Staff View: Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia

Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia

The Katjang goat is the only indigenous domestic goat breed in Malaysia. Following a national baseline survey from 2001 to 2002, this breed was reported to the FAO as being at risk of extinction. In this study, 36 microsatellite markers were screened, and 25 polymorphic markers were used to analyze...

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Main Authors:	Mohd Adhan, Ernie Muneerah, Md Tamrin, Nur Aida, Salisi, Mohd Shahrom, Zulkifly, Shahrizim, Ghazali, Siti Shaidatul Maisarah, Temuli, Jackson Jenun, Rosali, Mohd Hifzan, Nazari, Shariffah, Wan Nik, Wan Mohd Kamil, Kamalludin, Mamat Hamidi
Format:	Article
Published:	MDPI 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/94186/ https://www.mdpi.com/2076-2615/11/5/1328
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spelling	my.upm.eprints.941862023-05-09T03:11:39Z http://psasir.upm.edu.my/id/eprint/94186/ Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia Mohd Adhan, Ernie Muneerah Md Tamrin, Nur Aida Salisi, Mohd Shahrom Zulkifly, Shahrizim Ghazali, Siti Shaidatul Maisarah Temuli, Jackson Jenun Rosali, Mohd Hifzan Nazari, Shariffah Wan Nik, Wan Mohd Kamil Kamalludin, Mamat Hamidi The Katjang goat is the only indigenous domestic goat breed in Malaysia. Following a national baseline survey from 2001 to 2002, this breed was reported to the FAO as being at risk of extinction. In this study, 36 microsatellite markers were screened, and 25 polymorphic markers were used to analyze the genetic structure of the Katjang goat breed in Peninsular Malaysia. A sample set of data derived from another 10 populations from three published research studies was used as an outgroup for an inter-population genetic study. The analysis showed that the mean value of the observed heterozygosity was 0.29 ± 0.14, and the expected heterozygosity was 0.72 ± 0.14, which indicated low genetic diversity. The inbreeding coefficient, FIS, was high, at 0.46. Significant (p < 0.01) deviations from the Hardy Weinberg equilibrium were noted for all loci. The bottleneck analysis using the Wilcoxon Rank test under the two-phase model of mutation was significant (p < 0.01) for heterozygosity excess, which suggested that the Katjang breed had undergone significant population reduction in the past. Through combined analysis of data from publicly available research, almost the entire population of Katjang goats represent the centroid and are grouped together on a multidimensional scaling plot, except for the Terengganu population. Network analysis revealed that the goat population from Pahang formed the centrality of the network. MDPI 2021-05-07 Article PeerReviewed Mohd Adhan, Ernie Muneerah and Md Tamrin, Nur Aida and Salisi, Mohd Shahrom and Zulkifly, Shahrizim and Ghazali, Siti Shaidatul Maisarah and Temuli, Jackson Jenun and Rosali, Mohd Hifzan and Nazari, Shariffah and Wan Nik, Wan Mohd Kamil and Kamalludin, Mamat Hamidi (2021) Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia. Animal, 11 (5). art. no. 1328. pp. 1-15. ISSN 2076-2615 https://www.mdpi.com/2076-2615/11/5/1328 10.3390/ani11051328
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	The Katjang goat is the only indigenous domestic goat breed in Malaysia. Following a national baseline survey from 2001 to 2002, this breed was reported to the FAO as being at risk of extinction. In this study, 36 microsatellite markers were screened, and 25 polymorphic markers were used to analyze the genetic structure of the Katjang goat breed in Peninsular Malaysia. A sample set of data derived from another 10 populations from three published research studies was used as an outgroup for an inter-population genetic study. The analysis showed that the mean value of the observed heterozygosity was 0.29 ± 0.14, and the expected heterozygosity was 0.72 ± 0.14, which indicated low genetic diversity. The inbreeding coefficient, FIS, was high, at 0.46. Significant (p < 0.01) deviations from the Hardy Weinberg equilibrium were noted for all loci. The bottleneck analysis using the Wilcoxon Rank test under the two-phase model of mutation was significant (p < 0.01) for heterozygosity excess, which suggested that the Katjang breed had undergone significant population reduction in the past. Through combined analysis of data from publicly available research, almost the entire population of Katjang goats represent the centroid and are grouped together on a multidimensional scaling plot, except for the Terengganu population. Network analysis revealed that the goat population from Pahang formed the centrality of the network.
format	Article
author	Mohd Adhan, Ernie Muneerah Md Tamrin, Nur Aida Salisi, Mohd Shahrom Zulkifly, Shahrizim Ghazali, Siti Shaidatul Maisarah Temuli, Jackson Jenun Rosali, Mohd Hifzan Nazari, Shariffah Wan Nik, Wan Mohd Kamil Kamalludin, Mamat Hamidi
spellingShingle	Mohd Adhan, Ernie Muneerah Md Tamrin, Nur Aida Salisi, Mohd Shahrom Zulkifly, Shahrizim Ghazali, Siti Shaidatul Maisarah Temuli, Jackson Jenun Rosali, Mohd Hifzan Nazari, Shariffah Wan Nik, Wan Mohd Kamil Kamalludin, Mamat Hamidi Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
author_facet	Mohd Adhan, Ernie Muneerah Md Tamrin, Nur Aida Salisi, Mohd Shahrom Zulkifly, Shahrizim Ghazali, Siti Shaidatul Maisarah Temuli, Jackson Jenun Rosali, Mohd Hifzan Nazari, Shariffah Wan Nik, Wan Mohd Kamil Kamalludin, Mamat Hamidi
author_sort	Mohd Adhan, Ernie Muneerah
title	Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
title_short	Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
title_full	Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
title_fullStr	Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
title_full_unstemmed	Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia
title_sort	microsatellite-based genetic characterization of the indigenous katjang goat in peninsular malaysia
publisher	MDPI
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/94186/ https://www.mdpi.com/2076-2615/11/5/1328
_version_	1768009384298807296
score	13.211869

Microsatellite-based genetic characterization of the indigenous Katjang goat in Peninsular Malaysia

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