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Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma

Introduction: Endometrial carcinoma is the most common gynaecological malignancy in developed countries and the sixth most common cancer among women worldwide. Cancer staging is vital in treatment decisions and the prediction of prognoses, and is based on imaging studies, histological results and su...

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Main Authors: Abu Bakar, Nur Aini, Osman, Malina, Hussin, Huzlinda
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020
Online Access:http://psasir.upm.edu.my/id/eprint/90193/1/12upm.pdf
http://psasir.upm.edu.my/id/eprint/90193/
https://medic.upm.edu.my/upload/dokumen/2020110611191512_2020_0485.pdf
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spelling my.upm.eprints.901932021-09-08T22:45:34Z http://psasir.upm.edu.my/id/eprint/90193/ Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma Abu Bakar, Nur Aini Osman, Malina Hussin, Huzlinda Introduction: Endometrial carcinoma is the most common gynaecological malignancy in developed countries and the sixth most common cancer among women worldwide. Cancer staging is vital in treatment decisions and the prediction of prognoses, and is based on imaging studies, histological results and surgery. Therefore, a simple and fast preoperative tool to predict the precise cancer stage of patients is needed. CA 125, a cancer antigen, is used in assessing therapeutic response and cancer surveillance in endometrial carcinoma. However, this tumour marker is not routinely performed in the mentioned circumstances. Studies have shown that preoperative CA 125 was significantly high in patients in a higher stage of endometrial cancer. Thus, this study aims to assess the primary role of CA 125 in predicting the stage of endometrial carcinoma, by correlating preoperative serum CA 125 with clinicopathological parameters. Method: The retrospective data of endometrial carcinoma cases consisting of demographic and clinicopathological parameters as well as preoperative serum CA 125 levels were retrieved from Laboratories Information System (LIS) at Hospital Selayang, Selangor, Malaysia, from January 2000 until June 2016. Only 20 cases fulfilled the inclusion and exclusion criteria. Preoperative serum CA 125 was correlated with demographic and clinicopathological parameters, and was analysed using a Kruskal-Wallis test. Results: There was a significant association between elevated serum CA 125 with myometrial and cervical stroma invasion in endometrial carcinoma (p<0.05 )Conclusion: Preoperative serum CA 125 is a useful marker in predicting early stages of endometrial carcinoma, and plays a role in pre-operative cancer staging in endometrial carcinoma. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90193/1/12upm.pdf Abu Bakar, Nur Aini and Osman, Malina and Hussin, Huzlinda (2020) Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 75-81. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611191512_2020_0485.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Endometrial carcinoma is the most common gynaecological malignancy in developed countries and the sixth most common cancer among women worldwide. Cancer staging is vital in treatment decisions and the prediction of prognoses, and is based on imaging studies, histological results and surgery. Therefore, a simple and fast preoperative tool to predict the precise cancer stage of patients is needed. CA 125, a cancer antigen, is used in assessing therapeutic response and cancer surveillance in endometrial carcinoma. However, this tumour marker is not routinely performed in the mentioned circumstances. Studies have shown that preoperative CA 125 was significantly high in patients in a higher stage of endometrial cancer. Thus, this study aims to assess the primary role of CA 125 in predicting the stage of endometrial carcinoma, by correlating preoperative serum CA 125 with clinicopathological parameters. Method: The retrospective data of endometrial carcinoma cases consisting of demographic and clinicopathological parameters as well as preoperative serum CA 125 levels were retrieved from Laboratories Information System (LIS) at Hospital Selayang, Selangor, Malaysia, from January 2000 until June 2016. Only 20 cases fulfilled the inclusion and exclusion criteria. Preoperative serum CA 125 was correlated with demographic and clinicopathological parameters, and was analysed using a Kruskal-Wallis test. Results: There was a significant association between elevated serum CA 125 with myometrial and cervical stroma invasion in endometrial carcinoma (p<0.05 )Conclusion: Preoperative serum CA 125 is a useful marker in predicting early stages of endometrial carcinoma, and plays a role in pre-operative cancer staging in endometrial carcinoma.
format Article
author Abu Bakar, Nur Aini
Osman, Malina
Hussin, Huzlinda
spellingShingle Abu Bakar, Nur Aini
Osman, Malina
Hussin, Huzlinda
Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
author_facet Abu Bakar, Nur Aini
Osman, Malina
Hussin, Huzlinda
author_sort Abu Bakar, Nur Aini
title Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
title_short Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
title_full Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
title_fullStr Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
title_full_unstemmed Preoperative serum CA 125 is associated with myometrial and cervical invasion in endometrial carcinoma
title_sort preoperative serum ca 125 is associated with myometrial and cervical invasion in endometrial carcinoma
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/90193/1/12upm.pdf
http://psasir.upm.edu.my/id/eprint/90193/
https://medic.upm.edu.my/upload/dokumen/2020110611191512_2020_0485.pdf
_version_ 1710677199596552192
score 13.211869

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