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1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra

Gynura procumbens and Cleome gynandra are two herbs commonly used in Malaysia to treat various ailments and are also consumed as salads (ulam) and vegetables. The present study aims to evaluate the relationship between the chemical compositions of both herbs and their antioxidant and anti-inflammato...

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Main Authors: Chandradevan, Machap, Simoh, Sanimah, Mediani, Ahmed, Ismail, Intan Safinar, Abas, Faridah
Format: Article
Language:English
Published: Springer 2020
Online Access:http://psasir.upm.edu.my/id/eprint/87564/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/87564/
https://link.springer.com/article/10.1007/s11130-020-00805-3
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spelling my.upm.eprints.875642022-07-06T08:12:54Z http://psasir.upm.edu.my/id/eprint/87564/ 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra Chandradevan, Machap Simoh, Sanimah Mediani, Ahmed Ismail, Intan Safinar Abas, Faridah Gynura procumbens and Cleome gynandra are two herbs commonly used in Malaysia to treat various ailments and are also consumed as salads (ulam) and vegetables. The present study aims to evaluate the relationship between the chemical compositions of both herbs and their antioxidant and anti-inflammatory properties using nuclear magnetic resonance (NMR) metabolomics approach, which is being reported for the first time. Different ethanolic extracts of both herbs were tested for DPPH scavenging and inhibition of nitric oxide (NO) via RAW 264.7 macrophage cell induction. Principal component analysis (PCA) revealed a good separation between the extracts and the corresponding metabolites identified via 1H NMR spectroscopy. The 100% ethanolic extract from both herbs and 20% ethanolic extract of C. gynandra were found to have the best antioxidant and anti-inflammatory activities. Kaempferol, quercetin, caffeoylquinic, dicaffeoylquinic acids, gallic acid, mallic acid, citric acid, phenylalanine, and choline are among the metabolites that contributed to bioactivities. The partial least square (PLS) model for both herbs have an overall acceptable goodness of fit and predictive power, which further strengthens the validity of this study. The present study provides a preliminary reference for the selection of optimum extract and will shed some light on the potential use of G. procumbens and C. gynandra as a phytomedicinal preparation. Springer 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87564/1/ABSTRACT.pdf Chandradevan, Machap and Simoh, Sanimah and Mediani, Ahmed and Ismail, Intan Safinar and Abas, Faridah (2020) 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra. Plant Foods for Human Nutrition, 75 (2). 243 - 251. ISSN 0921-9668; ESSN: 1573-9104 https://link.springer.com/article/10.1007/s11130-020-00805-3 10.1007/s11130-020-00805-3
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Gynura procumbens and Cleome gynandra are two herbs commonly used in Malaysia to treat various ailments and are also consumed as salads (ulam) and vegetables. The present study aims to evaluate the relationship between the chemical compositions of both herbs and their antioxidant and anti-inflammatory properties using nuclear magnetic resonance (NMR) metabolomics approach, which is being reported for the first time. Different ethanolic extracts of both herbs were tested for DPPH scavenging and inhibition of nitric oxide (NO) via RAW 264.7 macrophage cell induction. Principal component analysis (PCA) revealed a good separation between the extracts and the corresponding metabolites identified via 1H NMR spectroscopy. The 100% ethanolic extract from both herbs and 20% ethanolic extract of C. gynandra were found to have the best antioxidant and anti-inflammatory activities. Kaempferol, quercetin, caffeoylquinic, dicaffeoylquinic acids, gallic acid, mallic acid, citric acid, phenylalanine, and choline are among the metabolites that contributed to bioactivities. The partial least square (PLS) model for both herbs have an overall acceptable goodness of fit and predictive power, which further strengthens the validity of this study. The present study provides a preliminary reference for the selection of optimum extract and will shed some light on the potential use of G. procumbens and C. gynandra as a phytomedicinal preparation.
format Article
author Chandradevan, Machap
Simoh, Sanimah
Mediani, Ahmed
Ismail, Intan Safinar
Abas, Faridah
spellingShingle Chandradevan, Machap
Simoh, Sanimah
Mediani, Ahmed
Ismail, Intan Safinar
Abas, Faridah
1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
author_facet Chandradevan, Machap
Simoh, Sanimah
Mediani, Ahmed
Ismail, Intan Safinar
Abas, Faridah
author_sort Chandradevan, Machap
title 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
title_short 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
title_full 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
title_fullStr 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
title_full_unstemmed 1 H NMR-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of Gynura procumbens and Cleome gynandra
title_sort 1 h nmr-based metabolomics approach in investigating the chemical profile, antioxidant and anti-inflammatory activities of gynura procumbens and cleome gynandra
publisher Springer
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/87564/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/87564/
https://link.springer.com/article/10.1007/s11130-020-00805-3
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score 13.211869

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