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Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects

Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at...

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Main Authors: Lye, Munn Sann, Shahbudin, Aishah Farhana, Tey, Yin Yee, Tor, Yin Sim, Ling, King Hwa, Ibrahim, Normala, Stanslas, Johnson, Loh, Su Peng, Rosli, Rozita
Format: Article
Language:English
Published: Neurotak Publishing 2019
Online Access:http://psasir.upm.edu.my/id/eprint/82774/1/Zinc%20transporter-3%20.pdf
http://psasir.upm.edu.my/id/eprint/82774/
https://neuroscirn.org/ojs/index.php/nrnotes/article/view/34
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spelling my.upm.eprints.827742021-06-01T22:01:08Z http://psasir.upm.edu.my/id/eprint/82774/ Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects Lye, Munn Sann Shahbudin, Aishah Farhana Tey, Yin Yee Tor, Yin Sim Ling, King Hwa Ibrahim, Normala Stanslas, Johnson Loh, Su Peng Rosli, Rozita Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of MDD. We hypothesise that variation in SLC30A3 (rs11126936) SNP increases risk of MDD. We recruited 300 MDD cases and 300 controls, matched in the ratio of 1:1 by age, gender and ethnicity. PCR-restriction fragment length polymorphism analysis was used in DNA genotyping, validated by sequencing 10% of samples. Deviation from the Hardy-Weinberg equilibrium was tested using the chi-square test. Conditional logistic regression was used to estimate adjusted odds ratios, controlling for age, gender, ethnicity, occupation and family monthly income. Genotypes G/G and G/T showed two times greater odds of developing MDD compared to variant genotype T/T (OR=1.983, 95% CI=1.031-3.815; p=0.040 and OR=2.232, 95% CI=1.100-4.533; p=0.026 respectively). Carriers of genotypes G/G and G/T of the SNP rs11126936 in SLC30A3 are associated with increased risk of MDD. Neurotak Publishing 2019-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82774/1/Zinc%20transporter-3%20.pdf Lye, Munn Sann and Shahbudin, Aishah Farhana and Tey, Yin Yee and Tor, Yin Sim and Ling, King Hwa and Ibrahim, Normala and Stanslas, Johnson and Loh, Su Peng and Rosli, Rozita (2019) Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects. Neuroscience Research Notes, 2 (3). pp. 20-28. ISSN 2576-828X https://neuroscirn.org/ojs/index.php/nrnotes/article/view/34 10.31117/neuroscirn.v2i3.34
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of MDD. We hypothesise that variation in SLC30A3 (rs11126936) SNP increases risk of MDD. We recruited 300 MDD cases and 300 controls, matched in the ratio of 1:1 by age, gender and ethnicity. PCR-restriction fragment length polymorphism analysis was used in DNA genotyping, validated by sequencing 10% of samples. Deviation from the Hardy-Weinberg equilibrium was tested using the chi-square test. Conditional logistic regression was used to estimate adjusted odds ratios, controlling for age, gender, ethnicity, occupation and family monthly income. Genotypes G/G and G/T showed two times greater odds of developing MDD compared to variant genotype T/T (OR=1.983, 95% CI=1.031-3.815; p=0.040 and OR=2.232, 95% CI=1.100-4.533; p=0.026 respectively). Carriers of genotypes G/G and G/T of the SNP rs11126936 in SLC30A3 are associated with increased risk of MDD.
format Article
author Lye, Munn Sann
Shahbudin, Aishah Farhana
Tey, Yin Yee
Tor, Yin Sim
Ling, King Hwa
Ibrahim, Normala
Stanslas, Johnson
Loh, Su Peng
Rosli, Rozita
spellingShingle Lye, Munn Sann
Shahbudin, Aishah Farhana
Tey, Yin Yee
Tor, Yin Sim
Ling, King Hwa
Ibrahim, Normala
Stanslas, Johnson
Loh, Su Peng
Rosli, Rozita
Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
author_facet Lye, Munn Sann
Shahbudin, Aishah Farhana
Tey, Yin Yee
Tor, Yin Sim
Ling, King Hwa
Ibrahim, Normala
Stanslas, Johnson
Loh, Su Peng
Rosli, Rozita
author_sort Lye, Munn Sann
title Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
title_short Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
title_full Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
title_fullStr Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
title_full_unstemmed Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
title_sort zinc transporter-3 [slc30a3 (rs11126936)] polymorphism is associated with major depressive disorder in asian subjects
publisher Neurotak Publishing
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/82774/1/Zinc%20transporter-3%20.pdf
http://psasir.upm.edu.my/id/eprint/82774/
https://neuroscirn.org/ojs/index.php/nrnotes/article/view/34
_version_ 1702171458849996800
score 13.222552

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