T., Arshad, Aziz, Arockiaraj, Jesu
Format: Article
Published: Springer 2021
Online Access:http://psasir.upm.edu.my/id/eprint/94255/
https://www.researchgate.net/publication/346648345_Molecular_mechanism_of_down-regulating_adipogenic_transcription_factors_in_3T3-L1_adipocyte_cells_by_bioactive_anti-adipogenic_compounds
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spelling my.upm.eprints.942552023-05-08T04:08:52Z http://psasir.upm.edu.my/id/eprint/94255/ Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds Guru, Ajay Issac, Praveen Kumar Velayutham, Manikandan Saraswathi, N. T. Arshad, Aziz Arockiaraj, Jesu Obesity is growing at an alarming rate, which is characterized by increased adipose tissue. It increases the probability of many health complications, such as diabetes, arthritis, cardiac disease, and cancer. In modern society, with a growing population of obese patients, several individuals have increased insulin resistance. Herbal medicines are known as the oldest method of health care treatment for obesity-related secondary health issues. Several traditional medicinal plants and their effective phytoconstituents have shown anti-diabetic and anti adipogenic activity. Adipose tissue is a major site for lipid accumulation as well as the whole-body insulin sensitivity region. 3T3-L1 cell line model can achieve adipogenesis. Adipocyte characteristics features such as expression of adipocyte markers and aggregation of lipids are chemically induced in the 3T3-L1 fibroblast cell line. Differentiation of 3T3-L1 is an efficient and convenient way to obtain adipocyte like cells in experimental studies. Peroxisome proliferation activated receptor γ (PPARγ) and Cytosine-Cytosine-Adenosine Adenosine-Thymidine/Enhancer-binding protein α (CCAAT/Enhancer-binding protein α or C/EBPα) are considered to be regulating adipogenesis at the early stage, while adiponectin and fatty acid synthase (FAS) is responsible for the mature adipocyte formation. Excess accumulation of these adipose tissues and lipids leads to obesity. Thus, investigating adipose tissue development and the underlying molecular mechanism is important in the therapeutical approach. This review describes the cellular mechanism of 3T3-L1 fibroblast cells on potential anti-adipogenic herbal bioactive compounds. Springer 2021-12-04 Article PeerReviewed Guru, Ajay and Issac, Praveen Kumar and Velayutham, Manikandan and Saraswathi, N. T. and Arshad, Aziz and Arockiaraj, Jesu (2021) Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds. Molecular Biology Reports, 48 (1). 743 - 761. ISSN 0301-4851; ESSN: 1573-4978 https://www.researchgate.net/publication/346648345_Molecular_mechanism_of_down-regulating_adipogenic_transcription_factors_in_3T3-L1_adipocyte_cells_by_bioactive_anti-adipogenic_compounds 10.1007/s11033-020-06036-8
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Obesity is growing at an alarming rate, which is characterized by increased adipose tissue. It increases the probability of many health complications, such as diabetes, arthritis, cardiac disease, and cancer. In modern society, with a growing population of obese patients, several individuals have increased insulin resistance. Herbal medicines are known as the oldest method of health care treatment for obesity-related secondary health issues. Several traditional medicinal plants and their effective phytoconstituents have shown anti-diabetic and anti adipogenic activity. Adipose tissue is a major site for lipid accumulation as well as the whole-body insulin sensitivity region. 3T3-L1 cell line model can achieve adipogenesis. Adipocyte characteristics features such as expression of adipocyte markers and aggregation of lipids are chemically induced in the 3T3-L1 fibroblast cell line. Differentiation of 3T3-L1 is an efficient and convenient way to obtain adipocyte like cells in experimental studies. Peroxisome proliferation activated receptor γ (PPARγ) and Cytosine-Cytosine-Adenosine Adenosine-Thymidine/Enhancer-binding protein α (CCAAT/Enhancer-binding protein α or C/EBPα) are considered to be regulating adipogenesis at the early stage, while adiponectin and fatty acid synthase (FAS) is responsible for the mature adipocyte formation. Excess accumulation of these adipose tissues and lipids leads to obesity. Thus, investigating adipose tissue development and the underlying molecular mechanism is important in the therapeutical approach. This review describes the cellular mechanism of 3T3-L1 fibroblast cells on potential anti-adipogenic herbal bioactive compounds.
format Article
author Guru, Ajay
Issac, Praveen Kumar
Velayutham, Manikandan
Saraswathi, N. T.
Arshad, Aziz
Arockiaraj, Jesu
spellingShingle Guru, Ajay
Issac, Praveen Kumar
Velayutham, Manikandan
Saraswathi, N. T.
Arshad, Aziz
Arockiaraj, Jesu
Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
author_facet Guru, Ajay
Issac, Praveen Kumar
Velayutham, Manikandan
Saraswathi, N. T.
Arshad, Aziz
Arockiaraj, Jesu
author_sort Guru, Ajay
title Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
title_short Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
title_full Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
title_fullStr Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
title_full_unstemmed Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds
title_sort molecular mechanism of down-regulating adipogenic transcription factors in 3t3-l1 adipocyte cells by bioactive anti-adipogenic compounds
publisher Springer
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/94255/
https://www.researchgate.net/publication/346648345_Molecular_mechanism_of_down-regulating_adipogenic_transcription_factors_in_3T3-L1_adipocyte_cells_by_bioactive_anti-adipogenic_compounds
_version_ 1768009393983455232
score 13.211869

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