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Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats

Phyllanthus niruri, locally known as “Dukung Anak” is well-known for its therapeutic effect against hepatitis, urolithiasis, dysentery, influenza, jaundice and bacterial infection. Alcoholic liver disease (ALD) is a liver disease in human caused by alcohol consumption. It is a spectrum of disease wh...

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Main Author: Tan, Lai Ting
Format: Project Paper Report
Language:English
Published: 2015
Online Access:http://psasir.upm.edu.my/id/eprint/83427/1/FPV%202015%2036%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/83427/
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spelling my.upm.eprints.834272020-09-28T01:42:22Z http://psasir.upm.edu.my/id/eprint/83427/ Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats Tan, Lai Ting Phyllanthus niruri, locally known as “Dukung Anak” is well-known for its therapeutic effect against hepatitis, urolithiasis, dysentery, influenza, jaundice and bacterial infection. Alcoholic liver disease (ALD) is a liver disease in human caused by alcohol consumption. It is a spectrum of disease which started from hepatic steatosis to steatohepatitis and finally hepatic cirrhosis in chronic cases. In this study, the hepatoprotective effect of Phyllanthus niruri ethanolic extract was evaluated on alcohol and high cholesterol diet-induced liver cell damage in rats. A total of 20 rats were randomly divided into 5 groups comprised of group A (control), group B (alcohol and high cholesterol diet), groups C, D and E (given alcohol and high cholesterol diet, and supplemented with Phyllanthus niruri ethanolic extract at 75 mg/kg, 150 mg/kg, and 250 mg/kg respectively. The evaluation was carried out through analysis of liver parameters, lipid parameters and histopathological examination of liver at the end of experiment. Result showed that the relative liver weight of group C (3.36±0.07), D (3.35±0.11) and E (3.15±0.19) were significantly (p< 0.05) lower than group B (3.84±0.22). The serum low density lipoprotein (LDL) level was significantly (p<0.05) higher in group B (0.88±0.14 mmol/L) compared to Group A (0.49±0.05 mmol/L), D (0.62±0.06 mmol/L) and E (0.62±0.11mmol/L). However, there were no significant differences on liver parameters in all groups. The histopathological evaluation of the liver revealed that group B was having the highest steatosis score and both group A and E were having nearly similar steatosis score. In conclusion, Phyllanthus niruri ethanolic extract has hepatoprotective effect against alcohol and high cholesterol diet-induced liver injury in rats. 2015-03 Project Paper Report NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/83427/1/FPV%202015%2036%20-%20IR.pdf Tan, Lai Ting (2015) Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats. [Project Paper Report]
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Phyllanthus niruri, locally known as “Dukung Anak” is well-known for its therapeutic effect against hepatitis, urolithiasis, dysentery, influenza, jaundice and bacterial infection. Alcoholic liver disease (ALD) is a liver disease in human caused by alcohol consumption. It is a spectrum of disease which started from hepatic steatosis to steatohepatitis and finally hepatic cirrhosis in chronic cases. In this study, the hepatoprotective effect of Phyllanthus niruri ethanolic extract was evaluated on alcohol and high cholesterol diet-induced liver cell damage in rats. A total of 20 rats were randomly divided into 5 groups comprised of group A (control), group B (alcohol and high cholesterol diet), groups C, D and E (given alcohol and high cholesterol diet, and supplemented with Phyllanthus niruri ethanolic extract at 75 mg/kg, 150 mg/kg, and 250 mg/kg respectively. The evaluation was carried out through analysis of liver parameters, lipid parameters and histopathological examination of liver at the end of experiment. Result showed that the relative liver weight of group C (3.36±0.07), D (3.35±0.11) and E (3.15±0.19) were significantly (p< 0.05) lower than group B (3.84±0.22). The serum low density lipoprotein (LDL) level was significantly (p<0.05) higher in group B (0.88±0.14 mmol/L) compared to Group A (0.49±0.05 mmol/L), D (0.62±0.06 mmol/L) and E (0.62±0.11mmol/L). However, there were no significant differences on liver parameters in all groups. The histopathological evaluation of the liver revealed that group B was having the highest steatosis score and both group A and E were having nearly similar steatosis score. In conclusion, Phyllanthus niruri ethanolic extract has hepatoprotective effect against alcohol and high cholesterol diet-induced liver injury in rats.
format Project Paper Report
author Tan, Lai Ting
spellingShingle Tan, Lai Ting
Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
author_facet Tan, Lai Ting
author_sort Tan, Lai Ting
title Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
title_short Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
title_full Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
title_fullStr Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
title_full_unstemmed Hepatoprotective effect of Phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
title_sort hepatoprotective effect of phyllanthus niruri ethanolic extract on alcohol and high cholesterol diet-induced liver cell damage in rats
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/83427/1/FPV%202015%2036%20-%20IR.pdf
http://psasir.upm.edu.my/id/eprint/83427/
_version_ 1680322379897634816
score 13.211869

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