Staff View: Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS

Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS

Background: β-thalassemia is a genetic disease that causes abnormal production of red blood cells (ineffective erythropoiesis, IE). IE is a condition known to change bone marrow composition. Purpose: To evaluate the effect of IE on the marrow fat content and fat unsaturation levels in the proximal f...

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Main Authors:	Ismail, Umi Nabilah, Azlan, Che Ahmad, Khairullah, Shasha, Azman, Raja Rizal, Omar, Nur Farhayu, Md Shah, Mohammad Nazri, Yeong, Chai Hong, Jackson, Nicholas, Ng, Kwan Hoong
Format:	Article
Language:	English
Published:	Wiley 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/86649/1/Marrow%20fat%20content%20and%20composition%20in%20%CE%B2%E2%80%90Thalassemia.pdf http://psasir.upm.edu.my/id/eprint/86649/ https://pubmed.ncbi.nlm.nih.gov/33237616/
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spelling	my.upm.eprints.866492021-10-17T21:46:32Z http://psasir.upm.edu.my/id/eprint/86649/ Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Yeong, Chai Hong Jackson, Nicholas Ng, Kwan Hoong Background: β-thalassemia is a genetic disease that causes abnormal production of red blood cells (ineffective erythropoiesis, IE). IE is a condition known to change bone marrow composition. Purpose: To evaluate the effect of IE on the marrow fat content and fat unsaturation levels in the proximal femur using 1 H-MRS. Study Type: Prospective. Subjects: Twenty-three subjects were included in this study, seven control and 16 β-thalassemia subjects. Field Strength/Sequence: 3.0T; stimulated echo acquisition Mode (STEAM); magnetic resonance spectroscopy (MRS) sequence. Assessment: Multiecho MRS scans were performed in four regions of the proximal left femur of each subject, that is, diaphysis, femoral neck, femoral head, and greater trochanter. The examined regions were grouped into red (diaphysis and femoral neck) and yellow marrow regions (femoral head and greater trochanter). Statistical Tests: The Jonckheere–Terpstra test was used to evaluate the impact of increasing disease severity on bone marrow fat fraction (BMFF), marrow conversion index, and fat unsaturation index (UI). Pairwise comparison analysis was performed when a significant trend (P < 0.05) was found. K-means clustering analysis was used to examine the clusters observed when BMFF in the red and yellow regions were studied (diaphysis against greater trochanter). Results: BMFF showed a significant decreasing trend with increasing disease severity in both red (TJT = 109.00, z = –4.414, P < 0.05) and yellow marrow regions (TJT = 108.00, z = –4.438, P < 0.05). The opposite trend was observed in UI in both bone marrow regions (red marrow: TJT = 180.5, z = 3.515, P < 0.05; yellow marrow: TJT = 155.0, z = 2.282, P = 0.05). Three distinct forms of marrow adipogenesis were found when plotting BMFF diaphysis against BMFF greater trochanter: 1) normal (centroid: 80.4%, 66.6%), 2) partial disruption (centroid: 51.1%, 16.6%), and 3) total disruption (centroid: 2.6%, 1.6%). Data Conclusion: β-thalassemia is associated with decreased marrow fat, and increased marrow fat unsaturation level. Level of Evidence: 2 Technical Efficacy Stage: 3. Wiley 2021-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86649/1/Marrow%20fat%20content%20and%20composition%20in%20%CE%B2%E2%80%90Thalassemia.pdf Ismail, Umi Nabilah and Azlan, Che Ahmad and Khairullah, Shasha and Azman, Raja Rizal and Omar, Nur Farhayu and Md Shah, Mohammad Nazri and Yeong, Chai Hong and Jackson, Nicholas and Ng, Kwan Hoong (2021) Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS. Journal of Magnetic Resonance Imaging, 53 (1). 190 - 198. ISSN 1053-1807; ESSN: 1522-2586 https://pubmed.ncbi.nlm.nih.gov/33237616/ 10.1002/jmri.27294
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Background: β-thalassemia is a genetic disease that causes abnormal production of red blood cells (ineffective erythropoiesis, IE). IE is a condition known to change bone marrow composition. Purpose: To evaluate the effect of IE on the marrow fat content and fat unsaturation levels in the proximal femur using 1 H-MRS. Study Type: Prospective. Subjects: Twenty-three subjects were included in this study, seven control and 16 β-thalassemia subjects. Field Strength/Sequence: 3.0T; stimulated echo acquisition Mode (STEAM); magnetic resonance spectroscopy (MRS) sequence. Assessment: Multiecho MRS scans were performed in four regions of the proximal left femur of each subject, that is, diaphysis, femoral neck, femoral head, and greater trochanter. The examined regions were grouped into red (diaphysis and femoral neck) and yellow marrow regions (femoral head and greater trochanter). Statistical Tests: The Jonckheere–Terpstra test was used to evaluate the impact of increasing disease severity on bone marrow fat fraction (BMFF), marrow conversion index, and fat unsaturation index (UI). Pairwise comparison analysis was performed when a significant trend (P < 0.05) was found. K-means clustering analysis was used to examine the clusters observed when BMFF in the red and yellow regions were studied (diaphysis against greater trochanter). Results: BMFF showed a significant decreasing trend with increasing disease severity in both red (TJT = 109.00, z = –4.414, P < 0.05) and yellow marrow regions (TJT = 108.00, z = –4.438, P < 0.05). The opposite trend was observed in UI in both bone marrow regions (red marrow: TJT = 180.5, z = 3.515, P < 0.05; yellow marrow: TJT = 155.0, z = 2.282, P = 0.05). Three distinct forms of marrow adipogenesis were found when plotting BMFF diaphysis against BMFF greater trochanter: 1) normal (centroid: 80.4%, 66.6%), 2) partial disruption (centroid: 51.1%, 16.6%), and 3) total disruption (centroid: 2.6%, 1.6%). Data Conclusion: β-thalassemia is associated with decreased marrow fat, and increased marrow fat unsaturation level. Level of Evidence: 2 Technical Efficacy Stage: 3.
format	Article
author	Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Yeong, Chai Hong Jackson, Nicholas Ng, Kwan Hoong
spellingShingle	Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Yeong, Chai Hong Jackson, Nicholas Ng, Kwan Hoong Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
author_facet	Ismail, Umi Nabilah Azlan, Che Ahmad Khairullah, Shasha Azman, Raja Rizal Omar, Nur Farhayu Md Shah, Mohammad Nazri Yeong, Chai Hong Jackson, Nicholas Ng, Kwan Hoong
author_sort	Ismail, Umi Nabilah
title	Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
title_short	Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
title_full	Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
title_fullStr	Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
title_full_unstemmed	Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS
title_sort	marrow fat content and composition in β‐thalassemia: a study using 1h‐mrs
publisher	Wiley
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/86649/1/Marrow%20fat%20content%20and%20composition%20in%20%CE%B2%E2%80%90Thalassemia.pdf http://psasir.upm.edu.my/id/eprint/86649/ https://pubmed.ncbi.nlm.nih.gov/33237616/
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score	13.211869

Marrow fat content and composition in β‐Thalassemia: a study using 1H‐MRS

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