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Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity

Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in th...

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Main Authors: Mohan, Subhatharshni, Abdul Rahim, Nazatul Shima, Salleh, Amizatul Aini, Mahayidin, Hasni, Bakrin, Ikmal Hisyam
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020
Online Access:http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf
http://psasir.upm.edu.my/id/eprint/90201/
https://medic.upm.edu.my/upload/dokumen/2020110611242820_2020_0345.pdf
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spelling my.upm.eprints.902012021-09-09T21:22:28Z http://psasir.upm.edu.my/id/eprint/90201/ Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity Mohan, Subhatharshni Abdul Rahim, Nazatul Shima Salleh, Amizatul Aini Mahayidin, Hasni Bakrin, Ikmal Hisyam Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic dermatological features including non-bullous manifestations and blisters. Therefore, a wide range of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS) which has led to withdrawal of his oral chemotherapy treatment. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf Mohan, Subhatharshni and Abdul Rahim, Nazatul Shima and Salleh, Amizatul Aini and Mahayidin, Hasni and Bakrin, Ikmal Hisyam (2020) Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 127-130. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611242820_2020_0345.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic dermatological features including non-bullous manifestations and blisters. Therefore, a wide range of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS) which has led to withdrawal of his oral chemotherapy treatment.
format Article
author Mohan, Subhatharshni
Abdul Rahim, Nazatul Shima
Salleh, Amizatul Aini
Mahayidin, Hasni
Bakrin, Ikmal Hisyam
spellingShingle Mohan, Subhatharshni
Abdul Rahim, Nazatul Shima
Salleh, Amizatul Aini
Mahayidin, Hasni
Bakrin, Ikmal Hisyam
Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
author_facet Mohan, Subhatharshni
Abdul Rahim, Nazatul Shima
Salleh, Amizatul Aini
Mahayidin, Hasni
Bakrin, Ikmal Hisyam
author_sort Mohan, Subhatharshni
title Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
title_short Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
title_full Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
title_fullStr Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
title_full_unstemmed Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
title_sort paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf
http://psasir.upm.edu.my/id/eprint/90201/
https://medic.upm.edu.my/upload/dokumen/2020110611242820_2020_0345.pdf
_version_ 1712286765813858304
score 13.211869

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