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Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats

Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. Howeve...

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Main Authors: Nikbakht, Elham, Jamaluddin, Rosita, Sabran, Mohd Redzwan, Khalesi, Saman
Format: Article
Language:English
Published: Hogrefe Verlag GmbH and Co. KG 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf
http://psasir.upm.edu.my/id/eprint/81586/
https://pubmed.ncbi.nlm.nih.gov/31056010/
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spelling my.upm.eprints.815862020-11-02T19:34:48Z http://psasir.upm.edu.my/id/eprint/81586/ Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats Nikbakht, Elham Jamaluddin, Rosita Sabran, Mohd Redzwan Khalesi, Saman Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB₁ in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB₁ only (n = 9); AFB₁ treated with LcS (n = 9); and control (no AFB₁ exposure) (n = 6) groups. The blood AFB₁ level of rats treated with LcS was slightly lower than the untreated AFB₁ induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g-1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB₁ induced rats. However, a trend for a significant difference was only observed in ALT of AFB₁ induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats' body weight decreased in all animals force-fed with AFB₁ with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB₁ in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings. Hogrefe Verlag GmbH and Co. KG 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf Nikbakht, Elham and Jamaluddin, Rosita and Sabran, Mohd Redzwan and Khalesi, Saman (2019) Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats. International Journal for Vitamin and Nutrition Research, 88 (3-4). pp. 199-208. ISSN 1664-2821; ESSN: 0300-9831 https://pubmed.ncbi.nlm.nih.gov/31056010/ 10.1024/0300-9831/a000513
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB₁ in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB₁ only (n = 9); AFB₁ treated with LcS (n = 9); and control (no AFB₁ exposure) (n = 6) groups. The blood AFB₁ level of rats treated with LcS was slightly lower than the untreated AFB₁ induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g-1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB₁ induced rats. However, a trend for a significant difference was only observed in ALT of AFB₁ induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats' body weight decreased in all animals force-fed with AFB₁ with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB₁ in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings.
format Article
author Nikbakht, Elham
Jamaluddin, Rosita
Sabran, Mohd Redzwan
Khalesi, Saman
spellingShingle Nikbakht, Elham
Jamaluddin, Rosita
Sabran, Mohd Redzwan
Khalesi, Saman
Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
author_facet Nikbakht, Elham
Jamaluddin, Rosita
Sabran, Mohd Redzwan
Khalesi, Saman
author_sort Nikbakht, Elham
title Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
title_short Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
title_full Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
title_fullStr Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
title_full_unstemmed Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
title_sort oral administration of lactobacillus casei shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
publisher Hogrefe Verlag GmbH and Co. KG
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf
http://psasir.upm.edu.my/id/eprint/81586/
https://pubmed.ncbi.nlm.nih.gov/31056010/
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score 13.211869

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