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Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst...

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Main Authors: Mohd Nordin, Ummu Umaimah, Ahmad, Noraini, Salim, Norazlinaliza, Mohd Yusof, Nor Saadah
Format: Article
Published: Royal Society of Chemistry 2021
Online Access:http://psasir.upm.edu.my/id/eprint/94039/
https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra06087b
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spelling my.upm.eprints.940392023-04-12T01:23:57Z http://psasir.upm.edu.my/id/eprint/94039/ Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects Mohd Nordin, Ummu Umaimah Ahmad, Noraini Salim, Norazlinaliza Mohd Yusof, Nor Saadah Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs. Royal Society of Chemistry 2021-09-01 Article PeerReviewed Mohd Nordin, Ummu Umaimah and Ahmad, Noraini and Salim, Norazlinaliza and Mohd Yusof, Nor Saadah (2021) Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects. RSC Advances, 11. 29080 - 29101. ISSN 2045-547X; ESSN: 2046-2069 https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra06087b 10.1039/d1ra06087b
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs.
format Article
author Mohd Nordin, Ummu Umaimah
Ahmad, Noraini
Salim, Norazlinaliza
Mohd Yusof, Nor Saadah
spellingShingle Mohd Nordin, Ummu Umaimah
Ahmad, Noraini
Salim, Norazlinaliza
Mohd Yusof, Nor Saadah
Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
author_facet Mohd Nordin, Ummu Umaimah
Ahmad, Noraini
Salim, Norazlinaliza
Mohd Yusof, Nor Saadah
author_sort Mohd Nordin, Ummu Umaimah
title Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
title_short Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
title_full Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
title_fullStr Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
title_full_unstemmed Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
title_sort lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
publisher Royal Society of Chemistry
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/94039/
https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra06087b
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score 13.211869

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