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Nutrition indicators, physical function, and health-related quality of life in breast cancer patients

Objective: This study aimed to investigate how nutrition indicators and physical function may influence Health-related Quality of Life (HRQoL) of breast cancer patients undergoing treatment. Methods: This was a cross sectional study among a total of 163 breast cancer patients. Series of measurements...

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Main Authors: Ng, Krystal Lu Shin, Chan, Yoke Mun, Mohd Shariff, Zalilah
Format: Article
Language:English
Published: Asian Pacific Organization for Cancer Prevention 2020
Online Access:http://psasir.upm.edu.my/id/eprint/86941/1/Nutrition%20indicators%2C%20physical%20function.pdf
http://psasir.upm.edu.my/id/eprint/86941/
http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:32711419&key=2020.21.7.1939
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spelling my.upm.eprints.869412022-01-07T08:49:45Z http://psasir.upm.edu.my/id/eprint/86941/ Nutrition indicators, physical function, and health-related quality of life in breast cancer patients Ng, Krystal Lu Shin Chan, Yoke Mun Mohd Shariff, Zalilah Objective: This study aimed to investigate how nutrition indicators and physical function may influence Health-related Quality of Life (HRQoL) of breast cancer patients undergoing treatment. Methods: This was a cross sectional study among a total of 163 breast cancer patients. Series of measurements including anthropometry, biochemical, and dietary were employed to assess patients’ nutritional status while physical function was assessed by handgrip strength. HRQoL of patients was determined using European Organization for Research and Treatment of Cancer quality of life questionnaire Core 30 (EORTC-QLQ-C30) version 3.0. Multiple linear regression was used to identify factors associated with HRQoL. Results: Breast cancer patients perceived moderately their overall quality of life (QoL), with the mean global health status (GHS) score of 69.12. Emotional functioning was the poorest functional scale while fatigue was the most distressing symptom presented by the patients. Approximately 20% of patients had low corrected arm muscle area while more than half had low hemoglobin level. More than 90% of patients did not meet the overall dietary recommendation and had poor handgrip strength. Mid-upper arm circumference (MUAC) was associated with GHS (β: 0.906; 95% CI: 0.22, 1.56) and cognitive functioning (β: -1.543; 95% CI: -3.07, -0.01). Handgrip strength was positively associated with most of HRQoL outcomes. Conclusions: Breast cancer patients reported overall good nutritional status and moderate QoL during treatment. Being well-nourished improved HRQoL and handgrip strength could be a potential proxy for functional outcomes as well as overall QoL. Asian Pacific Organization for Cancer Prevention 2020-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86941/1/Nutrition%20indicators%2C%20physical%20function.pdf Ng, Krystal Lu Shin and Chan, Yoke Mun and Mohd Shariff, Zalilah (2020) Nutrition indicators, physical function, and health-related quality of life in breast cancer patients. Asian Pacific Journal of Cancer Prevention, 21 (7). 1939 - 1950. ISSN 1513-7368 http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:32711419&key=2020.21.7.1939 10.31557/APJCP.2020.21.7.1939
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objective: This study aimed to investigate how nutrition indicators and physical function may influence Health-related Quality of Life (HRQoL) of breast cancer patients undergoing treatment. Methods: This was a cross sectional study among a total of 163 breast cancer patients. Series of measurements including anthropometry, biochemical, and dietary were employed to assess patients’ nutritional status while physical function was assessed by handgrip strength. HRQoL of patients was determined using European Organization for Research and Treatment of Cancer quality of life questionnaire Core 30 (EORTC-QLQ-C30) version 3.0. Multiple linear regression was used to identify factors associated with HRQoL. Results: Breast cancer patients perceived moderately their overall quality of life (QoL), with the mean global health status (GHS) score of 69.12. Emotional functioning was the poorest functional scale while fatigue was the most distressing symptom presented by the patients. Approximately 20% of patients had low corrected arm muscle area while more than half had low hemoglobin level. More than 90% of patients did not meet the overall dietary recommendation and had poor handgrip strength. Mid-upper arm circumference (MUAC) was associated with GHS (β: 0.906; 95% CI: 0.22, 1.56) and cognitive functioning (β: -1.543; 95% CI: -3.07, -0.01). Handgrip strength was positively associated with most of HRQoL outcomes. Conclusions: Breast cancer patients reported overall good nutritional status and moderate QoL during treatment. Being well-nourished improved HRQoL and handgrip strength could be a potential proxy for functional outcomes as well as overall QoL.
format Article
author Ng, Krystal Lu Shin
Chan, Yoke Mun
Mohd Shariff, Zalilah
spellingShingle Ng, Krystal Lu Shin
Chan, Yoke Mun
Mohd Shariff, Zalilah
Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
author_facet Ng, Krystal Lu Shin
Chan, Yoke Mun
Mohd Shariff, Zalilah
author_sort Ng, Krystal Lu Shin
title Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
title_short Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
title_full Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
title_fullStr Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
title_full_unstemmed Nutrition indicators, physical function, and health-related quality of life in breast cancer patients
title_sort nutrition indicators, physical function, and health-related quality of life in breast cancer patients
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/86941/1/Nutrition%20indicators%2C%20physical%20function.pdf
http://psasir.upm.edu.my/id/eprint/86941/
http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:32711419&key=2020.21.7.1939
_version_ 1724075481526960128
score 13.211869

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