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Genetic determinants of obesity heterogeneity in type II diabetes

Background: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. Method: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance...

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Main Authors: Khorami, Somayeh Alsadat Hosseini, Abd Mutalib, Mohd Sokhini, Shiraz, Mohammad Feili, Abdullah, Joseph Anthony, Rejali, Zulida, Mohd Ali, Razana, Khaza'ai, Huzwah
Format: Article
Language:English
Published: BioMed Central 2020
Online Access:http://psasir.upm.edu.my/id/eprint/89104/1/OBES.pdf
http://psasir.upm.edu.my/id/eprint/89104/
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00476-6
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spelling my.upm.eprints.891042021-09-21T01:55:49Z http://psasir.upm.edu.my/id/eprint/89104/ Genetic determinants of obesity heterogeneity in type II diabetes Khorami, Somayeh Alsadat Hosseini Abd Mutalib, Mohd Sokhini Shiraz, Mohammad Feili Abdullah, Joseph Anthony Rejali, Zulida Mohd Ali, Razana Khaza'ai, Huzwah Background: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. Method: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism. Result: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. PDK1 gene was expressed at a higher level in non-obese diabetic group compared to obese diabetic and non-obese non-diabetics groups. No statistically significant difference was identified in gene expression pattern of PI3K/AKT pathway between obese non-diabetics and non-obese non-diabetics. Conclusion: The components of PI3K/AKT pathway which is related to the fasting state, showed reduced expression in obese diabetic group due to the chronic over-nutrition which may induced insensitivity and reduced gene expression. The pathogenesis of insulin resistance in the absence of obesity in non-obese diabetic group could be due to disturbance in another pathway related to the non-fasting state like gluconeogenesis. Therefore, the molecular mechanism of insulin signalling in non-obese diabetic individuals is different from obese diabetics which more investigations are required to study insulin signalling pathways in greater depth, in order to assess nutritional factors, contribute to insulin resistance in obese diabetic and non-obese diabetic individuals. BioMed Central 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89104/1/OBES.pdf Khorami, Somayeh Alsadat Hosseini and Abd Mutalib, Mohd Sokhini and Shiraz, Mohammad Feili and Abdullah, Joseph Anthony and Rejali, Zulida and Mohd Ali, Razana and Khaza'ai, Huzwah (2020) Genetic determinants of obesity heterogeneity in type II diabetes. Nutrition & Metabolism, 17. art. no. 55. pp. 1-9. ISSN 1743-7075 https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00476-6 10.1186/s12986-020-00476-6
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. Method: The mRNA expression of PI3K/AKT axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism. Result: In present study, there was no statistically significant difference in gene expression levels of IRS1 and PTEN between groups, whereas PI3K, AKT2 and GLUT4 genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant. PDK1 gene was expressed at a higher level in non-obese diabetic group compared to obese diabetic and non-obese non-diabetics groups. No statistically significant difference was identified in gene expression pattern of PI3K/AKT pathway between obese non-diabetics and non-obese non-diabetics. Conclusion: The components of PI3K/AKT pathway which is related to the fasting state, showed reduced expression in obese diabetic group due to the chronic over-nutrition which may induced insensitivity and reduced gene expression. The pathogenesis of insulin resistance in the absence of obesity in non-obese diabetic group could be due to disturbance in another pathway related to the non-fasting state like gluconeogenesis. Therefore, the molecular mechanism of insulin signalling in non-obese diabetic individuals is different from obese diabetics which more investigations are required to study insulin signalling pathways in greater depth, in order to assess nutritional factors, contribute to insulin resistance in obese diabetic and non-obese diabetic individuals.
format Article
author Khorami, Somayeh Alsadat Hosseini
Abd Mutalib, Mohd Sokhini
Shiraz, Mohammad Feili
Abdullah, Joseph Anthony
Rejali, Zulida
Mohd Ali, Razana
Khaza'ai, Huzwah
spellingShingle Khorami, Somayeh Alsadat Hosseini
Abd Mutalib, Mohd Sokhini
Shiraz, Mohammad Feili
Abdullah, Joseph Anthony
Rejali, Zulida
Mohd Ali, Razana
Khaza'ai, Huzwah
Genetic determinants of obesity heterogeneity in type II diabetes
author_facet Khorami, Somayeh Alsadat Hosseini
Abd Mutalib, Mohd Sokhini
Shiraz, Mohammad Feili
Abdullah, Joseph Anthony
Rejali, Zulida
Mohd Ali, Razana
Khaza'ai, Huzwah
author_sort Khorami, Somayeh Alsadat Hosseini
title Genetic determinants of obesity heterogeneity in type II diabetes
title_short Genetic determinants of obesity heterogeneity in type II diabetes
title_full Genetic determinants of obesity heterogeneity in type II diabetes
title_fullStr Genetic determinants of obesity heterogeneity in type II diabetes
title_full_unstemmed Genetic determinants of obesity heterogeneity in type II diabetes
title_sort genetic determinants of obesity heterogeneity in type ii diabetes
publisher BioMed Central
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/89104/1/OBES.pdf
http://psasir.upm.edu.my/id/eprint/89104/
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00476-6
_version_ 1712286752657375232
score 13.211869

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