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Updates on molecular and biochemical development and progression of prostate cancer

Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite th...

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Main Authors: Fahmy, Omar, A. Alhakamy, Nabil, Y. Rizg, Waleed, Bagalagel, Alaa, J. Alamoudi, Abdulmohsin, M. Aldawsari, Hibah, M. Khateb, Aiah, M. Eldakhakhny, Basmah, A. Fahmy, Usama, H. Abdulaal, Wesam, G. Fresta, Claudia, Caruso, Giuseppe
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Published: MDPI 2021
Online Access:http://psasir.upm.edu.my/id/eprint/93493/
https://www.mdpi.com/2077-0383/10/21/5127
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spelling my.upm.eprints.934932023-01-13T03:33:28Z http://psasir.upm.edu.my/id/eprint/93493/ Updates on molecular and biochemical development and progression of prostate cancer Fahmy, Omar A. Alhakamy, Nabil Y. Rizg, Waleed Bagalagel, Alaa J. Alamoudi, Abdulmohsin M. Aldawsari, Hibah M. Khateb, Aiah M. Eldakhakhny, Basmah A. Fahmy, Usama H. Abdulaal, Wesam G. Fresta, Claudia Caruso, Giuseppe Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment. MDPI 2021-10-31 Article PeerReviewed Fahmy, Omar and A. Alhakamy, Nabil and Y. Rizg, Waleed and Bagalagel, Alaa and J. Alamoudi, Abdulmohsin and M. Aldawsari, Hibah and M. Khateb, Aiah and M. Eldakhakhny, Basmah and A. Fahmy, Usama and H. Abdulaal, Wesam and G. Fresta, Claudia and Caruso, Giuseppe (2021) Updates on molecular and biochemical development and progression of prostate cancer. Journal of Clinical Medicine, 10 (21). pp. 1-13. ISSN 2077-0383 https://www.mdpi.com/2077-0383/10/21/5127 10.3390/jcm10215127
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment.
format Article
author Fahmy, Omar
A. Alhakamy, Nabil
Y. Rizg, Waleed
Bagalagel, Alaa
J. Alamoudi, Abdulmohsin
M. Aldawsari, Hibah
M. Khateb, Aiah
M. Eldakhakhny, Basmah
A. Fahmy, Usama
H. Abdulaal, Wesam
G. Fresta, Claudia
Caruso, Giuseppe
spellingShingle Fahmy, Omar
A. Alhakamy, Nabil
Y. Rizg, Waleed
Bagalagel, Alaa
J. Alamoudi, Abdulmohsin
M. Aldawsari, Hibah
M. Khateb, Aiah
M. Eldakhakhny, Basmah
A. Fahmy, Usama
H. Abdulaal, Wesam
G. Fresta, Claudia
Caruso, Giuseppe
Updates on molecular and biochemical development and progression of prostate cancer
author_facet Fahmy, Omar
A. Alhakamy, Nabil
Y. Rizg, Waleed
Bagalagel, Alaa
J. Alamoudi, Abdulmohsin
M. Aldawsari, Hibah
M. Khateb, Aiah
M. Eldakhakhny, Basmah
A. Fahmy, Usama
H. Abdulaal, Wesam
G. Fresta, Claudia
Caruso, Giuseppe
author_sort Fahmy, Omar
title Updates on molecular and biochemical development and progression of prostate cancer
title_short Updates on molecular and biochemical development and progression of prostate cancer
title_full Updates on molecular and biochemical development and progression of prostate cancer
title_fullStr Updates on molecular and biochemical development and progression of prostate cancer
title_full_unstemmed Updates on molecular and biochemical development and progression of prostate cancer
title_sort updates on molecular and biochemical development and progression of prostate cancer
publisher MDPI
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/93493/
https://www.mdpi.com/2077-0383/10/21/5127
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score 13.211869

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