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Prolonged neonatal jaundice with deranged thyroid function test

Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low...

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Main Authors: Choo, Jin Earn, Chellappah Thambiah, Subashini, Samsudin, Intan Nureslyna
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020
Online Access:http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf
http://psasir.upm.edu.my/id/eprint/90198/
https://medic.upm.edu.my/upload/dokumen/2020110611223317_2020_0248.pdf
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spelling my.upm.eprints.901982021-09-09T11:29:55Z http://psasir.upm.edu.my/id/eprint/90198/ Prolonged neonatal jaundice with deranged thyroid function test Choo, Jin Earn Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low or normal TSH levels after excluding all other causes of discordant thyroid function test (TFT). Here, we report a case of a baby girl who presented with prolonged jaundice at day 15 of life with normal cord blood TSH performed as routine screening for congenital hypothyroidism. Serial TFT revealed declining serum fT4 with normal TSH consistent with CCH. Her jaundice resolved prior to levothyroxine replacement. CCH is commonly missed on cord blood TSH-based newborn screening leading to a delay in diagnosis, potentially resulting in neurodevelopmental delay. Hence, although CCH has a lower incidence than congenital primary hypothyroidism, a high index of suspicion is essential for timely diagnosis. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf Choo, Jin Earn and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna (2020) Prolonged neonatal jaundice with deranged thyroid function test. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 117-119. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611223317_2020_0248.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low or normal TSH levels after excluding all other causes of discordant thyroid function test (TFT). Here, we report a case of a baby girl who presented with prolonged jaundice at day 15 of life with normal cord blood TSH performed as routine screening for congenital hypothyroidism. Serial TFT revealed declining serum fT4 with normal TSH consistent with CCH. Her jaundice resolved prior to levothyroxine replacement. CCH is commonly missed on cord blood TSH-based newborn screening leading to a delay in diagnosis, potentially resulting in neurodevelopmental delay. Hence, although CCH has a lower incidence than congenital primary hypothyroidism, a high index of suspicion is essential for timely diagnosis.
format Article
author Choo, Jin Earn
Chellappah Thambiah, Subashini
Samsudin, Intan Nureslyna
spellingShingle Choo, Jin Earn
Chellappah Thambiah, Subashini
Samsudin, Intan Nureslyna
Prolonged neonatal jaundice with deranged thyroid function test
author_facet Choo, Jin Earn
Chellappah Thambiah, Subashini
Samsudin, Intan Nureslyna
author_sort Choo, Jin Earn
title Prolonged neonatal jaundice with deranged thyroid function test
title_short Prolonged neonatal jaundice with deranged thyroid function test
title_full Prolonged neonatal jaundice with deranged thyroid function test
title_fullStr Prolonged neonatal jaundice with deranged thyroid function test
title_full_unstemmed Prolonged neonatal jaundice with deranged thyroid function test
title_sort prolonged neonatal jaundice with deranged thyroid function test
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf
http://psasir.upm.edu.my/id/eprint/90198/
https://medic.upm.edu.my/upload/dokumen/2020110611223317_2020_0248.pdf
_version_ 1710677200344186880
score 13.211869

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