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Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention

Frequent repositioning is important to prevent pressure ulcer (PU) development, by relieving pressure and recovering damages on skin areas induced by repetitive loading. Although repositioning is the gold standard to prevent PU, there is currently no strategy for determining tissue condition under p...

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Main Authors: Yapp, Jong Heng, Raja Ahmad, Raja Kamil, Mahmud, Rozi, Mohtarrudin, Norhafizah, Mohamad Yusof, Loqman, Abdul Rahim, Ezamin, Ahmad, Siti Anom, Abu Bakar @ Zakaria, Md Zuki
Format: Article
Language:English
Published: Blackwell Publishing 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81130/1/Determining%20weight-bearing%20tissue%20condition%20.pdf
http://psasir.upm.edu.my/id/eprint/81130/
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spelling my.upm.eprints.811302020-09-09T03:03:05Z http://psasir.upm.edu.my/id/eprint/81130/ Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention Yapp, Jong Heng Raja Ahmad, Raja Kamil Mahmud, Rozi Mohtarrudin, Norhafizah Mohamad Yusof, Loqman Abdul Rahim, Ezamin Ahmad, Siti Anom Abu Bakar @ Zakaria, Md Zuki Frequent repositioning is important to prevent pressure ulcer (PU) development, by relieving pressure and recovering damages on skin areas induced by repetitive loading. Although repositioning is the gold standard to prevent PU, there is currently no strategy for determining tissue condition under preventive approaches. In this study, the peak reactive hyperemia (RH) trends and ultrasonographic (US) features are compared with the tissue condition under histopathological examination to determine the potential use of these features in determining the tissue condition noninvasively. Twenty-one male Sprague–Dawley rats (seven per group), with body weight of 385–485 g, were categorized into three groups and subjected to different recovery times, each with three repetitive loading cycles at skin tissues above of right trochanter area. The first, second, and third groups were subjected to short (3 minutes), moderate (10 minutes), and prolonged (40 minutes) recovery, respectively, while applying fixed loading time and pressure (10 minutes and 50 mmHg, respectively), to provide different degree of recovery and tissue conditions (tissue damage and tissue recovery). Peak RH was measured in the three cycles to determine RH trend (increasing, decreasing, and inconsistent). All rat tissues were evaluated using ultrasound at pre- and post-experiment and rated by two raters to categorize the severity of tissue changes (no, mild, moderate, and severe). The tissue condition was also evaluated using histopathological examination to distinguish between normal and abnormal tissues. Most of the samples with increasing RH trend is related to abnormal tissue (71%); while inconsistent RH trends is more related to normal tissue (82%). There is no relationship between the tissue conditions evaluated under ultrasonographic and histopathological examination. Peak RH trend over repetitive loading may serve as a new feature for determining the tissue condition that leading to pressure ulcer. Blackwell Publishing 2019-01-22 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81130/1/Determining%20weight-bearing%20tissue%20condition%20.pdf Yapp, Jong Heng and Raja Ahmad, Raja Kamil and Mahmud, Rozi and Mohtarrudin, Norhafizah and Mohamad Yusof, Loqman and Abdul Rahim, Ezamin and Ahmad, Siti Anom and Abu Bakar @ Zakaria, Md Zuki (2019) Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention. Wound Repair and Regenaration, 27 (3). pp. 225-234. ISSN 1067-1927 10.1111/wrr.12698
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Frequent repositioning is important to prevent pressure ulcer (PU) development, by relieving pressure and recovering damages on skin areas induced by repetitive loading. Although repositioning is the gold standard to prevent PU, there is currently no strategy for determining tissue condition under preventive approaches. In this study, the peak reactive hyperemia (RH) trends and ultrasonographic (US) features are compared with the tissue condition under histopathological examination to determine the potential use of these features in determining the tissue condition noninvasively. Twenty-one male Sprague–Dawley rats (seven per group), with body weight of 385–485 g, were categorized into three groups and subjected to different recovery times, each with three repetitive loading cycles at skin tissues above of right trochanter area. The first, second, and third groups were subjected to short (3 minutes), moderate (10 minutes), and prolonged (40 minutes) recovery, respectively, while applying fixed loading time and pressure (10 minutes and 50 mmHg, respectively), to provide different degree of recovery and tissue conditions (tissue damage and tissue recovery). Peak RH was measured in the three cycles to determine RH trend (increasing, decreasing, and inconsistent). All rat tissues were evaluated using ultrasound at pre- and post-experiment and rated by two raters to categorize the severity of tissue changes (no, mild, moderate, and severe). The tissue condition was also evaluated using histopathological examination to distinguish between normal and abnormal tissues. Most of the samples with increasing RH trend is related to abnormal tissue (71%); while inconsistent RH trends is more related to normal tissue (82%). There is no relationship between the tissue conditions evaluated under ultrasonographic and histopathological examination. Peak RH trend over repetitive loading may serve as a new feature for determining the tissue condition that leading to pressure ulcer.
format Article
author Yapp, Jong Heng
Raja Ahmad, Raja Kamil
Mahmud, Rozi
Mohtarrudin, Norhafizah
Mohamad Yusof, Loqman
Abdul Rahim, Ezamin
Ahmad, Siti Anom
Abu Bakar @ Zakaria, Md Zuki
spellingShingle Yapp, Jong Heng
Raja Ahmad, Raja Kamil
Mahmud, Rozi
Mohtarrudin, Norhafizah
Mohamad Yusof, Loqman
Abdul Rahim, Ezamin
Ahmad, Siti Anom
Abu Bakar @ Zakaria, Md Zuki
Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
author_facet Yapp, Jong Heng
Raja Ahmad, Raja Kamil
Mahmud, Rozi
Mohtarrudin, Norhafizah
Mohamad Yusof, Loqman
Abdul Rahim, Ezamin
Ahmad, Siti Anom
Abu Bakar @ Zakaria, Md Zuki
author_sort Yapp, Jong Heng
title Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
title_short Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
title_full Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
title_fullStr Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
title_full_unstemmed Determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
title_sort determining weight-bearing tissue condition using peak reactive hyperemia response trend and ultrasonographic features: implications for pressure ulcer prevention
publisher Blackwell Publishing
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81130/1/Determining%20weight-bearing%20tissue%20condition%20.pdf
http://psasir.upm.edu.my/id/eprint/81130/
_version_ 1677783008217661440
score 13.211869

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