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Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish

Aphanomyces invadans, an oomycyte fungus most frequently recognized as a causative agent of epizootic ulcerative syndrome (EUS) is a seasonal epidemic pathogen of great importance in wild and farmed fish in both freshwater and estuarine environments. EUS is a complex infectious etiology which leads...

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Main Authors: Kumar, Praveen, Sarkar, Purabi, Raju, Stefi V., V, Manikandan, Guru, Ajay, Arshad, Aziz, Elumalai, Preetham, Arockiaraj, Jesu
Format: Article
Published: Taylor & Francis 2020
Online Access:http://psasir.upm.edu.my/id/eprint/87067/
https://www.tandfonline.com/doi/abs/10.1080/23308249.2020.1753167?journalCode=brfs21
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spelling my.upm.eprints.870672023-09-14T02:42:07Z http://psasir.upm.edu.my/id/eprint/87067/ Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish Kumar, Praveen Sarkar, Purabi Raju, Stefi V. V, Manikandan Guru, Ajay Arshad, Aziz Elumalai, Preetham Arockiaraj, Jesu Aphanomyces invadans, an oomycyte fungus most frequently recognized as a causative agent of epizootic ulcerative syndrome (EUS) is a seasonal epidemic pathogen of great importance in wild and farmed fish in both freshwater and estuarine environments. EUS is a complex infectious etiology which leads to necrosis ulcerative lesions and granulomatous response in fishes. It is a cause of death of approximately 92 species that has been recorded in wild as well as in commercial culture systems worldwide. Several environmental and biological factors are responsible for the growth and establishment of A. invadans, which further attracts secondary pathogens to enter the lesions thus, increasing the severity of the infection. Methods for the proper identification of A. invadans, includes PCR detection and microscopy. However, the pathogenicity of the A. invadans is still unknown. In order to discover new effective treatment to fight the disease, a better understanding of the infection process is necessary. The studies on fungal infection in fishes indicate the immune response pattern in fish against A. invadans that serves as an important key for the development of targeted therapeutics and vaccines to prevent the disease and to maintain EUS free aquaculture systems. The immune mechanisms that respond to stimulation, interaction between the immune system of host species and A. invadans, different factors of A. invadans and its pathogenicity as well as various approaches of treatment has been discussed in this review. Taylor & Francis 2020-05-05 Article PeerReviewed Kumar, Praveen and Sarkar, Purabi and Raju, Stefi V. and V, Manikandan and Guru, Ajay and Arshad, Aziz and Elumalai, Preetham and Arockiaraj, Jesu (2020) Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish. Reviews in Fisheries Science & Aquaculture, 28 (3). 358 - 375. ISSN 2330-8249; ESSN: 2330-8257 https://www.tandfonline.com/doi/abs/10.1080/23308249.2020.1753167?journalCode=brfs21 10.1080/23308249.2020.1753167
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Aphanomyces invadans, an oomycyte fungus most frequently recognized as a causative agent of epizootic ulcerative syndrome (EUS) is a seasonal epidemic pathogen of great importance in wild and farmed fish in both freshwater and estuarine environments. EUS is a complex infectious etiology which leads to necrosis ulcerative lesions and granulomatous response in fishes. It is a cause of death of approximately 92 species that has been recorded in wild as well as in commercial culture systems worldwide. Several environmental and biological factors are responsible for the growth and establishment of A. invadans, which further attracts secondary pathogens to enter the lesions thus, increasing the severity of the infection. Methods for the proper identification of A. invadans, includes PCR detection and microscopy. However, the pathogenicity of the A. invadans is still unknown. In order to discover new effective treatment to fight the disease, a better understanding of the infection process is necessary. The studies on fungal infection in fishes indicate the immune response pattern in fish against A. invadans that serves as an important key for the development of targeted therapeutics and vaccines to prevent the disease and to maintain EUS free aquaculture systems. The immune mechanisms that respond to stimulation, interaction between the immune system of host species and A. invadans, different factors of A. invadans and its pathogenicity as well as various approaches of treatment has been discussed in this review.
format Article
author Kumar, Praveen
Sarkar, Purabi
Raju, Stefi V.
V, Manikandan
Guru, Ajay
Arshad, Aziz
Elumalai, Preetham
Arockiaraj, Jesu
spellingShingle Kumar, Praveen
Sarkar, Purabi
Raju, Stefi V.
V, Manikandan
Guru, Ajay
Arshad, Aziz
Elumalai, Preetham
Arockiaraj, Jesu
Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
author_facet Kumar, Praveen
Sarkar, Purabi
Raju, Stefi V.
V, Manikandan
Guru, Ajay
Arshad, Aziz
Elumalai, Preetham
Arockiaraj, Jesu
author_sort Kumar, Praveen
title Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
title_short Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
title_full Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
title_fullStr Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
title_full_unstemmed Pathogenicity and pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its immunological response in fish
title_sort pathogenicity and pathobiology of epizootic ulcerative syndrome (eus) causing fungus aphanomyces invadans and its immunological response in fish
publisher Taylor & Francis
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/87067/
https://www.tandfonline.com/doi/abs/10.1080/23308249.2020.1753167?journalCode=brfs21
_version_ 1781706666996137984
score 13.211869

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