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Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development

Air pollution is a substantial environmental threat to children and acts as acute and chronic disease risk factors alike. Several studies have previously evaluated epigenetic modifications concerning its exposure across various life stages. However, findings on epigenetic modifications as the conseq...

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Main Authors: Suhaimi, Nur Faseeha, Jalaludin, Juliana, Abu Bakar @ Jamaludin, Suhaili
Format: Article
Language:English
Published: Walter de Gruyter 2020
Online Access:http://psasir.upm.edu.my/id/eprint/88360/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88360/
https://www.degruyter.com/document/doi/10.1515/reveh-2020-0065/html
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spelling my.upm.eprints.883602022-11-24T01:48:53Z http://psasir.upm.edu.my/id/eprint/88360/ Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar @ Jamaludin, Suhaili Air pollution is a substantial environmental threat to children and acts as acute and chronic disease risk factors alike. Several studies have previously evaluated epigenetic modifications concerning its exposure across various life stages. However, findings on epigenetic modifications as the consequences of air pollution during childhood are rather minimal. This review evaluated highly relevant studies in the field to analyze the existing literature regarding exposure to air pollution, with a focus on epigenetic alterations during childhood and their connections with respiratory health effects. The search was conducted using readily available electronic databases (PubMed and ScienceDirect) to screen for children's studies on epigenetic mechanisms following either pre- or post-natal exposure to air pollutants. Studies relevant enough and matched the predetermined criteria were chosen to be reviewed. Non-English articles and studies that did not report both air monitoring and epigenetic outcomes in the same article were excluded. The review found that epigenetic changes have been linked with exposure to air pollutants during early life with evidence and reports of how they may deregulate the epigenome balance, thus inducing disease progression in the future. Epigenetic studies evolve as a promising new approach in deciphering the underlying impacts of air pollution on deoxyribonucleic acid (DNA) due to links established between some of these epigenetic mechanisms and illnesses. Walter de Gruyter 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88360/1/ABSTRACT.pdf Suhaimi, Nur Faseeha and Jalaludin, Juliana and Abu Bakar @ Jamaludin, Suhaili (2020) Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development. Reviews on Environmental Health, 36 (1). pp. 77-93. ISSN 0048-7554; ESSN: 2191-0308 https://www.degruyter.com/document/doi/10.1515/reveh-2020-0065/html 10.1515/reveh-2020-0065
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Air pollution is a substantial environmental threat to children and acts as acute and chronic disease risk factors alike. Several studies have previously evaluated epigenetic modifications concerning its exposure across various life stages. However, findings on epigenetic modifications as the consequences of air pollution during childhood are rather minimal. This review evaluated highly relevant studies in the field to analyze the existing literature regarding exposure to air pollution, with a focus on epigenetic alterations during childhood and their connections with respiratory health effects. The search was conducted using readily available electronic databases (PubMed and ScienceDirect) to screen for children's studies on epigenetic mechanisms following either pre- or post-natal exposure to air pollutants. Studies relevant enough and matched the predetermined criteria were chosen to be reviewed. Non-English articles and studies that did not report both air monitoring and epigenetic outcomes in the same article were excluded. The review found that epigenetic changes have been linked with exposure to air pollutants during early life with evidence and reports of how they may deregulate the epigenome balance, thus inducing disease progression in the future. Epigenetic studies evolve as a promising new approach in deciphering the underlying impacts of air pollution on deoxyribonucleic acid (DNA) due to links established between some of these epigenetic mechanisms and illnesses.
format Article
author Suhaimi, Nur Faseeha
Jalaludin, Juliana
Abu Bakar @ Jamaludin, Suhaili
spellingShingle Suhaimi, Nur Faseeha
Jalaludin, Juliana
Abu Bakar @ Jamaludin, Suhaili
Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
author_facet Suhaimi, Nur Faseeha
Jalaludin, Juliana
Abu Bakar @ Jamaludin, Suhaili
author_sort Suhaimi, Nur Faseeha
title Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
title_short Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
title_full Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
title_fullStr Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
title_full_unstemmed Deoxyribonucleic acid (DNA) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
title_sort deoxyribonucleic acid (dna) methylation in children exposed to air pollution: a possible mechanism underlying respiratory health effects development
publisher Walter de Gruyter
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88360/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88360/
https://www.degruyter.com/document/doi/10.1515/reveh-2020-0065/html
_version_ 1751538223653322752
score 13.211869

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