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Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system

The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory...

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Main Authors: Mohamed Almbrok, Eissa, Yusof, Nor Azah, Abdullah, Jaafar, Mohd Zawawi, Ruzniza
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Online Access:http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf
http://psasir.upm.edu.my/id/eprint/88769/
https://www.mdpi.com/2227-9040/8/1/11
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spelling my.upm.eprints.887692021-10-06T15:29:16Z http://psasir.upm.edu.my/id/eprint/88769/ Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic treatment in common use in biomedical applications, were also investigated across microporous silicon nitride-modified liquid interface. Thus, some thermodynamic variables for DCF− , such as the standard Gibbs energy of transfer, the standard transfer potential and lipophilicity were estimated. Furthermore, the influence of possible interfering substances (ascorbic acid, sugar, amino acid, urea, and metal ions) on the detection of DCF− was investigated. An electrochemical DCF sensor is investigated using differential pulse voltammetry (DPV) as the quantification technique, a linear range of 8–56 µM and a limit of detection of 1.5 µM was possible due to the miniaturized interfaces formed within silicon nitride. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf Mohamed Almbrok, Eissa and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2020) Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system. Chemosensors, 8 (1). pp. 1-16. ISSN 2227-9040 https://www.mdpi.com/2227-9040/8/1/11 10.3390/chemosensors8010011
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic treatment in common use in biomedical applications, were also investigated across microporous silicon nitride-modified liquid interface. Thus, some thermodynamic variables for DCF− , such as the standard Gibbs energy of transfer, the standard transfer potential and lipophilicity were estimated. Furthermore, the influence of possible interfering substances (ascorbic acid, sugar, amino acid, urea, and metal ions) on the detection of DCF− was investigated. An electrochemical DCF sensor is investigated using differential pulse voltammetry (DPV) as the quantification technique, a linear range of 8–56 µM and a limit of detection of 1.5 µM was possible due to the miniaturized interfaces formed within silicon nitride.
format Article
author Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
spellingShingle Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
author_facet Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
author_sort Mohamed Almbrok, Eissa
title Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
title_short Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
title_full Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
title_fullStr Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
title_full_unstemmed Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
title_sort electrochemical behavior and detection of diclofenac at a microporous si3n4 membrane modified water-1,6-dichlorohexane interface system
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf
http://psasir.upm.edu.my/id/eprint/88769/
https://www.mdpi.com/2227-9040/8/1/11
_version_ 1713201303971168256
score 13.211869

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