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Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide

Diagnostic imaging can be applied in the management of Alzheimer’s disease as it provides structural and functional information to exclude possible secondary causes and offers additional information, especially in atypical cases of Alzheimer’s disease. The utility of positron emission tomography/com...

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Main Authors: Abdul Aziz, Siti Aishah, Loh, Jia Ling, Ahmad Saad, Fathinul Fikri, Nordin, Abdul Jalil, Ibrahim, Normala, Nuruddin, Arlina, Tunan, Elinda, Rosalina, Saripan, M. Iqbal, Suppiah, Subapriya
Format: Article
Language:English
Published: Universitas Indonesia 2019
Online Access:http://psasir.upm.edu.my/id/eprint/82740/1/Voxel-wise%20analysis%20of%2018F-fluorodeoxyglucose%20metabolism%20in%20correlation%20with%20variations%20in%20the%20presentation%20of%20Alzheimers%20disease%20a%20clinicians%20guide.pdf
http://psasir.upm.edu.my/id/eprint/82740/
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spelling my.upm.eprints.827402020-09-11T04:35:22Z http://psasir.upm.edu.my/id/eprint/82740/ Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide Abdul Aziz, Siti Aishah Loh, Jia Ling Ahmad Saad, Fathinul Fikri Nordin, Abdul Jalil Ibrahim, Normala Nuruddin, Arlina Tunan, Elinda Rosalina Saripan, M. Iqbal Suppiah, Subapriya Diagnostic imaging can be applied in the management of Alzheimer’s disease as it provides structural and functional information to exclude possible secondary causes and offers additional information, especially in atypical cases of Alzheimer’s disease. The utility of positron emission tomography/computed tomography (PET/CT) can help in the noninvasive diagnosis of Alzheimer’s disease by voxel-wise quantification of cerebral 18F-fluorodeoxyglucose (FDG) metabolism. Methods: This prospective study was conducted among 10 subjects with Alzheimer’s disease and 10 healthy control subjects who underwent neuropsychological testing and 18F-FDG PET/CT scans. Images of the brain were postprocessed using voxel-wise analysis and segmented into 20 regions of interest. The standardized uptake value (SUV)max/SUVmean/standard deviation of SUVmean results were analyzed accordingly and correlated with the subjects’ Montreal cognitive assessment (MoCA) results that were adjusted for age and education level. Results: Hypometabolism at the right parietal lobe significantly correlated with increasing age and lower MoCA scores. Global hypometabolism was observed in subjects who had advanced Alzheimer’s disease but preserved primary somatosensory cortices (S1) region metabolism. Predominance of frontal lobe hypometabolism was a feature of subjects with Alzheimer’s disease having associated depressive symptoms. Conclusions: 18F-FDG PET/CT voxel-wise analysis can be used for quantitative assessment and can assist clinicians in the diagnosis of Alzheimer’s disease and other variations of the disease spectrum. Universitas Indonesia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82740/1/Voxel-wise%20analysis%20of%2018F-fluorodeoxyglucose%20metabolism%20in%20correlation%20with%20variations%20in%20the%20presentation%20of%20Alzheimers%20disease%20a%20clinicians%20guide.pdf Abdul Aziz, Siti Aishah and Loh, Jia Ling and Ahmad Saad, Fathinul Fikri and Nordin, Abdul Jalil and Ibrahim, Normala and Nuruddin, Arlina and Tunan, Elinda and Rosalina and Saripan, M. Iqbal and Suppiah, Subapriya (2019) Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide. Medical Journal of Indonesia, 28 (3). pp. 300-308. ISSN 0853-1773;ESSN: 2252-8083 10.13181/mji.v28i3.2770
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Diagnostic imaging can be applied in the management of Alzheimer’s disease as it provides structural and functional information to exclude possible secondary causes and offers additional information, especially in atypical cases of Alzheimer’s disease. The utility of positron emission tomography/computed tomography (PET/CT) can help in the noninvasive diagnosis of Alzheimer’s disease by voxel-wise quantification of cerebral 18F-fluorodeoxyglucose (FDG) metabolism. Methods: This prospective study was conducted among 10 subjects with Alzheimer’s disease and 10 healthy control subjects who underwent neuropsychological testing and 18F-FDG PET/CT scans. Images of the brain were postprocessed using voxel-wise analysis and segmented into 20 regions of interest. The standardized uptake value (SUV)max/SUVmean/standard deviation of SUVmean results were analyzed accordingly and correlated with the subjects’ Montreal cognitive assessment (MoCA) results that were adjusted for age and education level. Results: Hypometabolism at the right parietal lobe significantly correlated with increasing age and lower MoCA scores. Global hypometabolism was observed in subjects who had advanced Alzheimer’s disease but preserved primary somatosensory cortices (S1) region metabolism. Predominance of frontal lobe hypometabolism was a feature of subjects with Alzheimer’s disease having associated depressive symptoms. Conclusions: 18F-FDG PET/CT voxel-wise analysis can be used for quantitative assessment and can assist clinicians in the diagnosis of Alzheimer’s disease and other variations of the disease spectrum.
format Article
author Abdul Aziz, Siti Aishah
Loh, Jia Ling
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
Ibrahim, Normala
Nuruddin, Arlina
Tunan, Elinda
Rosalina
Saripan, M. Iqbal
Suppiah, Subapriya
spellingShingle Abdul Aziz, Siti Aishah
Loh, Jia Ling
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
Ibrahim, Normala
Nuruddin, Arlina
Tunan, Elinda
Rosalina
Saripan, M. Iqbal
Suppiah, Subapriya
Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
author_facet Abdul Aziz, Siti Aishah
Loh, Jia Ling
Ahmad Saad, Fathinul Fikri
Nordin, Abdul Jalil
Ibrahim, Normala
Nuruddin, Arlina
Tunan, Elinda
Rosalina
Saripan, M. Iqbal
Suppiah, Subapriya
author_sort Abdul Aziz, Siti Aishah
title Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
title_short Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
title_full Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
title_fullStr Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
title_full_unstemmed Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
title_sort voxel-wise analysis of 18f-fluorodeoxyglucose metabolism in correlation with variations in the presentation of alzheimer’s disease: a clinician’s guide
publisher Universitas Indonesia
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/82740/1/Voxel-wise%20analysis%20of%2018F-fluorodeoxyglucose%20metabolism%20in%20correlation%20with%20variations%20in%20the%20presentation%20of%20Alzheimers%20disease%20a%20clinicians%20guide.pdf
http://psasir.upm.edu.my/id/eprint/82740/
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score 13.211869

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