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Development of metal-organic frameworks for biomedical applications - a review

Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs sy...

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Main Authors: Mostafa, Yousefzadeh Borzehandani, Abdul Malek, Emilia, Abdul Rahman, Mohd Basyaruddin, Mohammad Latif, Muhammad Alif
Format: Article
Language:English
Published: Naci kalkan 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf
http://psasir.upm.edu.my/id/eprint/81158/
http://www.jmest.org/wp-content/uploads/JMESTN42353068.pdf
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spelling my.upm.eprints.811582020-09-09T07:42:12Z http://psasir.upm.edu.my/id/eprint/81158/ Development of metal-organic frameworks for biomedical applications - a review Mostafa, Yousefzadeh Borzehandani Abdul Malek, Emilia Abdul Rahman, Mohd Basyaruddin Mohammad Latif, Muhammad Alif Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs synthesis as well as their toxicological properties. We also highlighted the potential of MOFs as therapeutic agents and nano-MOFs (NMOFs) for biomedical sensing. Water as an alternative media for MOF synthesis showed excellent results in term of particle size, stability and selectivity. Toxicological assessments revealed Fe (III) and MIL-100 as the most promising metal and MOF for medical applications. It was also shown that MOFs are sensitive towards physiological and pathological criteria such as pH, fluorescence and O2. Although many attempts have been made in utilizing MOFs for bio applications, further improvements should be considered before MOFs can become effective therapeutics options. Naci kalkan 2019-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf Mostafa, Yousefzadeh Borzehandani and Abdul Malek, Emilia and Abdul Rahman, Mohd Basyaruddin and Mohammad Latif, Muhammad Alif (2019) Development of metal-organic frameworks for biomedical applications - a review. Journal of Multidisciplinary Engineering Science and Technology, 6 (12). art. no. 42353068. pp. 105-116. ISSN 2458-9403 http://www.jmest.org/wp-content/uploads/JMESTN42353068.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs synthesis as well as their toxicological properties. We also highlighted the potential of MOFs as therapeutic agents and nano-MOFs (NMOFs) for biomedical sensing. Water as an alternative media for MOF synthesis showed excellent results in term of particle size, stability and selectivity. Toxicological assessments revealed Fe (III) and MIL-100 as the most promising metal and MOF for medical applications. It was also shown that MOFs are sensitive towards physiological and pathological criteria such as pH, fluorescence and O2. Although many attempts have been made in utilizing MOFs for bio applications, further improvements should be considered before MOFs can become effective therapeutics options.
format Article
author Mostafa, Yousefzadeh Borzehandani
Abdul Malek, Emilia
Abdul Rahman, Mohd Basyaruddin
Mohammad Latif, Muhammad Alif
spellingShingle Mostafa, Yousefzadeh Borzehandani
Abdul Malek, Emilia
Abdul Rahman, Mohd Basyaruddin
Mohammad Latif, Muhammad Alif
Development of metal-organic frameworks for biomedical applications - a review
author_facet Mostafa, Yousefzadeh Borzehandani
Abdul Malek, Emilia
Abdul Rahman, Mohd Basyaruddin
Mohammad Latif, Muhammad Alif
author_sort Mostafa, Yousefzadeh Borzehandani
title Development of metal-organic frameworks for biomedical applications - a review
title_short Development of metal-organic frameworks for biomedical applications - a review
title_full Development of metal-organic frameworks for biomedical applications - a review
title_fullStr Development of metal-organic frameworks for biomedical applications - a review
title_full_unstemmed Development of metal-organic frameworks for biomedical applications - a review
title_sort development of metal-organic frameworks for biomedical applications - a review
publisher Naci kalkan
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf
http://psasir.upm.edu.my/id/eprint/81158/
http://www.jmest.org/wp-content/uploads/JMESTN42353068.pdf
_version_ 1677783011509141504
score 13.211869

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