Cover Image

Determination of antifungal activity of plant extracts

Fungal disease is considered as one of the current emerging diseases since many fungal pathogens such as Candida albicans can undergo mutation rapidly and resistant to common antifungal agents. Plants are expected to contain natural antimicrobial compounds such as alkaloids, flavonoids, and phenolic...

Full description

Saved in:
Bibliographic Details
Main Author: Lau, Ee Hong
Format: Project Paper Report
Language:English
Published: 2015
Online Access:http://psasir.upm.edu.my/id/eprint/85116/1/FBSB%202015%20105%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/85116/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.85116
record_format eprints
spelling my.upm.eprints.851162021-12-09T03:16:40Z http://psasir.upm.edu.my/id/eprint/85116/ Determination of antifungal activity of plant extracts Lau, Ee Hong Fungal disease is considered as one of the current emerging diseases since many fungal pathogens such as Candida albicans can undergo mutation rapidly and resistant to common antifungal agents. Plants are expected to contain natural antimicrobial compounds such as alkaloids, flavonoids, and phenolic compounds to protect themselves from microbial diseases. Thus, plants are one of the potential sources to obtain new antifungal agents. The aim of this study was to determine the antifungal activity of 12 species of plants in Malaysia against Aspergillus niger and Candida albicans. Disc diffusion method was used in this study to assess the antifungal properties of plants and measurement of minimum inhibitory concentration (MIC) was done by resazurin-based microtiter dilution assay. The results showed that all tested plant extracts had no activity against A. niger and only 3 extracts (Coleus amboinicus, Ipomoea aquatica, and Premna cordifolia) exhibited weak antifungal activity against C. albicans. Among them, I. aquatica showed best antifungal activity against C. albicans with 10 mm clearing zone at concentration of 25 mg/mL. The MIC of C. amboinicus, I. aquatica and P. cordifolia were 3.125, 1.56, and 3.125 mg/mL respectively. This study showed that none of the tested plants is a potential source of new antifungal agents since all of them failed to inhibit the growth of tested fungi effectively. 2015-06 Project Paper Report NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/85116/1/FBSB%202015%20105%20-%20IR.pdf Lau, Ee Hong (2015) Determination of antifungal activity of plant extracts. [Project Paper Report]
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Fungal disease is considered as one of the current emerging diseases since many fungal pathogens such as Candida albicans can undergo mutation rapidly and resistant to common antifungal agents. Plants are expected to contain natural antimicrobial compounds such as alkaloids, flavonoids, and phenolic compounds to protect themselves from microbial diseases. Thus, plants are one of the potential sources to obtain new antifungal agents. The aim of this study was to determine the antifungal activity of 12 species of plants in Malaysia against Aspergillus niger and Candida albicans. Disc diffusion method was used in this study to assess the antifungal properties of plants and measurement of minimum inhibitory concentration (MIC) was done by resazurin-based microtiter dilution assay. The results showed that all tested plant extracts had no activity against A. niger and only 3 extracts (Coleus amboinicus, Ipomoea aquatica, and Premna cordifolia) exhibited weak antifungal activity against C. albicans. Among them, I. aquatica showed best antifungal activity against C. albicans with 10 mm clearing zone at concentration of 25 mg/mL. The MIC of C. amboinicus, I. aquatica and P. cordifolia were 3.125, 1.56, and 3.125 mg/mL respectively. This study showed that none of the tested plants is a potential source of new antifungal agents since all of them failed to inhibit the growth of tested fungi effectively.
format Project Paper Report
author Lau, Ee Hong
spellingShingle Lau, Ee Hong
Determination of antifungal activity of plant extracts
author_facet Lau, Ee Hong
author_sort Lau, Ee Hong
title Determination of antifungal activity of plant extracts
title_short Determination of antifungal activity of plant extracts
title_full Determination of antifungal activity of plant extracts
title_fullStr Determination of antifungal activity of plant extracts
title_full_unstemmed Determination of antifungal activity of plant extracts
title_sort determination of antifungal activity of plant extracts
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/85116/1/FBSB%202015%20105%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/85116/
_version_ 1720438483256868864
score 13.211869

Similar Items