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Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study

Objectives: Nonalcoholic fatty liver disease (NAFLD) is a very common liver disorder in Western countries. As of late, it has been found to be prevalent in Asia as well. It is a benign disease unless it develops into necroinflammation and fibrosis. This study was proposed to determine the prevalence...

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Main Authors: Khammas, Abdul Sattar Arif, Abu Hassan, Hasyma, M. Salih, Sarah Qahtan, Shahar, Hayati Kadir, Mohamad Ibrahim, Ramlah, Mohamad Nasir, Nurul Nadiah, Mahmud, Rozi
Format: Article
Language:English
Published: Elsevier Espana 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81826/1/Prevalence%20and%20risk%20factors%20of%20sonographically%20detected%20non%20alcoholic%20fatty%20liver%20disease%20in%20a%20screening%20centre%20in%20Klang%20Valley%2C%20Malaysia%20an%20observational%20cross-sectional%20study.pdf
http://psasir.upm.edu.my/id/eprint/81826/
https://journals.lww.com/pbj/Fulltext/2019/04000/Prevalence_and_risk_factors_of_sonographically.4.aspx
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spelling my.upm.eprints.818262020-11-26T21:40:30Z http://psasir.upm.edu.my/id/eprint/81826/ Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study Khammas, Abdul Sattar Arif Abu Hassan, Hasyma M. Salih, Sarah Qahtan Shahar, Hayati Kadir Mohamad Ibrahim, Ramlah Mohamad Nasir, Nurul Nadiah Mahmud, Rozi Objectives: Nonalcoholic fatty liver disease (NAFLD) is a very common liver disorder in Western countries. As of late, it has been found to be prevalent in Asia as well. It is a benign disease unless it develops into necroinflammation and fibrosis. This study was proposed to determine the prevalence and risk factors of sonography-detected NAFLD among Malaysian adults in Klang Valley, West Malaysia. Study design: An observational cross-sectional study. Methods: The participants were aged between 45 and 75 years who participated in a screening program at the Golden Horses Health Sanctuary in Klang Valley. Lipid profile and anthropometric measurements were collected from the subjects’ medical records. Ultrasound machine and a structured self-administered questionnaire were used as instruments for recruiting data from the subjects. The subjects who consumed alcohol (>140 g/wk for men and >70 g/wk for females), had hepatitis B or C viruses, liver insults, and surgery, and taken lipid-lowering medications were excluded from the study. Results: A total of 628 subjects were analyzed, and 235 (37.4%) subjects were diagnosed with definite NAFLD. They comprised 518 (82.5%) Chinese, 92 (14.6%) Malays, and 18 (2.9%) Indians. Peak prevalence of NAFLD was found in 53 to 60 years age group. The higher prevalence of NAFLD was among men (48.3%) than women (27.3%) and among Indians (61.1%) and Malays (51.1%) than among Chinese (34.2%). NAFLD has been found to be strongly correlated with male sex, high body mass index (≥23.0 kg/m2), hypertriglyceridemia, low high-density lipoprotein cholesterol, diabetes mellitus, and hypertension. Conclusion:NAFLD is quite common among adults in Malaysian urban population. The prevalence of NAFLD was inordinately high among the 53 to 60 years age group, male sex, Indians, and Malays (as compared with Chinese). Age >60 years, male sex, high bodybmass index (≥23.0 kg/m2), hypertriglyceridemia, and diabetes mellitus were proven to be risk predictors for NAFLD. Elsevier Espana 2019-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81826/1/Prevalence%20and%20risk%20factors%20of%20sonographically%20detected%20non%20alcoholic%20fatty%20liver%20disease%20in%20a%20screening%20centre%20in%20Klang%20Valley%2C%20Malaysia%20an%20observational%20cross-sectional%20study.pdf Khammas, Abdul Sattar Arif and Abu Hassan, Hasyma and M. Salih, Sarah Qahtan and Shahar, Hayati Kadir and Mohamad Ibrahim, Ramlah and Mohamad Nasir, Nurul Nadiah and Mahmud, Rozi (2019) Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study. Porto Biomedical Journal, 4 (2). pp. 1-7. ISSN 2444-8664 https://journals.lww.com/pbj/Fulltext/2019/04000/Prevalence_and_risk_factors_of_sonographically.4.aspx 10.1016/j.pbj.0000000000000031
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objectives: Nonalcoholic fatty liver disease (NAFLD) is a very common liver disorder in Western countries. As of late, it has been found to be prevalent in Asia as well. It is a benign disease unless it develops into necroinflammation and fibrosis. This study was proposed to determine the prevalence and risk factors of sonography-detected NAFLD among Malaysian adults in Klang Valley, West Malaysia. Study design: An observational cross-sectional study. Methods: The participants were aged between 45 and 75 years who participated in a screening program at the Golden Horses Health Sanctuary in Klang Valley. Lipid profile and anthropometric measurements were collected from the subjects’ medical records. Ultrasound machine and a structured self-administered questionnaire were used as instruments for recruiting data from the subjects. The subjects who consumed alcohol (>140 g/wk for men and >70 g/wk for females), had hepatitis B or C viruses, liver insults, and surgery, and taken lipid-lowering medications were excluded from the study. Results: A total of 628 subjects were analyzed, and 235 (37.4%) subjects were diagnosed with definite NAFLD. They comprised 518 (82.5%) Chinese, 92 (14.6%) Malays, and 18 (2.9%) Indians. Peak prevalence of NAFLD was found in 53 to 60 years age group. The higher prevalence of NAFLD was among men (48.3%) than women (27.3%) and among Indians (61.1%) and Malays (51.1%) than among Chinese (34.2%). NAFLD has been found to be strongly correlated with male sex, high body mass index (≥23.0 kg/m2), hypertriglyceridemia, low high-density lipoprotein cholesterol, diabetes mellitus, and hypertension. Conclusion:NAFLD is quite common among adults in Malaysian urban population. The prevalence of NAFLD was inordinately high among the 53 to 60 years age group, male sex, Indians, and Malays (as compared with Chinese). Age >60 years, male sex, high bodybmass index (≥23.0 kg/m2), hypertriglyceridemia, and diabetes mellitus were proven to be risk predictors for NAFLD.
format Article
author Khammas, Abdul Sattar Arif
Abu Hassan, Hasyma
M. Salih, Sarah Qahtan
Shahar, Hayati Kadir
Mohamad Ibrahim, Ramlah
Mohamad Nasir, Nurul Nadiah
Mahmud, Rozi
spellingShingle Khammas, Abdul Sattar Arif
Abu Hassan, Hasyma
M. Salih, Sarah Qahtan
Shahar, Hayati Kadir
Mohamad Ibrahim, Ramlah
Mohamad Nasir, Nurul Nadiah
Mahmud, Rozi
Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
author_facet Khammas, Abdul Sattar Arif
Abu Hassan, Hasyma
M. Salih, Sarah Qahtan
Shahar, Hayati Kadir
Mohamad Ibrahim, Ramlah
Mohamad Nasir, Nurul Nadiah
Mahmud, Rozi
author_sort Khammas, Abdul Sattar Arif
title Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
title_short Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
title_full Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
title_fullStr Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
title_full_unstemmed Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
title_sort prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in klang valley, malaysia: an observational cross-sectional study
publisher Elsevier Espana
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81826/1/Prevalence%20and%20risk%20factors%20of%20sonographically%20detected%20non%20alcoholic%20fatty%20liver%20disease%20in%20a%20screening%20centre%20in%20Klang%20Valley%2C%20Malaysia%20an%20observational%20cross-sectional%20study.pdf
http://psasir.upm.edu.my/id/eprint/81826/
https://journals.lww.com/pbj/Fulltext/2019/04000/Prevalence_and_risk_factors_of_sonographically.4.aspx
_version_ 1685580248436965376
score 13.211869

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