Cover Image

V protein, the virulence factor across the family Paramyxoviridae: a review

Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubu...

Full description

Saved in:
Bibliographic Details
Main Authors: May, Ling Tham, Yusoff, Khatijah, Othman, Siti Sarah, Suet, Lin Chia
Format: Article
Language:English
Published: Malaysian Society for Molecular Biology and Biotechnology 2019
Online Access:http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf
http://psasir.upm.edu.my/id/eprint/82701/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.82701
record_format eprints
spelling my.upm.eprints.827012020-09-14T08:17:26Z http://psasir.upm.edu.my/id/eprint/82701/ V protein, the virulence factor across the family Paramyxoviridae: a review May, Ling Tham Yusoff, Khatijah Othman, Siti Sarah Suet, Lin Chia Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubulavirus. The members within this family are negative and single-stranded RNA viruses including human and animal pathogens such as measles virus (MeV), Nipah virus (NiV), mumps virus (MuV), Sendai virus (SeV) and Newcastle disease virus (NDV). The V protein is conserved within the family and plays an essential role in viral pathogenicity. Although V proteins of many paramyxoviruses are interferon-antagonists which counteract with the host’s innate immunity, there are still differences in the mode of action of the V protein between different genera or species within the same genera. The strategies to circumvent the host interferon (IFN) pathway can be divided into three general mechanisms; degradation of signal transducers and activators of transcription (STAT) protein, inhibition of phosphorylation of the transcription factor and, inhibition of translocation of STAT proteins into the nucleus. As a result, inhibition of IFN signalling and production promotes viral replication in the host cells. This review highlights the mechanism of the paramyxoviral V protein in evading the host IFN system. Malaysian Society for Molecular Biology and Biotechnology 2019-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf May, Ling Tham and Yusoff, Khatijah and Othman, Siti Sarah and Suet, Lin Chia (2019) V protein, the virulence factor across the family Paramyxoviridae: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (3). pp. 73-85. ISSN 0128-7451; ESSN: 2672-7277 10.35118/apjmbb.2019.027.3.08
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubulavirus. The members within this family are negative and single-stranded RNA viruses including human and animal pathogens such as measles virus (MeV), Nipah virus (NiV), mumps virus (MuV), Sendai virus (SeV) and Newcastle disease virus (NDV). The V protein is conserved within the family and plays an essential role in viral pathogenicity. Although V proteins of many paramyxoviruses are interferon-antagonists which counteract with the host’s innate immunity, there are still differences in the mode of action of the V protein between different genera or species within the same genera. The strategies to circumvent the host interferon (IFN) pathway can be divided into three general mechanisms; degradation of signal transducers and activators of transcription (STAT) protein, inhibition of phosphorylation of the transcription factor and, inhibition of translocation of STAT proteins into the nucleus. As a result, inhibition of IFN signalling and production promotes viral replication in the host cells. This review highlights the mechanism of the paramyxoviral V protein in evading the host IFN system.
format Article
author May, Ling Tham
Yusoff, Khatijah
Othman, Siti Sarah
Suet, Lin Chia
spellingShingle May, Ling Tham
Yusoff, Khatijah
Othman, Siti Sarah
Suet, Lin Chia
V protein, the virulence factor across the family Paramyxoviridae: a review
author_facet May, Ling Tham
Yusoff, Khatijah
Othman, Siti Sarah
Suet, Lin Chia
author_sort May, Ling Tham
title V protein, the virulence factor across the family Paramyxoviridae: a review
title_short V protein, the virulence factor across the family Paramyxoviridae: a review
title_full V protein, the virulence factor across the family Paramyxoviridae: a review
title_fullStr V protein, the virulence factor across the family Paramyxoviridae: a review
title_full_unstemmed V protein, the virulence factor across the family Paramyxoviridae: a review
title_sort v protein, the virulence factor across the family paramyxoviridae: a review
publisher Malaysian Society for Molecular Biology and Biotechnology
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf
http://psasir.upm.edu.my/id/eprint/82701/
_version_ 1678594253561790464
score 13.211869

Similar Items