Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics
Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three developmental stages (seven, eight and nine months old) using nuclear...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academic Press
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/81737/1/Phytochemical%20and%20bioactivity%20alterations.pdf http://psasir.upm.edu.my/id/eprint/81737/ https://www.sciencedirect.com/science/article/pii/S0889157519300389 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the
metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three
developmental stages (seven, eight and nine months old) using nuclear magnetic resonance (NMR)-based metabolomics. Principal component analysis (PCA) showed that there are metabolites changes due to the month of
harvest in each of the four species. A large quantity of curcumin and demethoxycurcumin contributed to the
separation of C. xanthorrhiza, whereas the diterpenoids, such as curcumanggoside, (E)-labda-8(17),12-diene15,16-dial, calcaratarin A and zerumin B were responsible for the discrimination of C. mangga. Eight-month-old
C. xanthorrhiza exhibited the highest nitric oxide (NO) inhibitory activity, while nine-month-old C. mangga
exhibited the highest α-glucosidase inhibitory activity. The correlation among the bioactivities and phytochemical constituents was determined using partial least square (PLS) analysis. Curcumin, demethoxycurcumin,
germacrone, zedoarol and xanthorrhizol were correlated with the NO inhibitory activity in C. xanthorrhiza,
whereas curcumanggoside, labda-8(17),12-diene-15,16-dial and zerumin B were correlated with the α-glucosidase inhibitory activity in C. mangga. From the phytochemical markers and metabolic changes among growth
stages of C. xanthorrhiza and C. mangga, the biosynthetic pathway was proposed to show the metabolites that
might contribute to their health benefits. |
|---|