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The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice

For decades, chlorhexidine has been used in the medical field for its disinfectant properties. Yet, chlorhexidine is found to illicit hypersensitivity reactions in human, but whether it can produce the same reaction in animals remain unclear. In this study, we investigate the effects of C5aR antagon...

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Main Author: Siong, Jing Jing
Format: Project Paper Report
Language:English
Published: 2015
Online Access:http://psasir.upm.edu.my/id/eprint/83500/1/FPV%202015%2071%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/83500/
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spelling my.upm.eprints.835002020-09-29T04:23:55Z http://psasir.upm.edu.my/id/eprint/83500/ The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice Siong, Jing Jing For decades, chlorhexidine has been used in the medical field for its disinfectant properties. Yet, chlorhexidine is found to illicit hypersensitivity reactions in human, but whether it can produce the same reaction in animals remain unclear. In this study, we investigate the effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice. Mice were randomly divided into four groups for chlorhexidine induced contact dermatitis and given treatments of Dexamethasone, Histamil, complement component C5a receptor antagonist PMX205 and saline. Blood samples were taken for haematology while skin samples were taken for histopathology analysis. The viability of serum IgE for allergy reaction is detected by ELISA technique. Results obtained from the study indicate that treatment of chlorhexidine-induced contact dermatitis by C5aR antagonist has managed to reduce the severity of the lesions similar to anti-histamine and corticosteroid treatment based on the gross skin lesion scoring and histopathological evaluation. The blood parameters did not showed any significant changes compared to normal. As a summary, C5aR antagonism provides an alternative towards the treatment of chlorhexidine-induced contact dermatitis. 2015-03 Project Paper Report NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/83500/1/FPV%202015%2071%20-%20IR.pdf Siong, Jing Jing (2015) The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice. [Project Paper Report]
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description For decades, chlorhexidine has been used in the medical field for its disinfectant properties. Yet, chlorhexidine is found to illicit hypersensitivity reactions in human, but whether it can produce the same reaction in animals remain unclear. In this study, we investigate the effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice. Mice were randomly divided into four groups for chlorhexidine induced contact dermatitis and given treatments of Dexamethasone, Histamil, complement component C5a receptor antagonist PMX205 and saline. Blood samples were taken for haematology while skin samples were taken for histopathology analysis. The viability of serum IgE for allergy reaction is detected by ELISA technique. Results obtained from the study indicate that treatment of chlorhexidine-induced contact dermatitis by C5aR antagonist has managed to reduce the severity of the lesions similar to anti-histamine and corticosteroid treatment based on the gross skin lesion scoring and histopathological evaluation. The blood parameters did not showed any significant changes compared to normal. As a summary, C5aR antagonism provides an alternative towards the treatment of chlorhexidine-induced contact dermatitis.
format Project Paper Report
author Siong, Jing Jing
spellingShingle Siong, Jing Jing
The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
author_facet Siong, Jing Jing
author_sort Siong, Jing Jing
title The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
title_short The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
title_full The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
title_fullStr The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
title_full_unstemmed The effects of C5aR antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
title_sort effects of c5ar antagonism on histopathological and blood parameters changes following chlorhexidine-induced contact dermatitis in mice
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/83500/1/FPV%202015%2071%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/83500/
_version_ 1680322384102424576
score 13.211869

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