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Orexin and male reproduction

Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong to the Family of G-protein coupled receptors....

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Main Authors: Sengupta, Pallav, Dutta, Sulagna, Tusimin, Maiza, Karkada, Ivan Rolland
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81588/1/Orexin%20and%20male%20reproduction.pdf
http://psasir.upm.edu.my/id/eprint/81588/
https://www.researchgate.net/publication/336344436_Orexins_and_male_reproduction
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spelling my.upm.eprints.815882020-11-02T19:25:20Z http://psasir.upm.edu.my/id/eprint/81588/ Orexin and male reproduction Sengupta, Pallav Dutta, Sulagna Tusimin, Maiza Karkada, Ivan Rolland Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong to the Family of G-protein coupled receptors. The primary function of the orexin system, i.e. the orexins, their receptors and associated neuronal circuitries, perhaps is to increase spontaneous physical activity and food intake, thereby promoting an increase in energy expenditure. Reports suggest that orexins may be the key brain components to mediate the mechanism of obesity resistance. Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. Moreover, orexins have been reported to greatly influence gonadotropin-releasing hormone neurons and their secretions to regulate reproductive functions via modulation of the hypothalamic-pituitary-gonadal axis. Evidence thus implicates participation of orexins in steroidogenesis, spermatogenesis, transportation and maturation of sperm as well as in the control of penile function. However, further research is required in this direction to elucidate the mechanisms by which orexins play a role in different testicular functions and effect of orexins on semen quality. Wolters Kluwer Medknow Publications 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81588/1/Orexin%20and%20male%20reproduction.pdf Sengupta, Pallav and Dutta, Sulagna and Tusimin, Maiza and Karkada, Ivan Rolland (2019) Orexin and male reproduction. Asian Pacific Journal of Reproduction, 8 (5). pp. 233-238. ISSN 2305-0500; ESSN: 2305-0519 https://www.researchgate.net/publication/336344436_Orexins_and_male_reproduction 10.4103/2305-0500.268145
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong to the Family of G-protein coupled receptors. The primary function of the orexin system, i.e. the orexins, their receptors and associated neuronal circuitries, perhaps is to increase spontaneous physical activity and food intake, thereby promoting an increase in energy expenditure. Reports suggest that orexins may be the key brain components to mediate the mechanism of obesity resistance. Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. Moreover, orexins have been reported to greatly influence gonadotropin-releasing hormone neurons and their secretions to regulate reproductive functions via modulation of the hypothalamic-pituitary-gonadal axis. Evidence thus implicates participation of orexins in steroidogenesis, spermatogenesis, transportation and maturation of sperm as well as in the control of penile function. However, further research is required in this direction to elucidate the mechanisms by which orexins play a role in different testicular functions and effect of orexins on semen quality.
format Article
author Sengupta, Pallav
Dutta, Sulagna
Tusimin, Maiza
Karkada, Ivan Rolland
spellingShingle Sengupta, Pallav
Dutta, Sulagna
Tusimin, Maiza
Karkada, Ivan Rolland
Orexin and male reproduction
author_facet Sengupta, Pallav
Dutta, Sulagna
Tusimin, Maiza
Karkada, Ivan Rolland
author_sort Sengupta, Pallav
title Orexin and male reproduction
title_short Orexin and male reproduction
title_full Orexin and male reproduction
title_fullStr Orexin and male reproduction
title_full_unstemmed Orexin and male reproduction
title_sort orexin and male reproduction
publisher Wolters Kluwer Medknow Publications
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81588/1/Orexin%20and%20male%20reproduction.pdf
http://psasir.upm.edu.my/id/eprint/81588/
https://www.researchgate.net/publication/336344436_Orexins_and_male_reproduction
_version_ 1682298732603768832
score 13.211869

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