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Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)

Following its capture in March 2014, an adult female Sumatran rhinoceros frequently showed profuse vaginal bleeding. An ultrasonography suggested the presence of multiple reproductive lesions, including two uterine masses which were suspected to be leiomyomas. Soon after, an open pyometra was confir...

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Main Authors: Salleh, Annas, Zainuddin, Zainal Zahari, Mohamed Tarmizi, Mohamed Reza, Yap, Keng Chee, Saad, Mohd Zamri
Format: Article
Published: Taylor & Francis 2020
Online Access:http://psasir.upm.edu.my/id/eprint/86411/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594725/
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spelling my.upm.eprints.864112022-10-19T01:40:31Z http://psasir.upm.edu.my/id/eprint/86411/ Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis) Salleh, Annas Zainuddin, Zainal Zahari Mohamed Tarmizi, Mohamed Reza Yap, Keng Chee Saad, Mohd Zamri Following its capture in March 2014, an adult female Sumatran rhinoceros frequently showed profuse vaginal bleeding. An ultrasonography suggested the presence of multiple reproductive lesions, including two uterine masses which were suspected to be leiomyomas. Soon after, an open pyometra was confirmed. Later in November 2019, the patient died and necropsy confirmed the presence of two uterine masses; one was located at the cervico-uterine junction and another in the uterine body, with pyometra, and cystic endometrial hyerplasia. Based on histological, special stains, and immunohistochemical examination, it was shown that one of the masses was composed of large, ovoid and polyhedral neoplastic mesenchymal cells with eosinophilic cytoplasm and a few binucleated cells surrounded by collagen fibres. It was tested positive for SMA and vimentin, while negative for desmin, cytokeratin AE1/AE3, EMA, CD34, and S100. The other mass was composed of mesenchymal cells undergoing myxoid degeneration as evidenced by the presence of glycosaminoglycan-rich matrix. It was tested positive for SMA, vimentin, partially positive for desmin, and negative for the other markers. With the aid of human medical nomenclature, these masses were diagnosed as epithelioid leiomyoma and myxoid leiomyoma, respectively. This report provides a clinical presentation, and histologic descriptions of the two variants of leiomyomas that have not been reported in veterinary medicine. Taylor & Francis 2020 Article PeerReviewed Salleh, Annas and Zainuddin, Zainal Zahari and Mohamed Tarmizi, Mohamed Reza and Yap, Keng Chee and Saad, Mohd Zamri (2020) Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis). 250 - 257. ISSN 0165-2176; ESSN: 1875-5941 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594725/ 10.1080/01652176.2020.1836431
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Following its capture in March 2014, an adult female Sumatran rhinoceros frequently showed profuse vaginal bleeding. An ultrasonography suggested the presence of multiple reproductive lesions, including two uterine masses which were suspected to be leiomyomas. Soon after, an open pyometra was confirmed. Later in November 2019, the patient died and necropsy confirmed the presence of two uterine masses; one was located at the cervico-uterine junction and another in the uterine body, with pyometra, and cystic endometrial hyerplasia. Based on histological, special stains, and immunohistochemical examination, it was shown that one of the masses was composed of large, ovoid and polyhedral neoplastic mesenchymal cells with eosinophilic cytoplasm and a few binucleated cells surrounded by collagen fibres. It was tested positive for SMA and vimentin, while negative for desmin, cytokeratin AE1/AE3, EMA, CD34, and S100. The other mass was composed of mesenchymal cells undergoing myxoid degeneration as evidenced by the presence of glycosaminoglycan-rich matrix. It was tested positive for SMA, vimentin, partially positive for desmin, and negative for the other markers. With the aid of human medical nomenclature, these masses were diagnosed as epithelioid leiomyoma and myxoid leiomyoma, respectively. This report provides a clinical presentation, and histologic descriptions of the two variants of leiomyomas that have not been reported in veterinary medicine.
format Article
author Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Keng Chee
Saad, Mohd Zamri
spellingShingle Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Keng Chee
Saad, Mohd Zamri
Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
author_facet Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Keng Chee
Saad, Mohd Zamri
author_sort Salleh, Annas
title Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
title_short Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
title_full Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
title_fullStr Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
title_full_unstemmed Two variants of uterine leiomyoma in Malaysia's last Sumatran rhinoceros (Dicerorhinus sumatrensis)
title_sort two variants of uterine leiomyoma in malaysia's last sumatran rhinoceros (dicerorhinus sumatrensis)
publisher Taylor & Francis
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/86411/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594725/
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