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Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress

Identifying a non-enzymatic sensor electrocatalyst for the accurate determination of biomolecules is a paramount task. The weird morphology of the nanomaterial may exhibit the remarkable activity to enhance the sensitivity of the electrode, and hence, tuning the shape of the nanomaterials is one of...

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Main Authors: N. S. K., Gowthaman, P., Arul, Hong, Ngee Lim, S. Abraham, John
Format: Article
Language:English
Published: American Chemical Society 2020
Online Access:http://psasir.upm.edu.my/id/eprint/86886/1/Negative%20potential%20induced%20growth%20of%20surfactant.pdf
http://psasir.upm.edu.my/id/eprint/86886/
https://pubs.acs.org/doi/abs/10.1021/acssuschemeng.9b05648
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spelling my.upm.eprints.868862021-12-30T07:30:07Z http://psasir.upm.edu.my/id/eprint/86886/ Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress N. S. K., Gowthaman P., Arul Hong, Ngee Lim S. Abraham, John Identifying a non-enzymatic sensor electrocatalyst for the accurate determination of biomolecules is a paramount task. The weird morphology of the nanomaterial may exhibit the remarkable activity to enhance the sensitivity of the electrode, and hence, tuning the shape of the nanomaterials is one of the important criteria for electrochemical sensors. Thus, this study sought to fabricate a non-enzymatic sensor with different CuO morphologies by an eco-friendly and facile approach. Different surfactant-free CuO nanostructures were fabricated on the highly conductive flexible aluminum–carbide substrate for the electrochemical assessment of glucose and H2O2 in human fluids. The CuO nanostructures were initially electrodeposited at −0.1, −0.3, −0.5, and −0.7 V and then calcined in air at 120 °C for 2 h. Different CuO nanostructures with a polygonal and cactus-like morphology were observed in scanning electron microscopic images. The as-fabricated electrodes were also characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy analysis. Texture coefficients (TC) of different CuO nanostructures were calculated from XRD analysis, and the CuO nanostructures grown at −0.5 V exhibited the highest TC with their texture along the (022) plane. The electrodes grown with different CuO nanostructures exhibited shape-dependent electrocatalytic activity against glucose and H2O2, and the cactus-like CuO nanostructures grown at −0.5 V showed superior electrochemical behavior compared to that of the other nanostructures by showing superior sensitivities of 3892.6 and 2015.7 μA mM–1 cm–2, respectively, against glucose and H2O2. In addition, the sensor grown with a cactus-like CuO nanostructure exhibited high selectivity, storage capability, and good practicability. This sensor proved to be practical by determining glucose and H2O2 levels in human fluids. It is believed that the proposed electrochemical sensor will have a strong impact in the dual in-line sensing of biomarkers in both biological and clinical fields in the near future. American Chemical Society 2020-02-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86886/1/Negative%20potential%20induced%20growth%20of%20surfactant.pdf N. S. K., Gowthaman and P., Arul and Hong, Ngee Lim and S. Abraham, John (2020) Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress. ACS Sustainable Chemistry & Engineering, 8 (7). 2640 - 2651. ISSN 2168-0485 https://pubs.acs.org/doi/abs/10.1021/acssuschemeng.9b05648 10.1021/acssuschemeng.9b05648
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Identifying a non-enzymatic sensor electrocatalyst for the accurate determination of biomolecules is a paramount task. The weird morphology of the nanomaterial may exhibit the remarkable activity to enhance the sensitivity of the electrode, and hence, tuning the shape of the nanomaterials is one of the important criteria for electrochemical sensors. Thus, this study sought to fabricate a non-enzymatic sensor with different CuO morphologies by an eco-friendly and facile approach. Different surfactant-free CuO nanostructures were fabricated on the highly conductive flexible aluminum–carbide substrate for the electrochemical assessment of glucose and H2O2 in human fluids. The CuO nanostructures were initially electrodeposited at −0.1, −0.3, −0.5, and −0.7 V and then calcined in air at 120 °C for 2 h. Different CuO nanostructures with a polygonal and cactus-like morphology were observed in scanning electron microscopic images. The as-fabricated electrodes were also characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy analysis. Texture coefficients (TC) of different CuO nanostructures were calculated from XRD analysis, and the CuO nanostructures grown at −0.5 V exhibited the highest TC with their texture along the (022) plane. The electrodes grown with different CuO nanostructures exhibited shape-dependent electrocatalytic activity against glucose and H2O2, and the cactus-like CuO nanostructures grown at −0.5 V showed superior electrochemical behavior compared to that of the other nanostructures by showing superior sensitivities of 3892.6 and 2015.7 μA mM–1 cm–2, respectively, against glucose and H2O2. In addition, the sensor grown with a cactus-like CuO nanostructure exhibited high selectivity, storage capability, and good practicability. This sensor proved to be practical by determining glucose and H2O2 levels in human fluids. It is believed that the proposed electrochemical sensor will have a strong impact in the dual in-line sensing of biomarkers in both biological and clinical fields in the near future.
format Article
author N. S. K., Gowthaman
P., Arul
Hong, Ngee Lim
S. Abraham, John
spellingShingle N. S. K., Gowthaman
P., Arul
Hong, Ngee Lim
S. Abraham, John
Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
author_facet N. S. K., Gowthaman
P., Arul
Hong, Ngee Lim
S. Abraham, John
author_sort N. S. K., Gowthaman
title Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
title_short Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
title_full Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
title_fullStr Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
title_full_unstemmed Negative potential induced growth of surfactant-free CuO nanostructures on Al-C substrate: A dual in-line sensor for biomarkers of diabetes and oxidative stress
title_sort negative potential induced growth of surfactant-free cuo nanostructures on al-c substrate: a dual in-line sensor for biomarkers of diabetes and oxidative stress
publisher American Chemical Society
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/86886/1/Negative%20potential%20induced%20growth%20of%20surfactant.pdf
http://psasir.upm.edu.my/id/eprint/86886/
https://pubs.acs.org/doi/abs/10.1021/acssuschemeng.9b05648
_version_ 1724075474213142528
score 13.211869

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