Staff View: Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease

Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease

A 66-year-old man with underlying hypertension and dyslipidemia presented with left hand tremor for one year. He also noticed difficulty in initiating movement and slowness in activities of daily living. On examination, he was noted to have mask-like facies with reduced blinking and monotonous speec...

Full description

Saved in:

Bibliographic Details
Main Authors:	Abd Rashid, Anna Misyail, Md Noh, Mohamad Syafeeq Faeez, Yusof Khan, Abdul Hanif Khan, Mohd Yaakob, Mohd Naim, Bahari, Norafida, Basri, Hamidon
Format:	Article
Published:	Longe Medikal 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/93482/ https://mycvns.com/index.php/journal/article/view/66
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.upm.eprints.93482
record_format	eprints
spelling	my.upm.eprints.934822023-09-12T02:17:01Z http://psasir.upm.edu.my/id/eprint/93482/ Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease Abd Rashid, Anna Misyail Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Mohd Yaakob, Mohd Naim Bahari, Norafida Basri, Hamidon A 66-year-old man with underlying hypertension and dyslipidemia presented with left hand tremor for one year. He also noticed difficulty in initiating movement and slowness in activities of daily living. On examination, he was noted to have mask-like facies with reduced blinking and monotonous speech. There was presence of resting pill-rolling tremor, bradykinesia, and cogwheel rigidity which was worst on the left upper limb. Gait assessment revealed difficulty in standing up, shuffling gait with reduced arm swing which was more prominent on the left side, and turning in numbers. No cerebellar signs and supranuclear palsy were present to suggest Parkinson-plus syndrome. Susceptibility weighted imaging (SWI) showed loss of the swallow tail sign on the right side [Figure 1]. The clinical presentation, supplemented by the imaging findings were concluded to be pathognomonic of idiopathic Parkinson’s disease (IPD), Hoehn & Yahr stage 1. He was started on levodopa and benserazide twice daily with improvement of symptoms. The nigrosomes are primary subregions of the substantia nigra where dopaminergic cells are lost in IPD. Within these nigrosomes, maximal cell loss occurs in nigrosome-1; the largest subgroup of nigrosomes. Normally, they appear as a SWI-hyperintense area surrounded by hypointensity within the dorsolateral substantia nigra, akin to a swallow’s tail. In one study, poor visualization of nigrosome-1 was significantly associated with higher motor asymmetry in the contralateral side (sensitivity 98.5%, specificity 93.6%, positive-predictive value 98.3%, negative-predictive value 98.3% and an accuracy of 96%) [1]. Noh et al [2] showed that abnormality involving nigrosome-1 can be detected at 3T MR imaging with an accuracy of 94.6%. Due to the difficulty in diagnosis of early stage IPD, a loss of the swallow tail sign serves as a useful imaging biomarker to supplement the clinical diagnosis, as seen in our patient. Longe Medikal 2021-09-03 Article PeerReviewed Abd Rashid, Anna Misyail and Md Noh, Mohamad Syafeeq Faeez and Yusof Khan, Abdul Hanif Khan and Mohd Yaakob, Mohd Naim and Bahari, Norafida and Basri, Hamidon (2021) Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease. Journal of Cardiovascular, Neurovascular & Stroke, 3 (3). 1 - 1196. ISSN 2600-7800; ESSN: 2600-7800 https://mycvns.com/index.php/journal/article/view/66 10.32896/cvns.v3n3.59-62
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	A 66-year-old man with underlying hypertension and dyslipidemia presented with left hand tremor for one year. He also noticed difficulty in initiating movement and slowness in activities of daily living. On examination, he was noted to have mask-like facies with reduced blinking and monotonous speech. There was presence of resting pill-rolling tremor, bradykinesia, and cogwheel rigidity which was worst on the left upper limb. Gait assessment revealed difficulty in standing up, shuffling gait with reduced arm swing which was more prominent on the left side, and turning in numbers. No cerebellar signs and supranuclear palsy were present to suggest Parkinson-plus syndrome. Susceptibility weighted imaging (SWI) showed loss of the swallow tail sign on the right side [Figure 1]. The clinical presentation, supplemented by the imaging findings were concluded to be pathognomonic of idiopathic Parkinson’s disease (IPD), Hoehn & Yahr stage 1. He was started on levodopa and benserazide twice daily with improvement of symptoms. The nigrosomes are primary subregions of the substantia nigra where dopaminergic cells are lost in IPD. Within these nigrosomes, maximal cell loss occurs in nigrosome-1; the largest subgroup of nigrosomes. Normally, they appear as a SWI-hyperintense area surrounded by hypointensity within the dorsolateral substantia nigra, akin to a swallow’s tail. In one study, poor visualization of nigrosome-1 was significantly associated with higher motor asymmetry in the contralateral side (sensitivity 98.5%, specificity 93.6%, positive-predictive value 98.3%, negative-predictive value 98.3% and an accuracy of 96%) [1]. Noh et al [2] showed that abnormality involving nigrosome-1 can be detected at 3T MR imaging with an accuracy of 94.6%. Due to the difficulty in diagnosis of early stage IPD, a loss of the swallow tail sign serves as a useful imaging biomarker to supplement the clinical diagnosis, as seen in our patient.
format	Article
author	Abd Rashid, Anna Misyail Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Mohd Yaakob, Mohd Naim Bahari, Norafida Basri, Hamidon
spellingShingle	Abd Rashid, Anna Misyail Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Mohd Yaakob, Mohd Naim Bahari, Norafida Basri, Hamidon Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
author_facet	Abd Rashid, Anna Misyail Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Mohd Yaakob, Mohd Naim Bahari, Norafida Basri, Hamidon
author_sort	Abd Rashid, Anna Misyail
title	Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
title_short	Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
title_full	Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
title_fullStr	Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
title_full_unstemmed	Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease
title_sort	unilateral loss of the swallow tail sign in a patient with idiopathic parkinson’s disease
publisher	Longe Medikal
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/93482/ https://mycvns.com/index.php/journal/article/view/66
_version_	1778163732245905408
score	13.211869

Unilateral loss of the swallow tail sign in a patient with idiopathic Parkinson’s disease

Similar Items