Cover Image

Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells

Cancer is a major health problem and causes significant morbidity and mortality. Bone cancer is an uncommon cancer that begins in a bone and it mostly occurs in children and teens. Cancer treatment by conventional medicine, surgery, chemotherapy and radiotherapy have been the primary approaches, but...

Full description

Saved in:
Bibliographic Details
Main Author: Choo, Jie Ying
Format: Project Paper Report
Language:English
Published: 2015
Online Access:http://psasir.upm.edu.my/id/eprint/85110/1/FBSB%202015%2099%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/85110/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.85110
record_format eprints
spelling my.upm.eprints.851102021-12-27T04:08:32Z http://psasir.upm.edu.my/id/eprint/85110/ Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells Choo, Jie Ying Cancer is a major health problem and causes significant morbidity and mortality. Bone cancer is an uncommon cancer that begins in a bone and it mostly occurs in children and teens. Cancer treatment by conventional medicine, surgery, chemotherapy and radiotherapy have been the primary approaches, but they are not always effective. The use of complementary alternative medicine (CAM) has grown rapidly in popularity both among the general population and among cancer patients. Therefore, we hypothesize that plant extracts exert antiproliferative effect on cancer cells. The objective of this study is to evaluate the antiproliferation effects on cancer cells using selected plant extracts. Results showed that Psidium guajava extracts showed cytotoxic effect on human Saos-2 cells, however, Morinda citrifolia extracts do not exhibit any inhibition on Saos-2 cells. P.guajava leaves have more cytotoxic effects than M.citrifolia leaves. Further study of P. guajava can be applied to determine the optimal concentration of a leaf extract for cancer treatment, while, M. citrifolia can be recommended for further study on wound healing effects. 2015 Project Paper Report NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/85110/1/FBSB%202015%2099%20-%20IR.pdf Choo, Jie Ying (2015) Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells. [Project Paper Report]
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Cancer is a major health problem and causes significant morbidity and mortality. Bone cancer is an uncommon cancer that begins in a bone and it mostly occurs in children and teens. Cancer treatment by conventional medicine, surgery, chemotherapy and radiotherapy have been the primary approaches, but they are not always effective. The use of complementary alternative medicine (CAM) has grown rapidly in popularity both among the general population and among cancer patients. Therefore, we hypothesize that plant extracts exert antiproliferative effect on cancer cells. The objective of this study is to evaluate the antiproliferation effects on cancer cells using selected plant extracts. Results showed that Psidium guajava extracts showed cytotoxic effect on human Saos-2 cells, however, Morinda citrifolia extracts do not exhibit any inhibition on Saos-2 cells. P.guajava leaves have more cytotoxic effects than M.citrifolia leaves. Further study of P. guajava can be applied to determine the optimal concentration of a leaf extract for cancer treatment, while, M. citrifolia can be recommended for further study on wound healing effects.
format Project Paper Report
author Choo, Jie Ying
spellingShingle Choo, Jie Ying
Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
author_facet Choo, Jie Ying
author_sort Choo, Jie Ying
title Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
title_short Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
title_full Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
title_fullStr Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
title_full_unstemmed Cytotoxic effects of methanolic extracts of Psidium guajava and Morinda citrifolia on human osteosarcoma SAOS-2 cells
title_sort cytotoxic effects of methanolic extracts of psidium guajava and morinda citrifolia on human osteosarcoma saos-2 cells
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/85110/1/FBSB%202015%2099%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/85110/
_version_ 1724075459042344960
score 13.211869

Similar Items