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Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study

Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels d...

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Main Authors: Woon, Fui Chee, Chin, Yit Siew, Ismail, Intan Hakimah, Abdul Latiff, Amir Hamzah, Batterham, Marijka, Chan, Yoke Mun
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Online Access:http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf
http://psasir.upm.edu.my/id/eprint/86655/
https://www.mdpi.com/2072-6643/12/8/2418
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spelling my.upm.eprints.866552021-11-05T02:13:58Z http://psasir.upm.edu.my/id/eprint/86655/ Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study Woon, Fui Chee Chin, Yit Siew Ismail, Intan Hakimah Abdul Latiff, Amir Hamzah Batterham, Marijka Chan, Yoke Mun Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life. Multidisciplinary Digital Publishing Institute 2020-08-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf Woon, Fui Chee and Chin, Yit Siew and Ismail, Intan Hakimah and Abdul Latiff, Amir Hamzah and Batterham, Marijka and Chan, Yoke Mun (2020) Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study. Nutrients, 12 (8). art. no. 2418. pp. 1-12. ISSN 2072-6643 https://www.mdpi.com/2072-6643/12/8/2418 10.3390/nu12082418
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine the associations between maternal Vitamin D levels during late pregnancy and allergic diseases in Malaysian infants during the first year of life. Serum 25(OH)D concentrations of 380 pregnant women in the third trimester were measured using a chemiluminescent immunoassay. Children’s allergic outcomes were assessed at 3, 6, and 12 months based on parental reports. Specific IgE antibodies against food and inhalant allergens were measured in infants at 12 months of age. A total of 43.2% pregnant women were Vitamin D deficient (<30 nmol/L) and 56.8% were nondeficient (≥30 nmol/L). A total of 27.6% of the infants had eczema, 6.1% had wheeze, 27.4% had food sensitization, 10.8% had inhalant allergen sensitization, and 3.8% had IgE-mediated food allergy during the first year of life. Compared with the nondeficient group, maternal Vitamin D deficiency in late pregnancy was not associated with any allergic outcomes after adjustment for potential confounding factors. In conclusion, the present study does not support an association between maternal Vitamin D levels in late pregnancy and allergic outcomes during the first year of life.
format Article
author Woon, Fui Chee
Chin, Yit Siew
Ismail, Intan Hakimah
Abdul Latiff, Amir Hamzah
Batterham, Marijka
Chan, Yoke Mun
spellingShingle Woon, Fui Chee
Chin, Yit Siew
Ismail, Intan Hakimah
Abdul Latiff, Amir Hamzah
Batterham, Marijka
Chan, Yoke Mun
Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
author_facet Woon, Fui Chee
Chin, Yit Siew
Ismail, Intan Hakimah
Abdul Latiff, Amir Hamzah
Batterham, Marijka
Chan, Yoke Mun
author_sort Woon, Fui Chee
title Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
title_short Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
title_full Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
title_fullStr Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
title_full_unstemmed Maternal Vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
title_sort maternal vitamin d levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life—a birth cohort study
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/86655/1/Maternal%20Vitamin%20D%20.pdf
http://psasir.upm.edu.my/id/eprint/86655/
https://www.mdpi.com/2072-6643/12/8/2418
_version_ 1717095378856181760
score 13.211869

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