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Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and its mechanism of action remains unknown. The ability of cytokine-related apoptosis-inducin...

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Main Authors: Raihan, Juraimi, Ahmad, Umar, Yong, Felix Yoke Keong, Eshak, Zolkapli, Othman, Fauziah, Ideris, Aini
Format: Article
Language:English
Published: BioMed Central 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81953/1/Regression%20of%20solid%20breast%20tumours%20in%20mice%20by%20Newcastle%20disease%20virus%20is%20associated%20with%20production%20of%20apoptosis%20related-cytokines.pdf
http://psasir.upm.edu.my/id/eprint/81953/
http://www.biomedcentral.com/bmccancer/
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spelling my.upm.eprints.819532020-09-10T08:20:04Z http://psasir.upm.edu.my/id/eprint/81953/ Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines Raihan, Juraimi Ahmad, Umar Yong, Felix Yoke Keong Eshak, Zolkapli Othman, Fauziah Ideris, Aini Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and its mechanism of action remains unknown. The ability of cytokine-related apoptosis-inducing NDV AF2240 to treat breast cancer was investigated in the current study. Methods A total of 90 mice were used and divided into 15 groups, each group comprising of 6 mice. Tumour, body weight and mortality of the mice were determined throughout the experiment, to observe the effect of NDV and NDV + tamoxifen treatments on the mice. In addition, the toxic effect of the treatments was determined through liver function test. In order to elucidate the involvement of cytokine production induced by NDV, a total of six cytokines, i.e. IL-6, IFN-γ, MCP-1, IL-10, IL12p70 and TNF-α were measured using cytometric bead array assay (plasma) and enzyme-linked immunosorbent spot (isolated splenocytes). Results The results demonstrated that 4 T1 breast cancer cells in allotransplanted mice treated with AF2240 showed a noticeable inhibition of tumour growth and induce apoptotic-related cytokines. Conclusions NDV AF2240 suppression of breast tumour growth is associated with induction of apoptotic-related cytokines. It would be important to further investigate the molecular mechanism underlaying cytokines production by Newcastle disease virus. Electronic supplementary material The online version of this article (10.1186/s12885-019-5516-5) contains supplementary material, which is available to authorized users. BioMed Central 2019-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81953/1/Regression%20of%20solid%20breast%20tumours%20in%20mice%20by%20Newcastle%20disease%20virus%20is%20associated%20with%20production%20of%20apoptosis%20related-cytokines.pdf Raihan, Juraimi and Ahmad, Umar and Yong, Felix Yoke Keong and Eshak, Zolkapli and Othman, Fauziah and Ideris, Aini (2019) Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines. BMC Cancer, 19 (315). pp. 1-13. ISSN 1471-2407 http://www.biomedcentral.com/bmccancer/ 10.1186/s12885-019-5516-5
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and its mechanism of action remains unknown. The ability of cytokine-related apoptosis-inducing NDV AF2240 to treat breast cancer was investigated in the current study. Methods A total of 90 mice were used and divided into 15 groups, each group comprising of 6 mice. Tumour, body weight and mortality of the mice were determined throughout the experiment, to observe the effect of NDV and NDV + tamoxifen treatments on the mice. In addition, the toxic effect of the treatments was determined through liver function test. In order to elucidate the involvement of cytokine production induced by NDV, a total of six cytokines, i.e. IL-6, IFN-γ, MCP-1, IL-10, IL12p70 and TNF-α were measured using cytometric bead array assay (plasma) and enzyme-linked immunosorbent spot (isolated splenocytes). Results The results demonstrated that 4 T1 breast cancer cells in allotransplanted mice treated with AF2240 showed a noticeable inhibition of tumour growth and induce apoptotic-related cytokines. Conclusions NDV AF2240 suppression of breast tumour growth is associated with induction of apoptotic-related cytokines. It would be important to further investigate the molecular mechanism underlaying cytokines production by Newcastle disease virus. Electronic supplementary material The online version of this article (10.1186/s12885-019-5516-5) contains supplementary material, which is available to authorized users.
format Article
author Raihan, Juraimi
Ahmad, Umar
Yong, Felix Yoke Keong
Eshak, Zolkapli
Othman, Fauziah
Ideris, Aini
spellingShingle Raihan, Juraimi
Ahmad, Umar
Yong, Felix Yoke Keong
Eshak, Zolkapli
Othman, Fauziah
Ideris, Aini
Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
author_facet Raihan, Juraimi
Ahmad, Umar
Yong, Felix Yoke Keong
Eshak, Zolkapli
Othman, Fauziah
Ideris, Aini
author_sort Raihan, Juraimi
title Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
title_short Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
title_full Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
title_fullStr Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
title_full_unstemmed Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines
title_sort regression of solid breast tumours in mice by newcastle disease virus is associated with production of apoptosis related-cytokines
publisher BioMed Central
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81953/1/Regression%20of%20solid%20breast%20tumours%20in%20mice%20by%20Newcastle%20disease%20virus%20is%20associated%20with%20production%20of%20apoptosis%20related-cytokines.pdf
http://psasir.upm.edu.my/id/eprint/81953/
http://www.biomedcentral.com/bmccancer/
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score 13.211869

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