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Development of cell penetrating peptides for effective delivery of recombinant factors into target cells

The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has under...

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Main Authors: Vijakumaran, Ubashini, Nordin, Fazlina, Abdul Hamid, Zariyantey, Abdullah, Maha, Tye, Gee Jun
Format: Article
Language:English
Published: Bentham Science 2020
Online Access:http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88430/
https://www.eurekaselect.net/article/106913
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spelling my.upm.eprints.884302021-12-28T06:46:20Z http://psasir.upm.edu.my/id/eprint/88430/ Development of cell penetrating peptides for effective delivery of recombinant factors into target cells Vijakumaran, Ubashini Nordin, Fazlina Abdul Hamid, Zariyantey Abdullah, Maha Tye, Gee Jun The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has undergone 30 years of evolution. To date, CPPs are largely modified to improve its efficacy and to suit the different delivery applications. The modes of CPPs penetration are still an unresolved mystery and requires further investigations to increase its effectiveness and to diversify its use. Despite having huge potential as a biomolecule carrier, CPPs also have some drawbacks. In this review, the natural and synthetic CPPs, the modifications that have been conducted on CPPs to improve its efficacy, its extended applications, modes of penetration and limitation as well as challenges will be discussed. Bentham Science 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf Vijakumaran, Ubashini and Nordin, Fazlina and Abdul Hamid, Zariyantey and Abdullah, Maha and Tye, Gee Jun (2020) Development of cell penetrating peptides for effective delivery of recombinant factors into target cells. Protein and Peptide Letters, 27 (1). pp. 1-10. ISSN 0929-8665; ESSN: 1875-5305 https://www.eurekaselect.net/article/106913 10.2174/0929866527666200525164135
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has undergone 30 years of evolution. To date, CPPs are largely modified to improve its efficacy and to suit the different delivery applications. The modes of CPPs penetration are still an unresolved mystery and requires further investigations to increase its effectiveness and to diversify its use. Despite having huge potential as a biomolecule carrier, CPPs also have some drawbacks. In this review, the natural and synthetic CPPs, the modifications that have been conducted on CPPs to improve its efficacy, its extended applications, modes of penetration and limitation as well as challenges will be discussed.
format Article
author Vijakumaran, Ubashini
Nordin, Fazlina
Abdul Hamid, Zariyantey
Abdullah, Maha
Tye, Gee Jun
spellingShingle Vijakumaran, Ubashini
Nordin, Fazlina
Abdul Hamid, Zariyantey
Abdullah, Maha
Tye, Gee Jun
Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
author_facet Vijakumaran, Ubashini
Nordin, Fazlina
Abdul Hamid, Zariyantey
Abdullah, Maha
Tye, Gee Jun
author_sort Vijakumaran, Ubashini
title Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
title_short Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
title_full Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
title_fullStr Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
title_full_unstemmed Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
title_sort development of cell penetrating peptides for effective delivery of recombinant factors into target cells
publisher Bentham Science
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88430/
https://www.eurekaselect.net/article/106913
_version_ 1724075509290106880
score 13.223943

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