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Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication

Initially, retinol-binding protein (RBP), was thought to be a biomarker for proximal convoluted tubule dysfunction could be important in chronic kidney diseases (CKD). Membranous glomerulonephritis (MGN) is an important cause of CKD and end-stage renal disease (ESRD). Therefore, monitoring MGN patie...

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Main Authors: Maifata, Sadiq Muazu, Abd Ghani, Fauzah, Hod, Rafidah, Zakaria, Nor Fadhlina
Format: Article
Published: MDPI 2021
Online Access:http://psasir.upm.edu.my/id/eprint/94149/
https://www.preprints.org/manuscript/202108.0109/v1
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spelling my.upm.eprints.941492023-05-23T02:29:34Z http://psasir.upm.edu.my/id/eprint/94149/ Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication Maifata, Sadiq Muazu Abd Ghani, Fauzah Hod, Rafidah Zakaria, Nor Fadhlina Initially, retinol-binding protein (RBP), was thought to be a biomarker for proximal convoluted tubule dysfunction could be important in chronic kidney diseases (CKD). Membranous glomerulonephritis (MGN) is an important cause of CKD and end-stage renal disease (ESRD). Therefore, monitoring MGN patients using urinary RBP is important in effective treatment decision making and prognostication of MGN patients. Enzyme-linked immunosorbent assay (ELISA) technique was used to detect the RBP in the urine samples of 69 MGN patients comprising 47 primary and 22 secondary MGN, at the end of the follow-up period. The test for the urinary biomarker gave the following results: urinary RBP was detected in 27 (39.1%) and 6 (8.7%) of the primary and secondary MGN patients, respectively. The correlation analysis demonstrated a significant relationship between urinary RBP and renal function test parameters, in addition to a logistic regression analysis that proved urinary RBP as a prognostic non-invasive biomarker for primary MGN. Therefore, urinary RBP could be employed to monitor and provide effective prognosis and early treatment decisions in primary MGN. MDPI 2021-08-04 Article PeerReviewed Maifata, Sadiq Muazu and Abd Ghani, Fauzah and Hod, Rafidah and Zakaria, Nor Fadhlina (2021) Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication. Preprints. pp. 1-8. ISSN 2310-287X https://www.preprints.org/manuscript/202108.0109/v1 10.20944/preprints202108.0109.v1.
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Initially, retinol-binding protein (RBP), was thought to be a biomarker for proximal convoluted tubule dysfunction could be important in chronic kidney diseases (CKD). Membranous glomerulonephritis (MGN) is an important cause of CKD and end-stage renal disease (ESRD). Therefore, monitoring MGN patients using urinary RBP is important in effective treatment decision making and prognostication of MGN patients. Enzyme-linked immunosorbent assay (ELISA) technique was used to detect the RBP in the urine samples of 69 MGN patients comprising 47 primary and 22 secondary MGN, at the end of the follow-up period. The test for the urinary biomarker gave the following results: urinary RBP was detected in 27 (39.1%) and 6 (8.7%) of the primary and secondary MGN patients, respectively. The correlation analysis demonstrated a significant relationship between urinary RBP and renal function test parameters, in addition to a logistic regression analysis that proved urinary RBP as a prognostic non-invasive biomarker for primary MGN. Therefore, urinary RBP could be employed to monitor and provide effective prognosis and early treatment decisions in primary MGN.
format Article
author Maifata, Sadiq Muazu
Abd Ghani, Fauzah
Hod, Rafidah
Zakaria, Nor Fadhlina
spellingShingle Maifata, Sadiq Muazu
Abd Ghani, Fauzah
Hod, Rafidah
Zakaria, Nor Fadhlina
Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
author_facet Maifata, Sadiq Muazu
Abd Ghani, Fauzah
Hod, Rafidah
Zakaria, Nor Fadhlina
author_sort Maifata, Sadiq Muazu
title Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
title_short Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
title_full Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
title_fullStr Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
title_full_unstemmed Membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
title_sort membranous glomerulonephritis: role of retinol-binding protein in monitoring and prognostication
publisher MDPI
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/94149/
https://www.preprints.org/manuscript/202108.0109/v1
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score 13.211869

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