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Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties

Present study prepared curcumin liposomes with high encapsulation efficiency (>70%) using bovine milk and krill phospholipids; and investigated the effects of phospholipids composition on storage stability, in-vitro bioavailability, antioxidative and anti-hyperglycemic properties of the curcumin...

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Main Authors: Wu, Yujie, Mou, Bolin, Song, Shuang, Tan, Chin Ping, Lai, Oi Ming, Shen, Cai, Cheong, Ling Zhi
Format: Article
Language:English
Published: Elsevier 2020
Online Access:http://psasir.upm.edu.my/id/eprint/88324/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88324/
https://www.sciencedirect.com/science/article/pii/S0963996920303264
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spelling my.upm.eprints.883242022-11-24T04:34:35Z http://psasir.upm.edu.my/id/eprint/88324/ Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties Wu, Yujie Mou, Bolin Song, Shuang Tan, Chin Ping Lai, Oi Ming Shen, Cai Cheong, Ling Zhi Present study prepared curcumin liposomes with high encapsulation efficiency (>70%) using bovine milk and krill phospholipids; and investigated the effects of phospholipids composition on storage stability, in-vitro bioavailability, antioxidative and anti-hyperglycemic properties of the curcumin liposomes. Curcumin liposomes prepared from bovine milk phospholipids have smaller particle sizes (163.1 ± 6.42 nm) and greater negative zeta potentials (−26.7 mv) as compared to that prepared from krill phospholipids (particle size: 212.2 ± 4.1 nm, zeta potential: −15.23 mv). In addition, curcumin liposomes from bovine milk phospholipids demonstrated better stability under harsh storage conditions (alkaline conditions, oxygen, high temperature and relative humidity). Nevertheless, curcumin-loaded liposomes prepared from bovine milk phospholipids have inferior bioavailability compared to that prepared from krill phospholipids. No significant differences can be observed in terms of anti-oxidative and anti-hyperglycemic properties of liposomes prepared from both bovine milk and krill phospholipids. Findings from present study will open up new opportunities for development of stable curcumin liposomes with good functional properties (high digestibility, bioavailability and pharmacological effects). Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88324/1/ABSTRACT.pdf Wu, Yujie and Mou, Bolin and Song, Shuang and Tan, Chin Ping and Lai, Oi Ming and Shen, Cai and Cheong, Ling Zhi (2020) Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties. Food Research International, 136. art. no. 109301. pp. 1-11. ISSN 0963-9969 https://www.sciencedirect.com/science/article/pii/S0963996920303264 10.1016/j.foodres.2020.109301
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Present study prepared curcumin liposomes with high encapsulation efficiency (>70%) using bovine milk and krill phospholipids; and investigated the effects of phospholipids composition on storage stability, in-vitro bioavailability, antioxidative and anti-hyperglycemic properties of the curcumin liposomes. Curcumin liposomes prepared from bovine milk phospholipids have smaller particle sizes (163.1 ± 6.42 nm) and greater negative zeta potentials (−26.7 mv) as compared to that prepared from krill phospholipids (particle size: 212.2 ± 4.1 nm, zeta potential: −15.23 mv). In addition, curcumin liposomes from bovine milk phospholipids demonstrated better stability under harsh storage conditions (alkaline conditions, oxygen, high temperature and relative humidity). Nevertheless, curcumin-loaded liposomes prepared from bovine milk phospholipids have inferior bioavailability compared to that prepared from krill phospholipids. No significant differences can be observed in terms of anti-oxidative and anti-hyperglycemic properties of liposomes prepared from both bovine milk and krill phospholipids. Findings from present study will open up new opportunities for development of stable curcumin liposomes with good functional properties (high digestibility, bioavailability and pharmacological effects).
format Article
author Wu, Yujie
Mou, Bolin
Song, Shuang
Tan, Chin Ping
Lai, Oi Ming
Shen, Cai
Cheong, Ling Zhi
spellingShingle Wu, Yujie
Mou, Bolin
Song, Shuang
Tan, Chin Ping
Lai, Oi Ming
Shen, Cai
Cheong, Ling Zhi
Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
author_facet Wu, Yujie
Mou, Bolin
Song, Shuang
Tan, Chin Ping
Lai, Oi Ming
Shen, Cai
Cheong, Ling Zhi
author_sort Wu, Yujie
title Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
title_short Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
title_full Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
title_fullStr Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
title_full_unstemmed Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
title_sort curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties
publisher Elsevier
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/88324/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/88324/
https://www.sciencedirect.com/science/article/pii/S0963996920303264
_version_ 1751538222259765248
score 13.211869

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