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Some chemical carcinogens for leukaemia induction and their animal models

Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal m...

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Main Authors: Aliyu, Abdullahi, Shaari, Mohd Rosly, Mustapha, Noordin Mohamed, Ahmad Sayuti, Nurul Syahirah, Reduan, Mohd Farhan Hanif, Sithambaram, Shanmugavelu, Shaari, Khozirah, Hamzah, Hazilawati
Format: Article
Language:English
Published: Sciencedomain International 2019
Online Access:http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf
http://psasir.upm.edu.my/id/eprint/82211/
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spelling my.upm.eprints.822112020-12-16T14:29:38Z http://psasir.upm.edu.my/id/eprint/82211/ Some chemical carcinogens for leukaemia induction and their animal models Aliyu, Abdullahi Shaari, Mohd Rosly Mustapha, Noordin Mohamed Ahmad Sayuti, Nurul Syahirah Reduan, Mohd Farhan Hanif Sithambaram, Shanmugavelu Shaari, Khozirah Hamzah, Hazilawati Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment. Sciencedomain International 2019-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf Aliyu, Abdullahi and Shaari, Mohd Rosly and Mustapha, Noordin Mohamed and Ahmad Sayuti, Nurul Syahirah and Reduan, Mohd Farhan Hanif and Sithambaram, Shanmugavelu and Shaari, Khozirah and Hamzah, Hazilawati (2019) Some chemical carcinogens for leukaemia induction and their animal models. Annual Research & Review in Biology, 33 (1). art. no. ARRB.50887. pp. 1-7. ISSN 2347-565X 10.9734/ARRB/2019/v33i130108
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment.
format Article
author Aliyu, Abdullahi
Shaari, Mohd Rosly
Mustapha, Noordin Mohamed
Ahmad Sayuti, Nurul Syahirah
Reduan, Mohd Farhan Hanif
Sithambaram, Shanmugavelu
Shaari, Khozirah
Hamzah, Hazilawati
spellingShingle Aliyu, Abdullahi
Shaari, Mohd Rosly
Mustapha, Noordin Mohamed
Ahmad Sayuti, Nurul Syahirah
Reduan, Mohd Farhan Hanif
Sithambaram, Shanmugavelu
Shaari, Khozirah
Hamzah, Hazilawati
Some chemical carcinogens for leukaemia induction and their animal models
author_facet Aliyu, Abdullahi
Shaari, Mohd Rosly
Mustapha, Noordin Mohamed
Ahmad Sayuti, Nurul Syahirah
Reduan, Mohd Farhan Hanif
Sithambaram, Shanmugavelu
Shaari, Khozirah
Hamzah, Hazilawati
author_sort Aliyu, Abdullahi
title Some chemical carcinogens for leukaemia induction and their animal models
title_short Some chemical carcinogens for leukaemia induction and their animal models
title_full Some chemical carcinogens for leukaemia induction and their animal models
title_fullStr Some chemical carcinogens for leukaemia induction and their animal models
title_full_unstemmed Some chemical carcinogens for leukaemia induction and their animal models
title_sort some chemical carcinogens for leukaemia induction and their animal models
publisher Sciencedomain International
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf
http://psasir.upm.edu.my/id/eprint/82211/
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score 13.211869

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