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Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study

Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury A...

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Main Authors: Rusli, Nur Syahfinaz Hidayah, Zakaria, Faikah, Abdul Razak, Hairil Rashmizal
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021
Online Access:http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf
http://psasir.upm.edu.my/id/eprint/90341/
https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf
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spelling my.upm.eprints.903412021-09-09T23:43:28Z http://psasir.upm.edu.my/id/eprint/90341/ Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf Rusli, Nur Syahfinaz Hidayah and Zakaria, Faikah and Abdul Razak, Hairil Rashmizal (2021) Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study. Malaysian Journal of Medicine and Health Sciences, 17 (2). pp. 4-10. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise.
format Article
author Rusli, Nur Syahfinaz Hidayah
Zakaria, Faikah
Abdul Razak, Hairil Rashmizal
spellingShingle Rusli, Nur Syahfinaz Hidayah
Zakaria, Faikah
Abdul Razak, Hairil Rashmizal
Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
author_facet Rusli, Nur Syahfinaz Hidayah
Zakaria, Faikah
Abdul Razak, Hairil Rashmizal
author_sort Rusli, Nur Syahfinaz Hidayah
title Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
title_short Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
title_full Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
title_fullStr Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
title_full_unstemmed Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 H-MRS) for incomplete spinal cord injury patients: preliminary study
title_sort quantification of muscle metabolites using proton magnetic resonance spectroscopy (1 h-mrs) for incomplete spinal cord injury patients: preliminary study
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/90341/1/2021040610445401_MJMHS_0348.pdf
http://psasir.upm.edu.my/id/eprint/90341/
https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf
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score 13.211869

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