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Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system

Pathophysiology of postpartum depression (PPD) has been associated with many factors, such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) improves PPD both in humans and animals. However, little is known with regards to its pharmacology on a PPD-like rat model. Henc...

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Main Authors: Abdul Aziz, Nurul Uyun, Chiroma, Samaila Musa, Mohd Moklas, Mohamad Aris, Adenan, Mohd Ilham, Ismail, Amin, Baharuldin, Mohamad Taufik Hidayat
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2020
Online Access:http://psasir.upm.edu.my/id/eprint/87892/
https://www.mdpi.com/2076-3425/10/10/733
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spelling my.upm.eprints.878922023-01-26T01:57:59Z http://psasir.upm.edu.my/id/eprint/87892/ Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system Abdul Aziz, Nurul Uyun Chiroma, Samaila Musa Mohd Moklas, Mohamad Aris Adenan, Mohd Ilham Ismail, Amin Baharuldin, Mohamad Taufik Hidayat Pathophysiology of postpartum depression (PPD) has been associated with many factors, such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) improves PPD both in humans and animals. However, little is known with regards to its pharmacology on a PPD-like rat model. Hence, the current study aimed at investigating the effects of FO on a PPD-like rat model. Female rats were induced with PPD-like symptoms and then randomly divided into six groups (n = 6) for two experimental protocols. Protocol 1 consisted of PPD-like rats (2 mL distilled water), PPD-like + FO (9 g/kg/d) and PPD-like + Fluoxetine (FLX) (15 mg/kg/d) groups of rats, whereas Protocol 2 consisted of PPD-like rats (2 mL distilled water) + PCPA (p-chlorophenylalanine) 150 mg/kg, PPD-like + FO (9 g/kg/d) + PCPA 150 mg/kg and PPD-like + FLX (15 mg/d) + PCPA 150 mg/kg groups of rats, respectively. All treatments were administered orally for 10 days postpartum, except PCPA, which was given intraperitoneally. Prior to euthanasia, the antidepressant-like effect of the FO was evaluated using the forced swimming test (FST) and open field test (OFT) on day 10 postpartum. Biochemical analysis of serotonin, serotonin metabolite and serotonin turnover from their prefrontal cortex and hippocampus were also measured. The results showed that FO decreased immobility time and increased swimming time significantly, but not climbing time in FST. Further, it also decreased serotonin metabolite and turnover significantly in the hippocampus of the PPD-like rats. In contrast, administration with PCPA reversed all the outcomes. The antidepressant-like effects of FO were found to be similar with that of FLX. Thus, it can be concluded that FO exerts its antidepressant-like effects in PPD-like rats through modulation of serotonergic system. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed Abdul Aziz, Nurul Uyun and Chiroma, Samaila Musa and Mohd Moklas, Mohamad Aris and Adenan, Mohd Ilham and Ismail, Amin and Baharuldin, Mohamad Taufik Hidayat (2020) Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system. Brain Sciences, 10 (10). art. no. 733. pp. 1-13. ISSN 2076-3425 https://www.mdpi.com/2076-3425/10/10/733 10.3390/brainsci10100733
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Pathophysiology of postpartum depression (PPD) has been associated with many factors, such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) improves PPD both in humans and animals. However, little is known with regards to its pharmacology on a PPD-like rat model. Hence, the current study aimed at investigating the effects of FO on a PPD-like rat model. Female rats were induced with PPD-like symptoms and then randomly divided into six groups (n = 6) for two experimental protocols. Protocol 1 consisted of PPD-like rats (2 mL distilled water), PPD-like + FO (9 g/kg/d) and PPD-like + Fluoxetine (FLX) (15 mg/kg/d) groups of rats, whereas Protocol 2 consisted of PPD-like rats (2 mL distilled water) + PCPA (p-chlorophenylalanine) 150 mg/kg, PPD-like + FO (9 g/kg/d) + PCPA 150 mg/kg and PPD-like + FLX (15 mg/d) + PCPA 150 mg/kg groups of rats, respectively. All treatments were administered orally for 10 days postpartum, except PCPA, which was given intraperitoneally. Prior to euthanasia, the antidepressant-like effect of the FO was evaluated using the forced swimming test (FST) and open field test (OFT) on day 10 postpartum. Biochemical analysis of serotonin, serotonin metabolite and serotonin turnover from their prefrontal cortex and hippocampus were also measured. The results showed that FO decreased immobility time and increased swimming time significantly, but not climbing time in FST. Further, it also decreased serotonin metabolite and turnover significantly in the hippocampus of the PPD-like rats. In contrast, administration with PCPA reversed all the outcomes. The antidepressant-like effects of FO were found to be similar with that of FLX. Thus, it can be concluded that FO exerts its antidepressant-like effects in PPD-like rats through modulation of serotonergic system.
format Article
author Abdul Aziz, Nurul Uyun
Chiroma, Samaila Musa
Mohd Moklas, Mohamad Aris
Adenan, Mohd Ilham
Ismail, Amin
Baharuldin, Mohamad Taufik Hidayat
spellingShingle Abdul Aziz, Nurul Uyun
Chiroma, Samaila Musa
Mohd Moklas, Mohamad Aris
Adenan, Mohd Ilham
Ismail, Amin
Baharuldin, Mohamad Taufik Hidayat
Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
author_facet Abdul Aziz, Nurul Uyun
Chiroma, Samaila Musa
Mohd Moklas, Mohamad Aris
Adenan, Mohd Ilham
Ismail, Amin
Baharuldin, Mohamad Taufik Hidayat
author_sort Abdul Aziz, Nurul Uyun
title Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
title_short Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
title_full Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
title_fullStr Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
title_full_unstemmed Antidepressant-like Properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
title_sort antidepressant-like properties of fish oil on postpartum depression-like rats model: involvement of serotonergic system
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/87892/
https://www.mdpi.com/2076-3425/10/10/733
_version_ 1756061498898120704
score 13.211869

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